Xiaosheng He

Abstract 2390: Noninvasive early detection of colorectal cancer by a deep read-level model for accurate identification of methylation-specific circulating tumor DNA

Ping Lan, Xiaosheng He, Hong Xu, Zhijian Xu et autres

Abstract Background: Liquid biopsy enables noninvasive cancer screening through the detection of plasma circulating tumor DNA (ctDNA), yet faces challenges due to the low ctDNA abundance in plasma, especially in early-stage cancer. Precise discrimination of ctDNA fragment can significantly enrich tumor signals …

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IDDF2024-ABS-0336 Identification of plasma protein biomarkers for colorectal cancer diagnosis and prognosis

Dong Hang, Xinyi Liu, Chengqu Fu, Le Yi Wang et autres

Background The incidence and mortality of colorectal cancer (CRC) have been steadily rising in many countries. There is an urgent need to identify convenient, reliable biomarkers for CRC early diagnosis and precise prognostic prediction. Methods Untargeted plasma proteomics profiling by liquid chromatography …

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Data from Associations between 25 Lung Cancer Risk–Related SNPs and Polycyclic Aromatic Hydrocarbon–Induced Genetic Damage in Coke Oven Workers

Xiayun Dai, Siyun Deng, Tian Wang, Gaokun Qiu et autres

Abstract Background: Genome-wide association studies (GWAS) have identified multiple single-nucleotide polymorphisms (SNP) associated with lung cancer. However, whether these SNPs are associated with genetic damage, a crucial event in cancer initiation and evolution, is still unknown. We aimed to establish associations between …

Supplementary Tables 1 through 4 from Associations between 25 Lung Cancer Risk–Related SNPs and Polycyclic Aromatic Hydrocarbon–Induced Genetic Damage in Coke Oven Workers

Xiayun Dai, Siyun Deng, Tian Wang, Gaokun Qiu et autres

PDF - 141K, Table S1. The relationships of age groups, gender, and smoking status to the levels of PAH metabolites, BPDE-Alb Adducts and genetic damage. Table S2. Levels of genetic damage in coke oven workers according to lung cancer risk-related SNPs. Table …

Data from Associations between 25 Lung Cancer Risk–Related SNPs and Polycyclic Aromatic Hydrocarbon–Induced Genetic Damage in Coke Oven Workers

Xiayun Dai, Siyun Deng, Tian Wang, Gaokun Qiu et autres

Abstract Background: Genome-wide association studies (GWAS) have identified multiple single-nucleotide polymorphisms (SNP) associated with lung cancer. However, whether these SNPs are associated with genetic damage, a crucial event in cancer initiation and evolution, is still unknown. We aimed to establish associations between …

Supplementary Tables 1 through 4 from Associations between 25 Lung Cancer Risk–Related SNPs and Polycyclic Aromatic Hydrocarbon–Induced Genetic Damage in Coke Oven Workers

Xiayun Dai, Siyun Deng, Tian Wang, Gaokun Qiu et autres

PDF - 141K, Table S1. The relationships of age groups, gender, and smoking status to the levels of PAH metabolites, BPDE-Alb Adducts and genetic damage. Table S2. Levels of genetic damage in coke oven workers according to lung cancer risk-related SNPs. Table …

Downregulation of microRNA‐124‐3p promotes subventricular zone neural stem cell activation by enhancing the function of BDNF downstream pathways after traumatic brain injury in adult rats

Enming Kang, Yibin Jia, Jia‐You Wang, Guan‐Yi Wang et autres

AIMS: In this study, the effect of intracerebral ventricle injection with a miR-124-3p agomir or antagomir on prognosis and on subventricular zone (SVZ) neural stem cells (NSCs) in adult rats with moderate traumatic brain injury (TBI) was investigated. METHODS: Model rats with …

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HBO Alleviates Neural Stem Cell Pyroptosis via lncRNA‐H19/miR‐423‐5p/NLRP3 Axis and Improves Neurogenesis after Oxygen Glucose Deprivation

Yuqin Ye, Zhusheng Feng, Shilai Tian, Yongxiang Yang et autres

Due to the limited neurogenesis capacity, there has been a big challenge in better recovery from neurological dysfunction caused by stroke for a long time. Neural stem cell (NSC) programmed death is one of the unfavorable factors for neural regeneration after stroke. …

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Abstract 2840: HK1 induces epithelial-mesenchymal transition and promotes metastasis of colorectal cancer

Xiaobin Zheng, Huashan Liu, Xiaoli Zhong, Xuanhui Liu et autres

Abstract Hexokinase 1 (HK1) has been implicated in tumorigenesis. However, its role in tumor metastasis and progression has not been evaluated. The aim of this study is to evaluate the role of HK1 in the metastasis in CRC. Methods: The expression level …

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Su027 DNA REPAIR-RELATED GENE SIGNATURE IN PREDICTING PROGNOSIS OF COLORECTAL CANCER PATIENTS

Min‐Yi Lv, Wei Wang, Du Cai, Min‐Er Zhong et autres

Identification of key methylation differentially expressed genes in posterior fossa ependymoma based on epigenomic and transcriptome analysis

Guanyi Wang, Yibin Jia, Yuqin Ye, Enming Kang et autres

Abstract Background Posterior fossa ependymoma (EPN-PF) can be classified into Group A posterior fossa ependymoma (EPN-PFA) and Group B posterior fossa ependymoma (EPN-PFB) according to DNA CpG island methylation profile status and gene expression. EPN-PFA usually occurs in children younger than 5 …

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Niche Cells Crosstalk In Neuroinflammation After Traumatic Brain Injury

Yibin Jia, Guanyi Wang, Yuqing Ye, Enming Kang et autres

Traumatic brain injury (TBI) is recognized as the disease with high morbidity and disability around world in spite of the work ongoing in neural protection. Due to heterogeneity among the patients, it's still hard to acquire satisfying achievements in clinic. Neuroinflammation, which …

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