Chiara Sartori

One-step diagnosis and treatment of an atypical large granular cell tumor of the colon

Andrea Michielan, Federico Iacopini, Chiara Sartori, Chiara Trentin et autres

A subepithelial lesion in the ascending colon was incidentally detected on computed tomography scan of the abdomen performed to rule out other diagnoses in a 50-year-old woman with recurrent deep vein thrombosis and heterozygosity for the Leiden mutation of the factor V …

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Complete pathological response to pembrolizumab in pretreated pancreatic acinar cell carcinoma

Valeria Merz, Francesca Maines, Stefano Marcucci, Chiara Sartori et autres

BACKGROUND: Therapeutic approach used for pancreatic ductal adenocarcinoma is usually translated also for the rarer acinar counterpart, which shows a different mutational landscape nevertheless. While dMMR/MSI-H status is rare in the ductal histotype, it appears to be more prevalent in pancreatic acinar …

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Increased genomic instability and reshaping of tissue microenvironment underlie oncogenic properties of Arid1a mutations

A. Dambrosio, Davide Bressan, Elisa Ferracci, Francesco Giuseppe Carbone et autres

Oncogenic mutations accumulating in many chromatin-associated proteins have been identified in different tumor types. With a mutation rate from 10 to 57%, ARID1A has been widely considered a tumor suppressor gene. However, whether this role is mainly due to its transcriptional-related activities …

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Mixed Invasive Apocrine Papillary/Micropapillary Carcinoma of the Breast: Another Brick in the Triple-Negative Wall

Luca Cima, Nicola Mirabassi, Chiara Sartori, Francesco Giuseppe Carbone et autres

Pure invasive papillary carcinoma (IPC) is a rare subtype of breast carcinoma with good prognosis compared with classical invasive breast carcinoma (IBC) of no special type. The majority of IPC are estrogen receptor and progesterone receptor (ER/PR) positive and HER2 negative (luminal …

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Mammalian embryo comparison identifies novel pluripotency genes associated with the naïve or primed state

Andreia S. Bernardo, Alice Jouneau, Hendrik Marks, Philip Kensche et autres

During early mammalian development transient pools of pluripotent cells emerge that can be immortalised upon stem cell derivation. The pluripotent state, “naïve” or “primed”, depends on the embryonic stage and derivation conditions used. Here we analyse the temporal gene expression patterns of …

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Generation of ovine induced pluripotent stem cells

Chiara Sartori

Embryonic stem cells (ESCs) are pluripotent cells derived from the early embryo and are able to differentiate into cells belonging to the three germ layers. They are a valuable tool in research and for clinical use, but their applications are limited by …

Reprogramming Pig Fetal Fibroblasts Reveals a Functional LIF Signaling Pathway

Alison J. Thomson, Hadrien Pierart, Stephen Meek, Alexandra Bogerman et autres

Distinct signaling pathways are reported to maintain pluripotency in embryo-derived stem cells. Mouse embryonic stem cells (ESCs) respond to leukemia inhibitory factor (LIF) and bone morphogenetic protein (BMP)-mediated activity, whereas human ESCs depend upon Fibroblast growth factor (FGF) and activin signaling. In …

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Ovine-Induced Pluripotent Stem Cells Can Contribute to Chimeric Lambs

Chiara Sartori, Alex I. DiDomenico, Alison J. Thomson, Elspeth Milne et autres

Pluripotential stem cells from livestock offer an exciting prospect for the biotechnology industry. Applying strategies established for the derivation of murine induced pluripotential stem cells (iPSCs), we have isolated ovine iPSCs that can give rise to cells characteristic of all three germ …

it, gb (code pays fourni par la source)

[Vegetative nervous system and extrapleural pulmonary collapse therapy].

Chiara Sartori