Mengzhen Li

Arylboron Tetraphenylethylene-Analog AIEgens Enabling Reversible Closed-Shell/Open-Shell Switching

Haoyu Gao, Yan Tang, Pengchao Liu, Mengzhen Li et autres

Achieving the synergistic integration of emission regulation and reversible electronic-state switching in aggregation-induced emission (AIE) systems remains challenging, as it requires balancing restriction of intramolecular motion (RIM) with spin delocalization. Here, we construct a class of arylboron-functionalized tetraphenylethylene-analog molecules and systematically elucidate …

cn, hk, fr (code pays fourni par la source)

Tim-3 facilitates dendritic cell ferroptosis and impairs antitumor immunity in steatohepatitis-related HCC

Na Li, Xiaojia Song, Xueqi Peng, Mengzhen Li et autres

Background & Aims Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading cause of hepatocellular carcinoma (HCC) and confers resistance to immunotherapy. However, the underlying mechanisms remain unclear. We aimed to elucidate how the lipid-rich microenvironment of MASLD-HCC drives immune suppression and …

cn (code pays fourni par la source)

GEGAN: gradient-guided evolutionary framework for GAN optimization

Wenwen Jia, Qi Wei Yu, Xijun Liang, Mengzhen Li et autres

cn (code pays fourni par la source)

Side‐Chain Engineering Guides the Design of β‐Sheet Inhibitor to Anchor Protein‐Protein Interaction Interfaces

Limin Zhang, Minxuan Wang, Bo Wang, Jinge Zhao et autres

Abstract Customizing inhibitors for β‐sheet mediated protein‐protein interactions (PPIs) remains a challenge in medicinal chemistry research. Directly separating β‐sheet elements from the PPI interface as inhibitors represents a feasible strategy. Although useful, peptides derived from PPIs typically lose their natural secondary structure, …

cn, sg (code pays fourni par la source)

Side‐Chain Engineering Guides the Design of β‐Sheet Inhibitor to Anchor Protein‐Protein Interaction Interfaces

Limin Zhang, Minxuan Wang, Bo Wang, Jinge Zhao et autres

Customizing inhibitors for β-sheet mediated protein-protein interactions (PPIs) remains a challenge in medicinal chemistry research. Directly separating β-sheet elements from the PPI interface as inhibitors represents a feasible strategy. Although useful, peptides derived from PPIs typically lose their natural secondary structure, resulting …

cn, sg (code pays fourni par la source)

IL1R2 Marks and Sorts a Spermatogonial Stem Cell Population Critical for Restoring Spermatogenesis Upon Interruption in Mammals

Pengyu Li, Z. Zhang, Zihan Xie, Chen Jin et autres

ABSTRACT Self‐renewal and differentiation of spermatogonial stem cells (SSCs) are critical for sustaining spermatogenesis in adult mammals. However, SSCs are highly heterogeneous, comprising a complex array of subpopulations whose identities and dynamic transitions remain greatly underappreciated. Through in silico analysis, we identified …

cn (code pays fourni par la source)

Global Well-posedness of Hamilton-Jacobi Equations for Linear-Quadratic Mean Field Control Problems

Mengzhen Li, Chenchen Mou, Zhenhua Wu, Chao Zhou

Abstract In this manuscript, we investigate the global well-posedness of the Hamilton-Jacobi equation for linear-quadratic (LQ) mean field control problems with a common noise, along with the corresponding N -particle systems. The mean field control problems considered are not standard LQ mean …

hk, cn (code pays fourni par la source)

A root system architecture regulator modulates OsPIN2 polar localization in rice

Yong Li, Meiyan Ren, Yunrong Wu, Lingling Wang et autres

Ideal root system architecture (RSA) is important for efficient nutrient uptake and high yield in crops. We cloned and characterized a key RSA regulatory gene, GRAVITROPISM LOSS 1 (OsGLS1), in rice (Oryza sativa L.). The gls1 mutant displays an increased root growth …

cn, gb (code pays fourni par la source)

Probiotics and their metabolite spermidine enhance IFN-γ+CD4+ T cell immunity to inhibit hepatitis B virus

Tixiao Wang, Yu‐Chen Fan, Siyu Tan, Zehua Wang et autres

The therapeutic potential of commensal microbes and their metabolites is promising in the functional cure of chronic hepatitis B virus (HBV) infection, which is defined as hepatitis B surface antigen (HBsAg) loss. Here, using both specific-pathogen-free and germ-free mice, we report that …

cn (code pays fourni par la source)

Integrated analysis reveals the immunotoxicity mechanism of BPs on human lymphocytes

Qiujin Zhang, Mengzhen Li, Ping Wang, Xiao Lin et autres

cn, us (code pays fourni par la source)

GEGAN: Generative Adversarial Networks Training Based on Gradient Directed Evolutionary Strategy

Mengzhen Li, Xinmin Pei, Xijun Liang, Qi Huang Yu et autres

Deep generative models play a crucial role across various domains, with Generative Adversarial Networks (GANs) leading the advancements in deep generative techniques. However, GANs face challenges like unstable training and mode collapse, impacting image generation quality. In this paper, we introduce an …

cn (code pays fourni par la source)

NGDE: A Niching-Based Gradient-Directed Evolution Algorithm for Nonconvex Optimization

Qi Wei Yu, Xijun Liang, Mengzhen Li, Ling Jian

Nonconvex optimization issues are prevalent in machine learning and data science. While gradient-based optimization algorithms can rapidly converge and are dimension-independent, they may, unfortunately, fall into local optimal solutions or saddle points. In contrast, evolutionary algorithms (EAs) gradually adapt the population of …

cn (code pays fourni par la source)