Jie Yang

RNA-binding protein PTBP1 mediates HSV-1 attachment and infection through regulation of heparan sulfate 3-O-sulfotransferase gene expression

Weikang Sun, Mengyu Zhang, Ruilin Wang, Jie Yang et autres

BACKGROUND: The RNA-binding protein polypyrimidine tract-binding protein 1 (PTBP1), also known as heterogeneous nuclear ribonucleoprotein I (hnRNP I), mediates gene expression through splicing regulation. Its role in virus infection is undefined. RESULTS: We show that genetic ablation of PTBP1 renders cell resistant …

cn, bd (code pays fourni par la source)

An Efficient Homologous Recombination-based in situ Protein-labeling Method in Verticillium dahliae

Jie Yang, Mengran Liu, Yue Jiao, Hui‐Shan Guo et autres

Accurate determination of protein localization, levels, or protein-protein interactions is pivotal for the study of their function, and in situ protein labeling via homologous recombination has emerged as a critical tool in many organisms. While this approach has been refined in various …

cn (code pays fourni par la source)

CircMIRLET7BHG, upregulated in an m6A-dependent manner, induces the nasal epithelial barrier dysfunction in allergic rhinitis pathogenesis

Jiabin Zhan, Jie Yang, Jing Zheng, Yanyan Qi et autres

cn (code pays fourni par la source)

Remodeling periodontal osteoimmune microenvironment through MAPK/NFκB phosphorylation pathway of macrophage via intelligent ROS scavenging

Xinyi Qiu, Haoran Peng, Yue Zhao, Yijun Yu et autres

cn (code pays fourni par la source)

[Targeting microRNA-125b inhibited the metastasis of Alisertib resistance cells through mediating p53 pathway].

Fan Yang, Fang Zheng, X X Liu, Na Sun et autres

Silencing of p53 by miR-125b could be one of the mechanisms that contributes to Alisertib resistance. Targeting miR-125b could be a strategy to overcome Alisertib resistance.

cn (code pays fourni par la source)

Remodeling Periodontal Osteoimmune Microenvironment Through MAPK/NFκB Phosphorylation Pathway of Macrophage via Intelligent ROS-scavenging

Xinyi Qiu, Haoran Peng, Yue Zhao, Yijun Yu et autres

Abstract Periodontitis is an inflammatory disorder which leads to the defect of tooth-supporting tissue, especially in alveolar bone. During this process, the polarization behavior of macrophages affects immune inflammation and bone regeneration in which reactive oxygen species(ROS) play an essential role. ROS …

cn (code pays fourni par la source)

Rational Design of Multifunctional Micelles Against Doxorubicin-Sensitive and Doxorubicin-Resistant MCF-7 Human Breast Cancer Cells [Retraction]

Wei Hong, Hong Shi, Mingxi Qiao, Xiang Gao et autres

[This retracts the article DOI: 10.2147/IJN.S127417.].

[TSTA3 gene promotes esophageal cancer invasion through MAPK-ERK pathway and downstream MMP2/9].

Erxiang Xu, Jie Yang, L Zhang

目的： 探讨TSTA3基因在食管鳞状细胞癌（ESCC）侵袭中的作用及相关机制。 方法： 选择ESCC细胞KYSE150、ECA109，构建过表达TSTA3基因的KYSE150-TSTA3-WT组和ECA109-TSTA3-WT组，以及空白对照组（KYSE150-NC组和ECA109-NC组）。对各组细胞进行转录组测序，依据KEGG数据库进行差异基因的富集分析。蛋白质印迹法和免疫组织化学法检测目标蛋白的表达，划痕实验检测细胞迁移能力，Transwell实验检测细胞侵袭能力，明胶酶谱法检测基质金属蛋白酶（MMP）活性。 结果： TSTA3基因过表达对ESCC细胞的增殖无明显影响，但可以增强ESCC细胞的侵袭能力（P<0.05）。TSTA3过表达前后KYSE150细胞的转录组测序共鉴定出817种基因表达上调，584种基因表达下调，差异基因主要富集在细胞外基质-受体相互作用、Jak-STAT通路、苯丙氨酸代谢、MAPK信号通路等（P<0.05）。与对照组相比，过表达野生型TSTA3基因的ECA109和KYSE150细胞中p-ERK蛋白表达水平增高，用MAPK-ERK通路抑制剂U0126处理后，p-ERK蛋白表达水平降低，且U0126处理可逆转TSTA3过表达引起的促侵袭、迁移能力（P<0.05）。MMP2和MMP9在TSTA3过表达的KYSE150、ECA109中表达增高，活性增加；U0126处理后MMP2及MMP9蛋白表达显著降低，活性下降（P<0.05）。 结论： TSTA3基因可能通过MAPK-ERK通路作用于MMP2及MMP9发挥促进ESCC细胞侵袭、迁移的作用。.

cn (code pays fourni par la source)

Cerium oxide nanoparticles loaded nanofibrous membranes promote bone regeneration for periodontal tissue engineering

Shuangshuang Ren, Yi Zhou, Kai Zheng, Xuanwen Xu et autres

Bone regeneration is a crucial part in the treatment of periodontal tissue regeneration, in which new attempts come out along with the development of nanomaterials. Herein, the effect of cerium oxide nanoparticles (CeO2 NPs) on the cell behavior and function of human …

cn, de (code pays fourni par la source)

Upregulation of IL-10 expression inhibits the proliferation of human periodontal ligament stem cells

Yu Liu, Jie Yang, Weibin Sun

The abnormal increase in proliferation rate of human periodontal ligament stem cells (PDLSCs) is considered to be involved in the pathogenesis of periodontitis, a disease in which the IL-10-mediated anti-inflammatory pathway plays a critical role. This study aimed to investigate the involvement …

cn (code pays fourni par la source)

Modification of IL-24 by tumor penetrating peptide iRGD enhanced its antitumor efficacy against non-small cell lung cancer

Jie Yang, Yanhong Wei, Hong Yin, Lin Fang et autres

cn (code pays fourni par la source)

Knockdown of RNF2 enhances the radiosensitivity of squamous cell carcinoma in lung

Jie Yang, Yu Fan, Jinlei Guan, Tao Wang et autres

A previous study has reported that knockdown of RING finger protein 2 (RNF2) increases the radiosensitivity of esophageal cancer cells both in vitro and in vivo. However, the effect of RNF2 knockdown on radiosensitivity in squamous cell carcinoma (SqCC) remains unknown. For …

cn (code pays fourni par la source)