Yu-Fan Chang

Pathologic Genetic Mutations May Correlate with Poor Visual Outcome in Patients with Hydroxychloroquine Retinopathy

Hsun-I Chiu, Hui‐Chen Cheng, Chih-Chiau Wu, Shih‐Jen Chen et autres

INTRODUCTION: To evaluate the progression rate and identify potential genetic risk factors for poor visual outcome in chloroquine/hydroxychloroquine (CQ/HCQ) retinopathy. METHODS: Ocular variables, including best-corrected visual acuity (BCVA), hypoautofluorescent area in fundus autofluorescence (FAF) and others were analyzed in patients with a …

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Centrifugal electrospun bimetallic PtFe nanowires as electrocatalyst for oxygen reduction reaction in polymer electrolyte membrane fuel cells

Wei‐Hsin Chen, Yu-Fan Chang, Min‐Hsing Chang

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Exome sequencing and genome-wide association analyses unveils the genetic predisposition in hydroxychloroquine retinopathy

Hsun-I Chiu, Hui‐Chen Cheng, Chih-Chiau Wu, Shih‐Jen Chen et autres

Abstract Objectives To unveil the candidate susceptibility genes in chloroquine/hydroxychloroquine (CQ/HCQ) retinopathy using whole exome sequencing (WES) and genome-wide association study (GWAS). Methods Patients with a diagnosis of CQ/HCQ retinopathy based on the comprehensive demographic and ocular examination were included. The peripheral …

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Exome sequencing and genome-wide association analyses unveils the genetic predisposition in hydroxychloroquine retinopathy

An-Guor Wang, Hsun-I Chiu, Hui‐Chen Cheng, Chih-Chiau Wu et autres

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Data from Statins Increase p21 through Inhibition of Histone Deacetylase Activity and Release of Promoter-Associated HDAC1/2

Yi‐Chu Lin, Jung‐Hsin Lin, Chia‐Wei Chou, Yu-Fan Chang et autres

Abstract Statins are 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors broadly used for the control of hypercholesterolemia. Recently, they are reported to have beneficial effects on certain cancers. In this study, we show that statins inhibited the histone deacetylase (HDAC) activity and increased the accumulation of …

Supplementary Figures 1-2 from Statins Increase p21 through Inhibition of Histone Deacetylase Activity and Release of Promoter-Associated HDAC1/2

Yi‐Chu Lin, Jung‐Hsin Lin, Chia‐Wei Chou, Yu-Fan Chang et autres

Supplementary Figures 1-2 from Statins Increase p21 through Inhibition of Histone Deacetylase Activity and Release of Promoter-Associated HDAC1/2

Supplementary Figures 1-2 from Statins Increase p21 through Inhibition of Histone Deacetylase Activity and Release of Promoter-Associated HDAC1/2

Yi‐Chu Lin, Jung‐Hsin Lin, Chia‐Wei Chou, Yu-Fan Chang et autres

Supplementary Figures 1-2 from Statins Increase p21 through Inhibition of Histone Deacetylase Activity and Release of Promoter-Associated HDAC1/2

Data from Statins Increase p21 through Inhibition of Histone Deacetylase Activity and Release of Promoter-Associated HDAC1/2

Yi‐Chu Lin, Jung‐Hsin Lin, Chia‐Wei Chou, Yu-Fan Chang et autres

Abstract Statins are 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors broadly used for the control of hypercholesterolemia. Recently, they are reported to have beneficial effects on certain cancers. In this study, we show that statins inhibited the histone deacetylase (HDAC) activity and increased the accumulation of …

Anti-apoptotic and autophagic effect: Using conditioned medium from human bone marrow mesenchymal stem cells to treat human trabecular meshwork cells

Yu-Fan Chang, Yung‐Hsin Cheng, Yu‐Chieh Ko, Shih‐Hwa Chiou et autres

Introduction: Glaucoma is a vision-threatening disease associated with accelerated aging of trabecular meshwork (TM) which results in elevated intraocular pressure (IOP). Increased oxidative stress in TM plays an important role in cellular molecular damage which leads to senescence. Autophagy is an intracellular …

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Fabrication of platinum-cobalt nanowires by centrifugal electrospinning as oxygen reduction catalyst for PEMFC

Yu-Fan Chang, Chenyu Wu, Min‐Hsing Chang

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Bleb-related infection after primary trabeculectomy: medical chart reviews from 1993 to 2021

Hsin‐Yu Yang, Sheng-Chu Chi, Yu‐Chieh Ko, Mei‐Ju Chen et autres

BACKGROUND: To investigate the incidence of and risk factors for bleb-related infection (BRI) in patients who underwent mitomycin C-augmented primary trabeculectomy. METHODS: We reviewed the medical charts of consecutive patients who had received primary trabeculectomy in Taipei Veterans General Hospital. We recorded …

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Risks of posterior segment ocular ischaemic events in patients with systemic lupus erythematosus: a population-based cohort study in Taiwan

Yi‐Ran Chiou, Yu‐Sheng Chang, Chin‐Fang Su, Tzu-Hao Li et autres

BACKGROUD/AIM: Ocular involvement in systemic lupus erythematosus (SLE) is often primarily recognised by ophthalmologists rather than internists. This study aims to investigate the incidence and risk factors for the occurrence of posterior ocular ischaemic events (OIE), including retinal vein occlusion (RVO), retinal …

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