Zhaohui Ni

Impact of diabetes on survival and clinical outcomes in elderly patients receiving peritoneal dialysis

Luyao Xu, Yue Qian, Qianhui Song, Hao Yan et autres

This study investigated the clinical outcomes and mortality risks in elderly peritoneal dialysis (PD) patients with diabetes mellitus (DM). A total of 210 incident PD patients aged 70 years or older (mean age 80.7 ± 5.0 years; 60.5% men) who initiated treatment …

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Functionalized biomimetic nanoplatforms breaching the blood–brain barrier: A targeted therapeutic strategy for cerebral ischemia–reperfusion injury

Yinyan Wang, Binghe Wang, Fengbo Su, Enqi Wu et autres

• Pathogenesis of cerebral ischaemia–reperfusion injury (CIRI): CIRI is caused by local ischaemia, with severe inflammatory responses, oxidative stress, and damage to the blood–brain barrier (BBB) being its key pathological features, leading to neuronal damage and loss of brain tissue function. • …

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Prospective Randomized Controlled 96-week Study to Evaluate the Efficacy and Safety of Tacrolimus and Glucocorticoid as Continuous Induction-Maintenance Treatment for Class III/IV±V Lupus Nephritis

Tak Mao Chan, Yat Hin Desmond Yap, Zhaohui Ni, Yingyos Avihingsanon et autres

Background: Tacrolimus (TAC) and glucocorticoid as continuous induction-maintenance therapy for lupus nephritis (LN) has never been investigated. We conducted a prospective randomized open-label multicenter study to evaluate its efficacy and safety against standard-of-care mycophenolate (MMF) and glucocorticoid dual immunosuppression in Asian patients …

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Inflammation-Driven Differential Response to Intravenous versus Oral Iron Supplementation in Hemodialysis Patients: A post hoc Analysis of the IHOPE Trial

Haijiao Jin, Renhua Lu, Juan Cao, Hua Li et autres

INTRODUCTION: Anemia is common in hemodialysis patients, and iron supplementation is essential for its management. However, the impact of baseline inflammation on the efficacy of oral versus intravenous iron remains unclear. METHODS: This post hoc analysis of the IHOPE trial included 193 …

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Association between sarcopenic obesity and mortality in patients on peritoneal dialysis: a prospective cohort study

Yiwei Shen, Xinyu Su, Zanzhe Yu, Hao Yan et autres

Background Whether sarcopenic obesity had unfavorable effect on survival of peritoneal dialysis (PD) patients is unknown. We aimed to investigate the association between sarcopenic obesity and survival in PD patients. Methods This was a prospective observational study. Eligible PD patients from November …

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Fractal analysis: Left ventricular trabecular complexity cardiac MRI adds independent risks for heart failure with preserved ejection fraction in participants with end-stage renal disease

Tianyi Zhang, Dong‐Aolei An, Hang Zhou, Zhaohui Ni et autres

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Comparison of the Oral Calcimimetics Evocalcet and Cinacalcet in East Asian Patients on Hemodialysis with Secondary Hyperparathyroidism

Zhaohui Ni, Xinling Liang, Chia‐Chao Wu, Kyubok Jin et autres

Introduction Evocalcet is an oral calcimimetic agent with proven efficacy and safety in treating secondary hyperparathyroidism (SHPT) in Japanese patients on dialysis. Methods This randomized, double-blind, intrapatient dose-adjustment, parallel-group, international multicenter study compared the efficacy and safety of evocalcet versus cinacalcet for …

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A Phase I, Multiple-Dose, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Pharmacokinetics, Safety, and Tolerability of Etelcalcetide Administered Intravenously to Chinese Patients With Chronic Kidney Disease Undergoing Hemodialysis

Changying Xing, Jing Chen, Li Zuo, Yi Fang et autres

Purpose This study reports data from the first evaluation of etelcalcetide treatment in Chinese adults with chronic kidney disease and secondary hyperparathyroidism. Methods This phase I, randomized study compared thrice-weekly etelcalcetide (5 mg per dose intravenously) and placebo in 33 Chinese adults …

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A Decreased Level of Soluble Klotho Can Predict Cardiovascular Death in No or Mild Abdominal Aortic Calcification Hemodialysis Patients

Hong Cai, Xuying Zhu, Jiayue Lu, Minxia Zhu et autres

Background: Soluble Klotho plays an important role in cardiovascular disease and death in chronic kidney disease (CKD). We assessed the relationship between serum soluble Klotho (sKL) level and outcome in MHD patients. Methods: Soluble Klotho was detected by ELISA. Cox regression analysis …

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P0890EFFICACY AND SAFETY OF CINACALCET IN CHINESE MAINTENANCE HEMODIALYSIS PATIENTS WITH DIFFERENT STAGES OF SECONDARY HYPERPARATHYROIDISM: INTERIM ANALYSIS RESULTS OF ACTIVE STUDY

Aili Jiang, Ping Fu, Guanqing Xiao, JianMing Ye et autres

Abstract Background and Aims Chronic kidney disease (CKD) is a major public health issue worldwide including in China. One of the most common complication in advanced Chronic kidney disease (CKD) is secondary hyperparathyroidism (SHPT). Reports show higher risk of bone fracture, cardiovascular …

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Abdominal aortic calcification score as a predictor of clinical outcome in peritoneal dialysis patients: a prospective cohort study

Dahua Ma, Hao Yan, Xiaoxiao Yang, Zanzhe Yu et autres

BACKGROUND: Abdominal aortic calcification assessed by X-ray is recommended to evaluate vascular calcification in dialysis patients. It has been shown that abdominal aortic calcification score (AACS) is a predictor of adverse outcomes in hemodialysis patients, but evidence regarding its prognostic value in …

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Association of abdominal aortic calcification estimated by plain radiography with outcomes in haemodialysis patients: A 6‐year follow‐up study

Xuying Zhu, Hong Cai, Minxia Zhu, Yaping Zhan et autres

AIM: Vascular calcification has played a vital role in increasing the prevalence of cardiovascular disease (CVD) and mortality in maintenance haemodialysis (MHD) patients. This study is aimed at exploring the prognostic value of abdominal aortic calcification (AAC) estimated by plain lateral abdominal …

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