Ying Shi

Meplazumab, a CD147 antibody, for severe COVID-19: a double-blind, randomized, placebo-controlled, phase 3 clinical trial

Huijie Bian, Chen Liang, Zheng Zhang, Aidong Wen et autres

Meplazumab, a humanized CD147 antibody, showed favorable safety and clinical benefits in phase 1 and phase 2/3 seamless clinical studies. Further evaluation of its therapeutic efficacy in patients with severe COVID-19 is needed. In this phase 3 add-on study, we randomized patients …

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Decoding HIV-associated neurocognitive disorders: a new perspective from multimodal connectomics

Zhongkai Zhou, Wei Wang, Hui Li, Ying Shi et autres

Currently, HIV-associated neurocognitive disorders (HAND) remains one of the major challenges faced by people living with HIV (PLWH). HAND involves the vulnerability of neural circuits caused by synaptic degeneration and abnormal synaptic pruning. In recent years, connectomics has been gradually applied to …

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Signaling Effects in Private Firm Acquisitions: The Impact of Venture Capital on Acquisition Discounts

Ying Shi, Takashi Hatakeda

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Regulation of Physical Activity and Sedentary Behavior on the Preventive Effect of Serum 25(OH)D Levels on NAFLD

Jia Wang, Yu‐Xiao Yang, Chen Yang, Ying Shi et autres

Background: Uncertainty exists regarding the effects of physical activity (PA) and sedentary behavior on the connection between serum 25‐hydroxyvitamin D (25(OH)D) levels and nonalcoholic fatty liver disease (NAFLD). This study aims to evaluate these variables’ potential consequences and offers fresh perspectives and …

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Predictive value of left atrial and left ventricular strain for sudden cardiac death risk in hypertrophic cardiomyopathy by feature-tracking CMR

Xinyu Zhu, Pengfei Liu, Ying Shi, Jianxiu Lian et autres

Motivation: The risk stratification for implantable cardioverter-defibrillators (ICD) placement in high-risk patients with hypertrophic cardiomyopathy (HCM) has challenges. Goal(s): The aim of this study is to investigate the connection between left atrial and left ventricular strain and sudden cardiac death (SCD) risk …

ASPP2 deficiency promotes the progression of metabolic dysfunction-associated steatohepatitis via ACSL4 upregulation

Jinming Wang, Quanwei Li, Yunfei Huo, Xiaoni Liu et autres

As a member of the p53-binding protein family, apoptosis-stimulating protein p53 2 (ASPP2) is closely related to autophagy and apoptosis. However, the mechanistic role of ASPP2 in the development of metabolic dysfunction-associated steatohepatitis (MASH) remains elusive. Therefore, we investigated the role and …

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Left atrial and left ventricular strain in feature-tracking cardiac magnetic resonance for predicting patients at high risk of sudden cardiac death in hypertrophic cardiomyopathy

Xinyu Zhu, Ying Shi, Jianxiu Lian, Honghu Shen et autres

Background: Sudden cardiac death (SCD) represents the most severe complication of hypertrophic cardiomyopathy (HCM). The risk stratification of SCD in patients with HCM remains a subject of ongoing debate, and the utility of left atrial (LA) and left ventricular (LV) myocardial strain …

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The Feasibility of Left Ventricular Strain and Strain Rate for Evaluating Hypertrophic Cardiomyopathy with Risk Factors of Sudden Cardiac Death by Feature-Tracking CMR

Xinyu Zhu, Yuan Tian, Ying Shi, Jianxiu Lian et autres

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Highly sensitive single-molecule counting technology for cytokeratin 18 detection in non-alcoholic fatty liver disease using novel antibodies

Pengxiang Liu, Haijing Ben, J. Guo, Lijun Pang et autres

Non-alcoholic fatty liver disease (NAFLD) affects approximately 25 % of the global population, presenting a significant threat to human health and imposing a substantial economic burden on society. Cytokeratin 18 (CK18) has emerged as a promising non-invasive biomarker for early detection of …

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The Advances in the Application of Music Therapy in the Treatment of Children with Attention Deficit Hyperactivity Disorder (ADHD)

Ying Shi, Huang Meilin, Wang Xuejiao, Wang Haifei et autres

Attention Deficit Hyperactivity Disorder (ADHD) is one of the common neurodevelopmental disorders, characterized by symptoms of inattention, hyperactivity, and impulsivity. Interventions for ADHD typically rely on medication, but parents’ concerns over medication side effects often lead to compliance issues. In recent years, …

The hepatitis B virus promotes the progression of non-alcoholic fatty liver disease through incomplete autophagy

Yang Wang, Jiaxi Li, Shanshan Wang, Yuheng Pang et autres

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Immunological and metabolic characteristics of the Omicron variants infection

Jiejie Geng, Xu Yang, Kun Wang, Ke Wang et autres

The Omicron variants of SARS-CoV-2, primarily authenticated in November 2021 in South Africa, has initiated the 5th wave of global pandemics. Here, we systemically examined immunological and metabolic characteristics of Omicron variants infection. We found Omicron resisted to neutralizing antibody targeting receptor …

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