Shengwei Li

Evolution’s double-edged sword: SARS-CoV-2 adaptation in HIV reveals nature’s safety valve

Shengwei Li, Yunze Niu, Jingyuan Ning

In their Article published in The Lancet Microbe, Joseline M Velasquez-Reyes and colleagues present a remarkable chronicle of SARS-CoV-2 evolution spanning 750 days in an individual with untreated HIV, offering unprecedented insights into viral adaptation dynamics that challenge the current understanding of …

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Stability and Generalization of Asynchronous SGD: Sharper Bounds Beyond Lipschitz and Smoothness

Xiaoge Deng, Tao Sun, Shengwei Li, Xicheng Lu

Towards Understanding the Generalizability of Delayed Stochastic Gradient Descent

Xiaoge Deng, Li Shen, Shengwei Li, Tao Sun et autres

Stochastic gradient descent (SGD) performed in an asynchronous manner plays a crucial role in training large-scale machine learning models. However, the generalization performance of asynchronous delayed SGD, which is an essential metric for assessing machine learning algorithms, has rarely been explored. Existing …

Stability-Based Generalization Analysis of the Asynchronous Decentralized SGD

Xiaoge Deng, Tong Sheng Sun, Shengwei Li, Dongsheng Li

The generalization ability often determines the success of machine learning algorithms in practice. Therefore, it is of great theoretical and practical importance to understand and bound the generalization error of machine learning algorithms. In this paper, we provide the first generalization results …

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Genesis of the Heihaibei gold deposit in the East Kunlun Orogenic Belt, China: Evidence from in situ trace elements of gold-bearing sulfides and stable isotopes

Diange Cong, Yuan Feng, T. Pan, Bingzhang Wang et autres

The Heihaibei gold deposit, located in the south part of the East Kunlun orogenic belt (EKOB), is a newly discovered gold deposit, with similar tectonic setting and geological characteristics with typical orogenic gold deposits in the orogenic belt. The aim of this …

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Immunological classification of hepatitis B virus-positive hepatocellular carcinoma by transcriptome analysis

Shengwei Li, Li-Fan Han, Yin He, Xiaosheng Wang

BACKGROUND: Hepatitis B virus (HBV) infection is a major factor responsible for HBV+ hepatocellular carcinoma (HCC). AIM: An immunological classification of HBV+ HCC may provide both biological insights and clinical implications for this disease. METHODS: Based on the enrichment of 23 immune …

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Associations between disrupted functional brain network topology and cognitive impairment in patients with rectal cancer during chemotherapy

Yesong Guo, Siwen Liu, Fei Yan, Na Yin et autres

Introduction Cognitive impairment has been identified in patients with non-central nervous system cancer received chemotherapy. Chemotherapy-induced changes in the brain are considered as the possible causes of the cognitive deficits of patients. This study aimed to explore chemotherapy-related functional brain changes and …

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Evaluation of the Effects of Pterygium and Aging on Limbal Structure Using Optical Coherence Tomography

Shengwei Li, Haozhe Yu, Pu Wang, Yun Feng

Previous studies suggest that regions of corneal limbus may possess structural differences. We aimed to investigate the limbal changes associated with pterygium and aging via optical coherence tomography (OCT). Palisades of Vogt epithelial thickness (POV-ET) and Bowman's membrane epithelial thickness (BM-ET) were …

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Corrigendum: Identification of breast cancer immune subtypes by analyzing bulk tumor and single cell transcriptomes

Jia Yao, Shengwei Li, Xiaosheng Wang

[This corrects the article DOI: 10.3389/fcell.2021.781848.].

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Chemotherapy-induced functional brain abnormality in colorectal cancer patients: a resting‐state functional magnetic resonance imaging study

Siwen Liu, Yesong Guo, Jie Ni, Na Yin et autres

Introduction: Chemotherapy-induced cognitive impairment (i.e., "chemobrain") is a common neurotoxic side-effect experienced by many cancer survivors who undergone chemotherapy. However, the central mechanism underlying chemotherapy-related cognitive impairment is still unclear. The purpose of this study was to investigate the changes of intrinsic …

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Subtyping of sarcomas based on pathway enrichment scores in bulk and single cell transcriptomes

Shengwei Li, Qian Liu, Haiying Zhou, Hui Juan Lu et autres

BACKGROUND: Sarcomas are highly heterogeneous in molecular, pathologic, and clinical features. However, a classification of sarcomas by integrating different types of pathways remains mostly unexplored. METHODS: We performed hierarchical clustering analysis of sarcomas based on the enrichment scores of 14 pathways involved …

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Subtyping of Human Papillomavirus-Positive Cervical Cancers Based on the Expression Profiles of 50 Genes

Xiaojun Zhu, Shengwei Li, Jiangti Luo, Zhi Li et autres

Background: Human papillomavirus-positive (HPV+) cervical cancers are highly heterogeneous in molecular and clinical features. However, the molecular classification of HPV+ cervical cancers remains insufficiently unexplored. Methods: Based on the expression profiles of 50 genes having the largest expression variations across the HPV+ …

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