Da‐Yong Cao

Prognostic impact of neoadjuvant therapy vs upfront surgery in patients with huge hepatocellular carcinoma undergoing curative resection

Meng-Ran Lang, Ru-Yu Han, Feng-Yi Zhu, Zhi-Hao Wang et autres

Innovative rapid pathological assessment technology for hepatocellular carcinoma following comprehensive treatment guided by indocyanine green fluorescence imaging

Changcheng Tao, Huiru Yang, Nan Hu, Bo Zheng et autres

BACKGROUND: Traditional pathological techniques for diagnosing liver cancer are limited by the need for examination of multiple points. Preoperative treatment can complicate the evaluation by causing tumor necrosis. The evolving treatment landscape requires precise, integrated, and comprehensive management to address the limitations, …

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Prolonged recurrence-free survival by autologous rectronectin-activated killer (RAK) cells in resected high-risk hepatocellular carcinoma: an experimental single-arm phase II trial (pilot study)

Yiran Wang, Jing Xu, Luyao Zhang, Jinlian Tong et autres

BACKGROUND: Hepatocellular carcinoma (HCC) is prone to recurrence following hepatectomy, posing significant clinical challenges. Our previous research suggested that adoptive T-cell therapy could improve the impaired liver microenvironment. This study aimed to evaluate the efficacy and safety of adjuvant RetroNectin-Activated Killer (RAK) …

cn (code pays fourni par la source)

Comparison of treatment models for single primary advanced gallbladder cancer

Rongxuan Li, Bingchen Wang, Bolun Ai, Da‐Yong Cao et autres

Purpose: Treatment for advanced gallbladder cancer (GBC) remains controversial, with various recommendations regarding the choice and combination of surgery and adjuvant therapy. The present article is targeting for the exploration of optimal treatment models for advanced GBC. Methods: AJCC (American Joint Committee …

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Comprehensive evaluation of clinical outcomes in hepatic epithelioid hemangioendothelioma subsets: insights from SEER Database and departmental cohort analysis

Bingchen Wang, Rongxuan Li, Bolun Ai, Feng Ye et autres

Background: Epithelioid hemangioendothelioma (EHE), is an uncommon, intermediate-grade malignant vascular tumor that can manifest in diverse organs, including the liver, lungs, and bones. Given its unique malignancy profile and rarity, there lacks a consensus on a standardized treatment protocol for EHE, particularly …

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Radiotherapy with Targeted Therapy or Immune Checkpoint Inhibitors for Hepatocellular Carcinoma with Hepatic Vein and/or Inferior Vena Cava Tumor Thrombi

Zhuoran Li, Yirui Zhai, Fan Wu, Da‐Yong Cao et autres

Purpose: This study evaluated the clinical outcomes of patients with hepatocellular carcinoma (HCC) with hepatic vein tumor thrombus (HVTT) and/or inferior vena cava tumor thrombus (IVCTT) receiving radiotherapy (RT) combined with systemic therapies. Patients and Methods: Patients with HCC with HVTT and/or …

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An adaptive modelling method based on infill strategy maximum entropy

Honggang Zhang, Ting Wang, Da‐Yong Cao, Xinghua Li

Instead of the real finite element model, the the approximate model can achieve a balance between calculation accuracy and computational cost, and computation efficiency can also be improved. There are two main ways to implement approximate Modelling: (1) Single step Modelling method; …

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P-797 Single-cell analysis sheds light on investigation of epithelial stem/progenitor cells in human endometrial organoid

Jiuru Li, Da‐Yong Cao, Pcn Chiu, C L Lee

Abstract Study question How to find endometrial epithelial stem cell (eeSC) in the human endometrial gland? Summary answer Endometrial organoid culture model combined with omics techniques can be a promising platform for investigating eeSC functions and endometrial gland development. What is known …

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P-796 Single-cell transcriptomics unveils a role for leptin receptor in human endometrial mesenchymal stromal/stem cells

Fang Ye, Da‐Yong Cao, Rachel Chan, C L Lee et autres

Abstract Study question What are the characteristics of leptin receptor (LepR) expressing cells within the endometrial mesenchymal stromal/stem cells (eMSCs) population? Summary answer LepR+ eMSCs display better stem-cell capacities as well as distinctively quiescent properties compared to eMSCs and LepR- eMSCs. What …

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Mannose Binding Lectin (MBL) and MBL Associated Serine Protease-2 (MASP-2) Amplify SARS-CoV-2 Spike Protein Uptake and Epithelial Cell Injury During Cigarette Smoke Exposure

Karina A. Serban, Andrew M. Mikosz, Da‐Yong Cao, N. Egersdorf et autres

RationaleThe clinical syndrome associated with SARS-CoV2, known as COVID-19 is characterized by a spectrum of hypercoagulability and complement-mediated microvascular injury in severe but also in mild COVID-19 disease(1-4). Studies have demonstrated that lectin complement pathway (driven by MBL/MASP2 complex) is responsible for …

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Antigen-specific T cell response from dendritic cell vaccination using side population cell-associated antigens targets hepatocellular carcinoma

Xiao Li, Zhuochao Zhang, Guoying Lin, Yuan-Xing Gao et autres

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Annexin A2 Promotes the Migration and Invasion of Human Hepatocellular Carcinoma Cells In Vitro by Regulating the Shedding of CD147-Harboring Microvesicles from Tumor Cells

Wei Zhang, Pu Zhao, Xiu-Li Xu, Lei Cai et autres

It has been reported that Annexin A2 (ANXA2) is up-regulated in hepatocellular carcinoma (HCC), but the roles of ANXA2 in the migration and invasion of HCC cells have not been determined. In this study, we found that ANXA2-specific siRNA (si-ANXA2) significantly inhibited …

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