Tomoatsu Tsuji

Rapid bedside assessment of serum caffeine concentrations using an immunochromatographic screening kit: evaluation of analytical and diagnostic performance in acute caffeine poisoning

Rie Yamamoto, Takeshi Saito, Tomoatsu Tsuji, Seiji Morita

Severe caffeine poisoning can be life-threatening, and rapid identification of toxic or potentially lethal serum caffeine concentrations may provide additional information. However, rapid quantitative analysis using advanced techniques is often unavailable in emergency settings. The Multi-Drug Rapid Test Cassette (CAF10000 + CAF50000), …

Rapid bedside assessment of serum caffeine concentrations using an immunochromatographic screening kit: evaluation of analytical and diagnostic performance in acute caffeine poisoning

Rie Yamamoto, Takeshi Saito, Tomoatsu Tsuji, Seiji Morita

INTRODUCTION: Severe caffeine poisoning can be life-threatening, and rapid identification of toxic or potentially lethal serum caffeine concentrations may provide additional information. However, rapid quantitative analysis using advanced techniques is often unavailable in emergency settings. The Multi-Drug Rapid Test Cassette (CAF10000 + …

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Rapid bedside assessment of serum caffeine concentrations using an immunochromatographic screening kit: evaluation of analytical and diagnostic performance in acute caffeine poisoning

Rie Yamamoto, Takeshi Saito, Tomoatsu Tsuji, Seiji Morita

Severe caffeine poisoning can be life-threatening, and rapid identification of toxic or potentially lethal serum caffeine concentrations may provide additional information. However, rapid quantitative analysis using advanced techniques is often unavailable in emergency settings. The Multi-Drug Rapid Test Cassette (CAF10000 + CAF50000), …

Evaluation of immunochromatography-based urine drug screening and blood drug concentrations in suspected acute poisoning: insights into negative urine drug screening results

Rie Yamamoto, Yukari Maki, Yuri Iketani, Tomoatsu Tsuji et autres

BACKGROUND: Immunochromatography-based urine drug screening (UDS) can have false-positive or false-negative results; thus, interpretation of results requires careful evaluation. A UDS-negative result simply indicates that target drugs were not detected in urine and does not rule out acute poisoning. This study aimed …

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A Case of Acute Intoxication from Sublingually Administering a Liquid Inhalation Product Containing a Marijuana Analogue.

Seiji Morita, Tomoatsu Tsuji, Wataru Noguchi, Y Maki et autres

A 20-year-old man was brought to the emergency room with chief complaints of dysarthria and vomiting after placing several drops of an inhalation liquid containing hexahydrocannabiphorol (HHCP) under his tongue. During ambulance transport, the patient had a post-vomiting convulsion that lasted approximately …

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Diphenyl-tetrazol-propanamide Derivatives Act as Dual-Specific Antagonists of Platelet CLEC-2 and Glycoprotein VI

Nobuo Watanabe, Yoshiko Shinozaki, Sanae Ogiwara, Riko Miyagasako et autres

BACKGROUND: Platelet C-type lectin-like receptor 2 (CLEC-2) induces platelet activation and aggregation after clustering by its ligand podoplanin (PDPN). PDPN, which is not normally expressed in cells in contact with blood flow, is induced in inflammatory immune cells and some malignant tumor …

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Screening and identification of azacyclonol and fexofenadine in human urine using LC–MS/MS

Takeshi Saito, Akira Namera, Rie Yamamoto, Tomoatsu Tsuji et autres

Abstract Azacyclonol metabolized from fexofenadine and pipradrol are structural isomers and are important biomarkers to determine fexofenadine or pipradrol intake. Detecting these two analytes by liquid chromatography–mass spectrometry (LC–MS) allows for their differentiation from structurally similar compounds. This study aimed to confirm …

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Analysis of Grade Classification for Prehospital Injury Severity Scores Applied in Shonan-area Medical Control Council.

Shinjiro Wakai, Takeshi Yamagiwa, Tomoatsu Tsuji, Seiji Morita et autres

OBJECTIVE: To clarify the usefulness of grade classification for injury severity scores applied in Shonan-area Medical Control Council. METHODS: The participants included 11,668 injury cases that occurred in this jurisdiction from April to September 2016. Multivariate analysis was performed using "severity at …

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Comparison of serum and whole blood concentrations in quetiapine overdose cases

Takeshi Saito, Tomoatsu Tsuji, Akira Namera, Seiji Morita et autres

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救急搬送受入れ不可の危険因子の分析(Risk factors for nonacceptance of referrals from paramedics who request emergency transportation: an analysis of emergency transport data from the Kanagawa Prefecture)

Shinjiro Wakai, 梅鉢 梨真子, 平良 隆行, Tomoatsu Tsuji et autres

要旨 【目的】医療機関が消防機関からの救急患者受入れ照会を受諾できないこと（以下「受入れ不可」）の危険因子（とくに患者背景因子と照会先医療機関属性）を明らかにする。【対象】平成25，26年度神奈川県救急搬送実態調査のデータを用いた。「受入れ不可」を目的変数，「年齢」「性別」「平休日」「覚知時間帯」「傷病程度」「内外因」「背景因子」「病床数」を説明変数とし多変量解析を行った。さらに「救命救急センター指定」「一般/精神科病床の有無」で5群に分けて解析した。【結果】全体の受入れ不可率は20.6%であり（全照会数16,722回），「背景因子」のうち「精神疾患」「自殺企図」「薬物」「飲酒」「認知症」「複数科目にまたがるもの」が有意な独立危険因子であった。｢救命救急センター（一般/精神科病床併設）｣の受入れ不可率は10.0%で「背景因子」の影響はなかった。｢非救命救急センター（一般/精神科病床併設）｣の受入れ不可率は19.8%で，「精神疾患」のみが有意な独立危険因子であった。それに対し｢非救命救急センター（一般病床のみ）｣の受入れ不可率は23.7%で，より多くの「背景因子」（「精神疾患」「自殺企図」「薬物」「飲酒」「認知症」「複数科目にまたがるもの」）が有意な独立危険因子であった。【結語】救命救急センターまたは一般/精神科病床併設の医療機関では，患者背景因子の「受入れ不可」に対する影響は少ない。

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Podoplanin is indispensable for cell motility and platelet-induced epithelial-to-mesenchymal transition-related gene expression in esophagus squamous carcinoma TE11A cells

Nobuo Watanabe, Masako Kidokoro, Makiko Rai Tanaka, Shigeaki Inoue et autres

BACKGROUND: The transmembrane glycoprotein podoplanin (PDPN) is upregulated in some tumors and has gained attention as a malignant tumor biomarker. PDPN molecules have platelet aggregation-stimulating domains and, are therefore, suggested to play a role in tumor-induced platelet activation, which in turn triggers …

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Usefulness of next-generation DNA sequencing for the diagnosis of urinary tract infection

Toru Ishihara, Nobuo Watanabe, Shigeaki Inoue, Hiromichi Aoki et autres

Acute urinary tract infection (UTI) is a highly common clinical condition. Although bacterial culture is the gold standard diagnostic test, false negative results may be possible, leading to the pathogen being unidentified. In recent years, bacterial DNA sequencing analysis has garnered much …

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