Accès ouvert
2026
article
OpenAlex
Jianing Wang, Junbao Xu, Xiaoqing Ma, Qianqian Wang et autres
Radiotherapy is essential for local tumor control, and increasing evidence highlights its ability to trigger systemic immune responses. However, the integration of this systemic activation into clinical treatment regimens remains limited. The immunosuppressive environment in the tumor microenvironment (TME) is a key …
cn
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Accès ouvert
2026
article
OpenAlex
Zhimei Huang, Jiayao Zhao, Qinqin Zhang, Yu Luo et autres
To investigate the effects of Mucin 1 (MUC1) in human triple-negative breast cancer MDA-MB-231cells, the MDA-MB-231 cell line with MUC1 knockout (231-MUC1-KO) was constructed by CRISPR/Cas9 gene editing. Cell proliferation was evaluated using EDU and colony formation assays, and cell migration and …
cn
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Accès ouvert
2025
article
OpenAlex
Zhengchun Liu, Jianing Wang, Peizhen Geng, Yuan Yuan et autres
Abstract Background NDC80 is pivotal in cell division, particularly in regulating the G2/M transition and mitotic progression. Recent studies have demonstrated that NDC80 is significantly overexpressed in multiple solid tumors. Further analysis has suggested that its high expression is significantly associated with …
cn
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2025
article
OpenAlex
Wei Jiang, Bin Zhang, Yixin Su, Jiän Zhang et autres
e18019 Background: Nasopharyngeal carcinoma (NPC) patients with T4 or N2–3 or lymph node >3cm diseases have a high risk of metastasis. This study aimed to evaluate the efficacy and safety of adjuvant apatinib in high-risk NPC. Methods: This open-label randomized clinical trial …
cn
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Accès ouvert
2024
article
OpenAlex
Jiankang Wang, Zhengchun Liu, Lina Wei, Changyan Shao et autres
This study aimed to assess the antibacterial and antioxidant properties of both crude polyphenol extract (CPE) and purified polyphenol extract (PPE) obtained from Fuji apple pomace. The antibacterial capacity of both extracts against Staphylococcus aureus was investigated by evaluating the inhibition zones, …
cn
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Accès ouvert
2024
article
OpenAlex
Jinxuan Dai, Bin Zhang, Yixin Su, Yufei Pan et autres
Importance: Induction chemotherapy plus concurrent chemoradiotherapy is recommended for locoregionally advanced nasopharyngeal carcinoma but is associated with higher rates of acute toxic effects and low compliance. Evidence on de-escalating treatment intensity after induction chemotherapy is limited. Objective: To assess if radiotherapy was …
cn
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Accès ouvert
2024
article
OpenAlex
Yunyan Mo, Yufei Pan, Bin Zhang, Jian Zhang et autres
Background: Preclinical studies demonstrated that immune checkpoint inhibitors combined with antiangiogenic drugs have a synergistic anti-tumor effect. This present phase II trial aimed to evaluate the efficacy and safety of apatinib combined with camrelizumab in patients with recurrent/metastatic nasopharyngeal carcinoma (RM-NPC). Methods: …
cn
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Accès ouvert
2023
article
OpenAlex
Peizhen Geng, Yuhua Chi, Yuan Yuan, Maoquan Yang et autres
Triple-negative breast cancer (TNBC) is highly aggressive and does not express estrogen receptor (ER), progesterone (PR), or human epidermal growth factor receptor 2 (HER2). It has a poor prognosis, and traditional endocrine and anti-HER2 targeted therapies have low efficacy against it. In …
cn
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2022
conference-abstract
OpenAlex
Yunyan Mo, Yufei Pan, Bin Zhang, Jian Zhang et autres
e18025 Background: Our previous study demonstrated that apatinib has preliminary clinical benefit in recurrent and/or metastatic nasopharyngeal carcinoma (RM-NPC). Preclinical studies showed the combination of immune checkpoint inhibitors and antiangiogenic drugs produces a synergistic effect in anti-tumor activity. This phase 2 trail …
cn
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Accès ouvert
2021
article
OpenAlex
Tingting Zhang, Meng Michelle Xu, Jinglin Mi, Hui Yang et autres
OBJECTIVE: Whether the original dosimetric constraints of neuro-optic structures (NOS) are appropriate for patients with nasopharyngeal carcinoma (NPC) undergoing intensity-modulated radiotherapy (IMRT) remains controversial. The present study compared the survival rates and radiation-induced optic neuropathy (RION) occurrence between T4 NPC patients whose …
cn
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Accès ouvert
2021
article
OpenAlex
Zhengchun Liu, Xiuli Liu, Rui Cai, Meilian Liu et autres
) were possible independent prognostic markers for patients with bladder cancer. Multiple gene set enrichment analysis of individual genes showed strong correlations with stromal and immune interactions, indicating that these nine genes may be related to carcinogenesis, invasion, and metastasis of bladder …
cn
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Accès ouvert
2020
article
OpenAlex
Chaozhi Tang, Jiakang Ma, Xiuli Liu, Zhengchun Liu
BACKGROUND: Bladder cancer (BLCA) is the fifth most common type of cancer worldwide, with high recurrence and progression rates. Although considerable progress has been made in the treatment of BLCA through accurate typing of molecular characteristics, little is known regarding the various …
cn
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