Lili Zhu

Network analysis of spousal support and fear of childbirth in pregnant women of advanced maternal age

Lili Zhu, Fandi Yin, Jing Li, Xue Cheng et autres

Background: Fear of childbirth is an important perinatal mental health concern, particularly among women of advanced maternal age. However, the specific interrelations between spousal support and fear of childbirth remain unclear. Methods: This cross-sectional study recruited 279 pregnant women of advanced maternal …

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A longitudinal qualitative study on the experiences and needs of women with gestational diabetes regarding blood glucose management using a journey map

Qiong Gao, Yuxia Yang, Lili Zhu, Cimei Li et autres

Introduction: Gestational diabetes mellitus (GDM) is a common pregnancy-related metabolic disorder that increases risks of adverse maternal and fetal outcomes, as well as long-term type 2 diabetes. Effective glycemic management requires addressing women's dynamic experiences and needs across pregnancy and the postpartum …

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EP300 confers protection against acute pancreatitis via acetylating HSF1 and promoting PRKN-mediated mitophagy in pancreatic acinar cells

Lili Zhu, Zehong Qi, Yuhang Fan, S N Tan et autres

BACKGROUND: Acute pancreatitis (AP) is a severe inflammatory disorder characterized by pancreatic self-digestion, often progressing to systemic inflammation. Despite advances in understanding its pathogenesis, effective therapeutic strategies remain limited. Heat shock factor 1 (HSF1), a critical transcription factor that maintains cellular homeostasis …

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Designing an oxidase toolbox for site-directed oxidation of taxanes

Ming‐Yuan Lai, Yu Wei Weng, Jian Wei, Xinyi Lu et autres

Paclitaxel is one of the most prominent drugs for cancer therapy, and its synthesis has long been pursued by scientific community. Although the biosynthetic pathway has been gradually unraveled, its synthetic efficiency remains severely constrained by the low activity and low product …

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Integrated miRNAome, transcriptome, and degradome analyses reveal the role of miRNA–mRNA modules in the biosynthesis of oridonin in Isodon rubescens

Lili Zhu, Xiaoxiao Zhang, Hui Guo, Zihan Xu et autres

Introduction Isodon rubescens contains many bioactive diterpenoids, especially oridonin, which are used both as medicines and drinks. However, the structure and content of the diterpenoids in I. rubescens vary greatly in response to different ecological environments. MicroRNAs (miRNAs) play a pivotal role …

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Inhibiting RhoA Activation via GDP-state Stabilization to Relieve Heart Failure

Mengzhu Xue, Yingquan Liang, Zhen Yuan, Xiangning Liu et autres

SUMMARY High rates of heart failure (HF) morbidity and mortality have made targeting myocardial remodeling—particularly hypertrophy and fibrosis—a key therapeutic focus. RhoA, which regulates cytoskeletal reorganization and cell migration, plays a role in this process. However, RhoA has long been considered “undruggable”, …

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Characterization and differential expression of DNA methyltransferase and demethylase genes in response to abiotic stress in Isodon rubescens

Xiaoxiao Zhang, Lili Zhu, Zihan Xu, Zhimin Wang et autres

BACKGROUND: DNA methylation plays a key role in regulating plant growth and development, secondary metabolism, and environmental adaptability and is affected by DNA methyltransferase (C5-MTase) and demethylase (dMTase). However, the response of C5-MTase and dMTase genes to abiotic stress in Isodon rubescens …

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The role of PSMC4 in non-small cell lung cancer: implications for prognosis, diagnosis, and immune microenvironment modulation

Lili Zhu, Yuanjun Li, Yunfei Xu, Jian Lei

Introduction: Non-small cell lung cancer (NSCLC) remains a principal cause of cancer-related mortality. The discovery of novel biomarkers is pivotal for enhancing early diagnosis, refining prognostic evaluations, and optimizing targeted therapeutic strategies. Proteasome 26S subunit ATPase 4 (PSMC4), a proteasome subunit essential …

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Characterization and differential expression of DNA methyltransferase and demethylase genes in response to abiotic stress in Isodon rubescens

Xiaoxiao Zhang, Lili Zhu, Zihan Xu, Zhimin Wang et autres

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RFX5 promotes the growth, motility, and inhibits apoptosis of gastric adenocarcinoma cells through the SIRT1/AMPK axis

Lili Zhu, Le Qi

Gastric cancer is among the most common gastrointestinal malignancies with high morbidity and mortality rates, highlighting the need to further elucidate its pathogenesis and identify effective therapeutic targets. The regulatory factor X (RFX) gene family encodes transcription factors implicated in the development …

Innovative gene delivery systems for retinal disease therapy

Hongguang Wu, Ling Dong, Shibo Jin, Yong-wang Zhao et autres

The human retina, a complex and highly specialized structure, includes multiple cell types that work synergistically to generate and transmit visual signals. However, genetic predisposition or age-related degeneration can lead to retinal damage that severely impairs vision or causes blindness. Treatment options …

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Regulated cell death in acute myocardial infarction: Molecular mechanisms and therapeutic implications

Lili Zhu, Yiyang Liu, Kangkai Wang, N. Y. Wang

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