Qingtian Li

Deletion of Megalin in Kidney Tubular Epithelium Upregulates Transforming Growth Factor (TGF)β1 Signaling, Aggravates Ischemia-Reperfusion Kidney Injury, and Accelerates Progression to CKD

Qingtian Li, David Sheikh‐Hamad

Background: Ischemic acute kidney injury (AKI) may accelerate the progression to end-stage kidney disease (ESKD). We have shown stanniocalcin-1 (STC1) promotes mitochondrial anti-oxidant defenses and confers resistance to ischemia/reperfusion (I/R) kidney injury. We have also shown STC1 is shuttled by megalin to …

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Overexpression of Megalin in Kidney Tubular Epithelium Protects from Ischemia-Reperfusion (I/R) Kidney Injury; Sustained Overexpression of Megalin After I/R Induces Clonal Hematopoiesis

Qingtian Li, David Sheikh‐Hamad

Background: Ischemic AKI may accelerate the progression to end-stage kidney disease (ESKD). We have recently shown megalin shuttles the mitochondrial intracrines STC1, Angiotensin II and TGF-β1 from the cell surface to the mitochondria. Within the mitochondria, megalin associates with STC1 and SIRT3, …

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Interplay between Skeletal Muscle Catabolism and Remodeling of Arteriovenous Fistula by Yes-Associated Protein 1 (YAP1) Signaling

Yongdong Wu, Tae Hoon Lee, Owen H. Cheng, Eric K. Peden et autres

Key Points Atrophied muscle–derived myostatin stimulated mesenchymal stem cell differentiation and adverse arteriovenous (AV) fistula remodeling through yes-associated protein 1 (YAP1) activation. Treatment with myostatin peptibody inhibited muscle wasting and blocked mesenchymal stem cell activation and AV fistula fibrosis. A light-sensitive drug-release …

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Mechanisms of gelofusine protection in an in vitro model of polymyxin B-associated renal injury

Cole S Hudson, Anirban Roy, Qingtian Li, Aniket S. Joshi et autres

Gelofusine is a gelatinous saline solution with the potential to attenuate polymyxin-associated nephrotoxicity. We demonstrated that the mechanisms of gelofusine renal protection involve reducing polymyxin B uptake by proximal tubule cells, limiting subsequent oxidative stress and apoptosis activation. In addition, gelofusine was …

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T‐bet Regulates Ion Channels and Transporters and Induces Apoptosis in Intestinal Epithelial Cells

Lang Chen, Hongwei Yi, Qingtian Li, Tianhao Duan et autres

Abstract T‐bet, encoded by TBX21, is extensively expressed across various immune cell types, and orchestrates critical functions in their development, survival, and physiological activities. However, the role of T‐bet in non‐immune compartments, notably the epithelial cells, remains obscure. Herein, a Tet‐O‐T‐bet transgenic …

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Megalin Facilitates the Regulation of Mitochondrial Function by Extracellular Cues

Qingtian Li, David Sheikh‐Hamad

ABSTRACT Megalin (also known as low density lipoprotein-receptor related protein 2 [LRP2]) is a multi-ligand cell-surface endocytic receptor expressed widely; it is important for the uptake of vitamins, nutrients and hormones. We recently reported the discovery of LRP2/megalin in the mitochondria of …

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Tubular Epithelium-Specific Deletion of Megalin Aggravates Ischemia/Reperfusion Kidney Injury and Accelerates the Progression to CKD

Qingtian Li, Michael W. Holliday, Jenny S. Pan, David Sheikh‐Hamad

Background: Ischemic AKI may accelerate the progression to ESKD. We have shown stanniocalcin-1 (STC1) activates AMPK and promotes mitochondrial antioxidant defenses through upregulation of uncoupling protein 2 and SIRT3. Transgenic overexpression of STC1 confers resistance to ischemia/reperfusion (I/R) kidney injury. We have …

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Stanniocalcin-1 Ameliorates Ischemia-Reperfusion Kidney Injury via Selective Activation of AMPK-a2

Jenny S. Pan, Qingtian Li, David Sheikh‐Hamad

Background: Acute kidney injury (AKI) is common and is associated with increased morbidity, mortality, and development/progression of chronic kidney disease. Currently, therapeutic options remain limited. AMPK activation has been found to protect from AKI. However, there are concerns about off target effects …

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Potential Mechanisms Involved in Chronic Kidney Disease of Unclear Etiology

Michael W. Holliday, Qingtian Li, Edlyn G. Bustamante, Jingbo Niu et autres

Background and objectives The etiology of chronic kidney disease of unclear etiology, also known as Mesoamerican nephropathy, remains unclear. We investigated potential etiologies for Mesoamerican nephropathy in an immigrant dialysis population. Design, setting, participants, & measurements Migrants with Mesoamerican nephropathy kidney failure …

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Downregulation of lncRNA NEAT1 alleviates sepsis-induced acute kidney injury

Yuhua Zhou, Yihui Wang, Qingtian Li, Ke Dong et autres

Sepsis-induced acute kidney injury (AKI) is one of the important causes of increased mortality in sepsis patients. Long non-coding RNA (lncRNA) is believed to play a vital function in the progression of AKI. However, the mechanism of nuclear enriched abundant transcript 1 …

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Downregulation of the endothelial histone demethylase JMJD3 is associated with neointimal hyperplasia of arteriovenous fistulas in kidney failure

Shaozhen Feng, Eric K. Peden, Qunying Guo, Tae Hoon Lee et autres

Jumonji domain-containing protein-3 (JMJD3), a histone H3 lysine 27 (H3K27) demethylase, promotes endothelial regeneration, but its function in neointimal hyperplasia (NIH) of arteriovenous fistulas (AVFs) has not been explored. In this study, we examined the contribution of endothelial JMJD3 to NIH of …

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Interactions between leucines within the signal peptides of megalin and stanniocalcin-1 are crucial for regulation of mitochondrial metabolism

Qingtian Li, Michael W. Holliday, Jenny S. Pan, Tan Li et autres

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