A Mitchell

Troponin antibodies and macrotroponin: a common cause of troponin I elevation in elite endurance athletes

S. Rowe, Kalayani McKubre, A Mitchell, Luke Spencer et autres

Abstract Background and Aims Elevations in cardiac troponin I (cTnI), a marker of myocardial injury, have been frequently observed in athletes after intense exercise. cTnI autoantibodies (cTnI Ab) and macrotroponin complexes can confound assessment, and we hypothesised that they may explain the …

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Bradycardia in Athletes: Prevalence, Mechanisms, and Risks

Paolo D’Ambrosio, J De Paepe, Luke Spencer, Monique Ohanian et autres

BACKGROUND: Sinus bradycardia is a well-recognized physiological adaptation in endurance athletes, primarily attributed to sinus node remodeling or increased vagal modulation. Although genetic influences on resting heart rate (HR) have been observed, the genetic contribution to athletic bradycardia has not been elucidated. …

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Little evidence of cardiac involvement in Mild and Moderate Swimming- Induced Pulmonary Oedema (SIPE)

Anniina Lindqvist, Doug Hacking, Leah Wright, Brian Cowie et autres

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Left atrioventricular ratio (LA:LV): using left ventricular size as the reference for identifying maladaptive left atrial remodelling

Luke Spencer, Sara Ferreira, Maurício Milani, S. Rowe et autres

INTRODUCTION: Remodelling of the left atrium (LA) and left ventricle (LV) occurs in response to pathological and physiological stimuli, yet their inter-dependence is often overlooked in clinical practice. The left atrioventricular ratio (LA:LV)-the ratio of maximal LA end-systolic volume (LAESV) to LV …

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Myocardial fibrosis and its relationship with ventricular arrhythmias and reduced ventricular systolic function in young and veteran endurance athletes

J De Paepe, Paolo D’Ambrosio, Ruben De Bosscher, Youri Bekhuis et autres

AIMS: The prevalence of ventricular fibrosis and its association with ventricular arrhythmias (VAs) and reduced ventricular systolic function in endurance athletes remains unclear. METHODS AND RESULTS: We evaluated 296 young [median age 19 (17-22)] and 138 middle-aged [56 (50-60)] male endurance athletes, …

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Diagnostic accuracy of different exercise blood pressure metrics in identifying hypertension on 24-h ambulatory blood pressure monitoring in athletes

Kristel Janssens, Stephen Foulkes, Paolo D’Ambrosio, A Mitchell et autres

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The role of lipoprotein(a) in predicting coronary artery disease among ageing endurance athletes and healthy controls

Rik Pauwels, Ruben De Bosscher, J De Paepe, Christophe Dausin et autres

AIMS: Ageing endurance athletes have a higher prevalence of coronary artery disease (CAD) on coronary CT angiography (CCTA) than healthy controls, despite similarly low conventional cardiovascular risk. The predictive value of lipoprotein(a) [Lp(a)] for CAD in these low-risk individuals remains unclear. METHODS: …

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Arrhythmia burden, symptoms and quality of life in female and male endurance athletes with paroxysmal atrial fibrillation: a multicentre cohort study in Norway, Australia and Belgium

Turid Apelland, Jon Magne Letnes, Kristel Janssens, Guido Claessen et autres

OBJECTIVES: To assess atrial fibrillation (AF) burden, symptoms and quality of life (QoL) in endurance athletes with paroxysmal AF. DESIGN: Prospective cohort study. SETTING AND PARTICIPANTS: Otherwise healthy endurance athletes with paroxysmal AF in Norway, Australia and Belgium. The current study presents …

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Mechanistic Insights Into Reduced Arrhythmia Prevalence in Female Endurance Athletes

Paolo D’Ambrosio, J De Paepe, S. Rowe, A Mitchell et autres

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Exercise in Inherited Cardiomyopathies: Optimizing the Dose-Response Curve

Eleanor Rye, A Mitchell, Celine Santiago, André La Gerche et autres

Exercise is generally considered beneficial for cardiovascular health, but for patients with inherited cardiomyopathies, exercise can be a source of anxiety due to concerns about arrhythmia risk and disease progression. In the general population, exercise avoidance can impact cardiometabolic health and diminished …

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Atrial fibrillation in former world-class rowers: role of environmental and genetic factors

D. Flannery, Rodrigo Cánovas, Kristel Janssens, A Mitchell et autres

BACKGROUND AND AIMS: Endurance sport has been associated with an increased risk of atrial fibrillation (AF). The aim of this study was to assess the extent to which this is due to exercise burden or genetic predisposition. METHODS: Former rowers aged 45-80 …

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Markers of atrial myopathy in endurance athletes

Luke Spencer, Paolo D’Ambrosio, S. Rowe, Kristel Janssens et autres

Abstract Background Atrial cardiomyopathy (AtCM) is increasingly recognised as an early substrate for the development of atrial arrhythmias, particularly atrial fibrillation (AF). However, it remains unclear how AtCM markers apply to endurance athletes (EAs) and whether they discriminate AF in this population, …

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