Siyu Wu

Comparative chloroplast genomics of Ajania sericea and sympatric Asteraceae species identifies shared candidate molecular features associated with alpine adaptation

Hongting Yang, Siyu Wu, He Qian, Haoxi Xin et autres

Ajania sericea is endemic to the Dali region of Yunnan and is currently the southernmost known member of the genus Ajania worldwide. It co-occurs with Aster brachytrichus , Anaphalis pannosa , and Leontopodium dedekensii in alpine habitats of northwestern Yunnan, where plants …

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Identification and functional characterization of a novel antiviral chicken interferon-υ

Siyu Wu, Qiwen Huang, Fangyuan Yang, Jieshi Yu et autres

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Astragalus polysaccharides mitigate heat stress and enhance rabbit does fertility and growth of kits via the gut–short chain fatty acids axis

Yanya Wang, Yan Chang, Biyan He, Chenjun Wang et autres

The aim of this study was to investigate the effects of dietary Astragalus polysaccharides (APS) on reproductive performance, gut microbiota, short-chain fatty acids (SCFAs) of reproducing does, and growth of sucking rabbits (kits) under heat stress conditions. A total of 460 Hyla …

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Single-cell transcriptomic landscape of keratinocyte transformation from actinic keratosis to skin carcinoma

Tao Xu, Zhongzhi Wang, Hao Wu, Yuanjie Zhu et autres

keratinocyte subpopulation (Ker-6) displayed an increasing copy number variation burden and activation of tumor-associated pathways. Ligand-receptor analysis indicated that Ker-6 keratinocytes engage proliferative T cells via the interleukin (IL)-13/IL13RA1/IL4R signaling axis. Functional assays using IL13RA1 and IL4R knockdown confirmed that IL-13 signaling …

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Altitude‐ and Sex‐Specific Telomere Dynamics in the Montane Salamander Pachytriton cheni

Jiayi Shi, Zhirong He, Qingyan Sun, Siyu Wu et autres

Environmental stressors and sex-specific life-history strategies synergistically shape senescence patterns in ectotherms, yet their interactive effects on telomere dynamics remain poorly understood. This study investigates how altitude-related environmental factors and sexual dimorphism drive telomere length variation in the montane salamander Pachytriton cheni …

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A New Species of Pachytriton (Amphibia: Caudata: Salamandridae) from Anhui, China

Zhirong He, Siyu Wu, Shanqing Wang, Li Ma et autres

China is a global hotspot for amphibian biodiversity, yet under-explored montane regions harbor undiscovered cryptic species. Using integrative taxonomy, we describe a new salamandrid species, Pachytriton cheni sp. nov., from Qingliangfeng Nature Reserve, Anhui. Phylogenetic analyses of mitochondrial (ND2, cytb) and nuclear …

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Effect of Galls on the Metabolism of Chrysanthemum Species Based on Metabolomic Profiling

Hong Yu Yang, Wenmiao Li, He Qian, Siyu Wu et autres

INTRODUCTION: Galls, which are abnormal or protruding tissues, form when insects bite plant cells and serve as evidence for understanding plant-insect interactions. OBJECTIVES: This study is aimed at understanding the interactions between Chrysanthemum species and insects at the metabolomic level and to …

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Gut microbiota has the potential to improve health of menopausal women by regulating estrogen

Haiqiang Wang, Fan Shi, Lihong Zheng, Wenhui Zhou et autres

Menopause is an age-related loss of ovarian function. As a woman enters menopause, the estrogen produced by her ovaries decreases, which will adversely affect women's health. The symptoms related to menopause are related to the imbalance of gut microbiota. Studies have shown …

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Serum growth differentiation factor 15 associates with extra-glandular manifestations and disease activity of primary Sjögren’s syndrome

Jinfang Fu, Wanchan Peng, Qiong Wu, Yunli Zhang et autres

Recent interest in growth differentiation factor 15 (GDF15) has been further heightened by its association with rheumatic diseases. GDF15 has been extensively studied as a potential diagnostic and prognostic biomarker. However, no direct evidence currently links GDF15 to primary Sjögren's syndrome (pSS). …

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Efficient haploid induction in Arabidopsis thaliana by fine-tuning CENH3 function

Huan Yang, Ruihua Zhang, Siyu Wu, Shuai Yue et autres

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Research Status and Prospect of Amphibian Symbiotic Microbiota

Ziyi Wang, Yuting Wang, Zhirong He, Siyu Wu et autres

Amphibians are the most severely threatened vertebrate group in terms of biodiversity. The microbiota that coexist in a mutualistic relationship with amphibians play a crucial role in shaping their health status, reproductive efficiency, and environmental adaptability. Understanding the relationship between amphibians and …

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Reshape the Fates of Treg and CD8+T Cells Through IL‐2Rα by Synergizing Divergent Receptor‐Biased IL‐2 PEGylates

Jiaqi Sun, Lingfeng Guo, Dezhong Ji, Mengfan Yu et autres

Clinical trials of receptor-biased interleukin-2 (IL-2) variants in cancer therapy show limited efficacy. To investigate, we re-evaluated divergent receptor-biased IL-2 PEGylates (generated via site-specific PEGylation at residues D20 (not-β) and Y45 (not-α)), alone or in combination. Results showed the not-α variant (Y45) …

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