Salman J. Khan

Efficacy and safety of CD3×CD20 bispecific antibodies in Richter transformation: A systematic review of prospective trials and comparative analysis.

Salman J. Khan, Hamza Usman, Seemab Sheikh, Kelvin Rojas et autres

e19095 Background: Richter transformation (RT), the progression of chronic lymphocytic leukemia to aggressive diffuse large B-cell lymphoma, carries poor outcomes. Chemoimmunotherapy (CIT), including R-CHOP, remains commonly used in the frontline setting, while CD19-directed CAR T-cell therapy is used mainly in relapsed/refractory (R/R) …

us (code pays fourni par la source)

Progressive Pulmonary Lesions and Cervical Lymphadenopathy Revealing Large B-cell Lymphoma: A Rare Case Report

Muhammad Rizwan Tariq, Blessing T Ojinna, Efrah Ashraf, Arshia Ahmed et autres

Primary pulmonary and thyroid diffuse large B-cell lymphoma (DLBCL) is an exceptionally rare extranodal manifestation of non-Hodgkin lymphoma and often presents with nonspecific clinical and radiographic features, leading to significant diagnostic challenges. We report a case of a 70-year-old woman with extensive …

pk, us (code pays fourni par la source)

CLO26-108: Efficacy of CAR T Cell Therapy in Extranodal and Nodal Large B-Cell Lymphoma

Salman J. Khan, Hamza Usman, Seemab Sheikh, Mahuri Yalamanchili

us (code pays fourni par la source)

Advanced cardiac imaging in cardiac sarcoidosis: current evidence and future directions

Awais Aslam, Wahab Jahangir Khan, Syed H. Haq, Ifrah Nadeem et autres

Cardiac sarcoidosis (CS) is a rare and complex disease that requires a multidisciplinary approach for diagnosis and treatment. The diagnosis of CS can be confirmed by histological examination of non-caseating granulomas in cardiac or extracardiac tissue, along with supportive clinical and imaging …

us (code pays fourni par la source)

Outcomes with repeat CAR-t cell therapy: A systematic review and meta-analysis

Hafiz Muhammad Asif Javed, Fatima Sial, Farooq Ashraf, Aman Ullah et autres

Abstract Introduction: Chimeric Antigen Receptor (CAR) T-cell therapy has transformed the treatment of relapsed or refractory B-cell malignancies. Repeat CAR T-cell therapy (CART2) is a potential approach for patients with suboptimal response to initial treatment or who relapse. Here we report outcomes …

us, pk (code pays fourni par la source)

Real-world analysis of infection timing and burden in multiple myeloma patients treated with teclistamab

Divya Chukkalore, Phyu Thin Naing, Kelvin Zheng, Richa Thakur et autres

Abstract Background Teclistamab, a BCMA x CD3 bispecific antibody, is a highly effective novel therapeutic option for patients with relapsed/refractory multiple myeloma (RRMM). Clinical trials like MajesTEC-1 show impressive efficacy but also high early infection rates, likely due to immune disruption from …

us, Afrique du Sud (code pays fourni par la source)

Eculizumab for hyperhemolysis syndrome in sickle cell disease: A systematic review and meta-analysis

Moazzam Shahzad, Muhammad Shaheer Mannan, Hafiz Muhammad Asif Javed, Farooq Ashraf et autres

Abstract Background Hyperhemolysis syndrome (HHS) is a rare, potentially fatal transfusion complication seen in patients with sickle cell disease (SCD), characterized by the destruction of both donor and recipient red blood cells, leading to a paradoxical drop in hemoglobin. Eculizumab, a monoclonal …

us, pk (code pays fourni par la source)

POSTER: CLL-1340 Outcomes With Bruton Tyrosine Kinase Inhibitors in Richter’s Transformation Patients: A Systematic Review and Meta-Analysis

Ammad Naeem, Fatima Sial, Salman J. Khan, Aniqa Faraz et autres

CLL-1340: Outcomes With Bruton Tyrosine Kinase Inhibitors in Richter's Transformation Patients: A Systematic Review and Meta-Analysis

Ammad Naeem, Fatima Sial, Salman J. Khan, Aniqa Faraz et autres

Association of antiphospholipid syndrome with infective endocarditis and sepsis induced by Staphylococcus aureus: A U.S. nationwide inpatient sample analysis

Bahy Abofrekha, Jessica Schwartz, Chloé Lahoud, Ahmad Mustafa et autres

Background Antiphospholipid syndrome (APS) predisposes patients to thrombosis and cardiac valve lesions such as Libman-Sacks endocarditis. These vegetations are sterile yet can provide a nidus for infection; the risk of infective endocarditis (IE) and other serious infections in APS patients remains poorly …

us (code pays fourni par la source)

A Case of Pericarditis With Pericardial Effusion Due to Lyme Disease

Osamede Agho, Sara Tariq, Arshia Ahmed, Salman J. Khan et autres

Acute pericarditis with pericardial effusion caused by Lyme disease is very rare and requires excluding other more common possible causes of acute pericarditis. Common causes of acute pericarditis include viral and bacterial infections, connective tissue disorders such as rheumatoid arthritis, systemic lupus …

us, Nigéria (code pays fourni par la source)

Induction chemotherapy for locally advanced sinonasal carcinoma: A systematic review and meta-analysis.

Atif Saleem Butt, Muhammad Fareed Khalid, Ammad Naeem, Salman J. Khan et autres

e18160 Background: Induction chemotherapy (IC) has emerged as a promising approach in the management of locally advanced sinonasal carcinoma. Recent studies have demonstrated that IC can lead to significant tumor reduction, facilitating subsequent definitive treatments such as chemoradiotherapy (CRT) or surgery, and …

us (code pays fourni par la source)