Yifan Hu

Epididymal macrophage senescence contributes to sperm motility decrease upon environmental stress

Xin-Run Wang, Hao Li, Yong-Wei Xiong, Zhi Yuan et autres

Environmental stressors–induced male infertility has become a major public health issue. Sperm motility is the key to conception. However, the immunological mechanism for environmental stress–induced sperm motility reduction remains unknown. Our experiments find that three classical environmental stressors, including lead, cadmium, and …

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Water consumption contributes to maternal PFAS exposure: From source to metabolic perturbations

Wei Chang, Yong-Wei Xiong, Jian Sun, Lanlan Wu et autres

Per- and polyfluoroalkyl substances (PFAS) are widespread persistent pollutants and pose a risk to human health. However, the transfer efficiencies (TEs) of PFAS from source water into maternal serum, and its metabolic pathways linking PFAS exposure and human disease are remain unclear. …

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β-defensin 2 enhances antiviral immunity via autophagy regulation during Micropterus salmoides rhabdovirus (MSRV) infection and promotes survival in largemouth bass

Yongfei Zhu, Yifan Hu, Changhong Li, Jiong Chen

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Metal bioaccumulation and lipid response in aquatic ecosystem: Evidence of machine learning from Chaohu Lake, China

Qi Lü, Zhiyong Yuan, Wei Chang, Song Xu et autres

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A Photothermal Agent with Multiple Hot Shock Proteins Inhibition for Enhanced Tumor Photothermal Therapy and Intrinsic Apoptosis

Jiexuan Zuo, Zhiyuan Ma, Zehou Su, Yifan Hu et autres

Abstract Photothermal therapy (PTT) represents a conventional phototherapeutic strategy for tumors; however, the high‐temperature ablation of tumors by photothermal agents inevitably induces a cascade of heat shock responses (HSRs) in tumor cells. HSRs increase tumor thermal resistance by upregulating the expression of …

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Association of β-blockers with methotrexate efficacy in psoriasis patients with hypertension: A retrospective cohort study

Dawei Huang, Rui Ma, Ssw Lin, Jiangluyi Cai et autres

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Early inadequate response to biological agents portends treatment failure at 6 months in patients with psoriasis: A multicenter, prospective cohort study

Yuxiong Jiang, Lingling Yao, Xiaoyuan Zhong, Dawei Huang et autres

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Metal Bioaccumulation and Lipid Response in Aquatic Ecosystem: Evidence of Machine Learning from Chaohu Lake, China

Qi Lü, Zhiyong Yuan, Wei Chang, Song Xu et autres

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Prediction of Market Share of Different Vehicle Powertrains on Interprovincial Highways amid the Development of Urban Agglomerations

Jianhong Ye, Yifei Qin, Guanpei Luo, Yifan Hu et autres

In the coordinated development of urban agglomerations in China, inter-city connections within urban agglomerations have been gradually strengthened, with more interprovincial highways built. Given the complex geological conditions, interprovincial highways often require tunnels. The construction of tunnel ventilation facilities needs to take …

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Comprehensive Analysis of Proteins and Their Phosphorylation in Milk-derived Exosomes From Different Species

Chang‐Mei Liu, Yifan Hu, CHEN Wen-Yan, LIU Dan et autres

ObjectiveExosomes are microvesicles which could be secreted by all cell types with diameters between 30 and 150 nm. It was widely distributed in body fluids including blood, urine, and breast milk. Exosomes are considered as potential biomarkers and drug carriers by reason …

Spesolimab rapidly treats generalized pustular psoriasis and improves the skin immune microenvironment in Chinese patients

Jiajing Lu, Qian Yu, Dawei Huang, Yifan Hu et autres

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Data-Driven Framework for Generating Travelers with Demographic-Activity-Travel Information

Jianhong Ye, Yifan Hu, Lei Gao

Transportation demand models and traffic simulations, particularly in the realm of innovative activity-based models, necessitate comprehensive demographic-activity-travel data. Although cell phone data holds the potential to provide detailed insights into activity-travel patterns, transportation planners often resort to aggregate data, constrained by limited …

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