Lijun Yuan

Truncated Gpr114-based ultrasound-hypersensitive gene circuit for controlled expression of therapeutics

Pengying Wu, Yubo Lai, Yang Liu, Zihang Li et autres

Sonogenetic holds great potential for modulating cellular functions and behaviors. However, developing hypersensitive ultrasound (US)-responsive receptors remains a substantial challenge. Here, we combine AlphaFold3 prediction with molecular dynamics simulations to identify a hypersensitive Gpr114 protein variant (T-Gpr114) that responds to short-pulse US …

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Wearable ultrasound: Design, development, and application in precision medicine

Hanxi Dong, Xiao Liang, Xin Liu, 邢长洋 et autres

Wearable ultrasound technology has recently emerged as a promising tool in medicine that combines advances in materials science, electronic engineering, and medical imaging to provide innovative solutions for clinical diagnosis and therapy. By miniaturizing ultrasound devices and incorporating flexibility and intelligence, this …

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Minute-level alkylation of heteroarenes via a photo-Fenton mechanism in continuous flow

Xiaobin Ge, Lijun Yuan, Qiqi Sun, Ting Jun Lin et autres

A photo-Fenton flow protocol that converts inexpensive H 2 O 2 into ˙OH radical using a ferrocenyl diphenylphosphine oxide photocatalyst was developed for downstream hydrogen atom abstraction, enabling the minute-level alkylation of heterocycles.

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MSTA-YOLOv11: an improved detection model for maize pests and diseases under complex scenes

Lijun Yuan, Fang Wang

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Occupational polycyclic aromatic hydrocarbons (PAHs) exposure and aging trajectory : Epidemiologic evidence from a cohort of Chinese coke oven workers (2019-2023)

Yidong Wang, Shasha Geng, Wenyu Wang, Lijun Yuan et autres

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Correction: Integrative speckle-tracking echocardiography for the early detection and prediction of cancer therapy–related cardiac dysfunction

Shuo Qiu, Yuxin Zhang, Ying Hou, Songhao Chen et autres

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A Revised Grading Scheme for Secondary Tricuspid Valve Regurgitation

Xi Zhang, Yuxin Zhang, Han Li, Ying Hou et autres

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Ultrasound spatiotemporally enables prolonged therapeutic mRNA translation in engineered bacteria for enhanced cancer immunotherapy

Zhaoyou Liu, Lantian Wang, Jiahui An, Mengying Wei et autres

Rationale: Engineered bacteria have recently emerged as a novel and promising strategy for cancer immunotherapy.Nonetheless, precise spatiotemporal regulation of therapeutic gene expression within these bacteria is essential to optimize therapeutic efficacy while minimizing adverse effects.This study aims to develop a system for …

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Integrative speckle-tracking echocardiography for the early detection and prediction of cancer therapy–related cardiac dysfunction

Shuo Qiu, Yuxin Zhang, Ying Hou, Songhao Chen et autres

BACKGROUND: The cancer therapy–related cardiac dysfunction (CTRCD) induced by anthracycline could involve the whole heart. However, the overall changes of strain parameters, including the atrial and right heart strains, myocardial work, along with the established left ventricular global longitudinal strain (GLS), during …

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Therapeutic Applications of Nanodroplets in Ultrasound: In Vitro and in Vivo Perspectives

Lantian Wang, Zhaoyou Liu, Yubo Lai, Wenxin Tao et autres

Once the vapor pressure of a volatile liquid exceeds the ambient air pressure, the liquid droplets vaporize. This principle has led to the development of a type of nanodroplets that can transform into microbubbles upon ultrasound exposure. The unique phase-transition properties of …

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A narrative review: Ultrasound-Assisted drug delivery: Improving treatments via multiple mechanisms

Wenxin Tao, Yubo Lai, Xueying Zhou, Pengying Wu et autres

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Inhibitory mechanism of chlorogenic acid-grafted chitosan against Pseudomonas fluorescens: Interruption of iron uptake

Xin Yang, Lijun Yuan, Xiaohong Sun, Weiqing Lan

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