Ya-Hsin Chou

Depressive Symptoms, Social Support, and Health-Related Quality of Life of Patients After Lung Transplantation

Chi-Hsuan Fan, Wei‐Hsun Chen, Ya-Hsin Chou, Chia-Hui Cheng et autres

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User-Friendly Chatbot to Mitigate the Psychological Stress of Older Adults During the COVID-19 Pandemic: Development and Usability Study

Ya-Hsin Chou, Chemin Lin, Shwu‐Hua Lee, Yen-Fen Lee et autres

BACKGROUND: To safeguard the most vulnerable individuals during the COVID-19 pandemic, numerous governments enforced measures such as stay-at-home orders, social distancing, and self-isolation. These social restrictions had a particularly negative effect on older adults, as they are more vulnerable and experience increased …

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Potential Mobile Health Applications for Improving the Mental Health of the Elderly: A Systematic Review

Ya-Hsin Chou, Chemin Lin, Shwu‐Hua Lee, Ya-Wen Chang Chien et autres

The rapid aging of the global population presents challenges in providing mental health care resources for older adults aged 65 and above. The COVID-19 pandemic has further exacerbated the global population's psychological distress due to social isolation and distancing. Thus, there is …

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User-Friendly Chatbot to Mitigate the Psychological Stress of Older Adults During the COVID-19 Pandemic: Development and Usability Study (Preprint)

Ya-Hsin Chou, Chemin Lin, Shwu‐Hua Lee, Yen-Fen Lee et autres

BACKGROUND To safeguard the most vulnerable individuals during the COVID-19 pandemic, numerous governments enforced measures such as stay-at-home orders, social distancing, and self-isolation. These social restrictions had a particularly negative effect on older adults, as they are more vulnerable and experience increased …

Subjective and objective assessments of sleep problems in children with attention deficit/hyperactivity disorder and the effects of methylphenidate treatment

Wei‐Chih Chin, Yu‐Shu Huang, Ya-Hsin Chou, Chih-Huan Wang et autres

BACKGROUND: to investigate the sleep problems in children with different ADHD presentations and effects of methylphenidate (MPH) on the sleep problems of children with ADHD by both subjective and objective measurements. METHODS: 71 children with ADHD and 30 controls were included. 35 …

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Dimensionality of the Chinese hospital anxiety depression scale in psychiatric outpatients: Mokken scale and factor analyses

Chin‐Pang Lee, Ya-Hsin Chou, Chia-Yih Liu, Ching‐I Hung

OBJECTIVE: The hospital anxiety and depression scale (HADS) is a widely used scale of anxiety and depression. However, recent studies have challenged the bi-dimensional scoring of the HADS. The present study was to examine the dimensionality of the Chinese HADS. METHODS: We …

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Construct validity of the Depression and Somatic Symptoms Scale: evaluation by Mokken scale analysis

Ya-Hsin Chou, Chin‐Pang Lee, Chia-Yih Liu, Ching‐I Hung

Objective: Previous studies of the Depression and Somatic Symptoms Scale (DSSS), a free scale, have been based on the classical test theory, and the construct validity and dimensionality of the DSSS are as yet uncertain. The aim of this study was to …

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Adult TBI-3Parahippocampal Volume in Mild TBI Subjects: The Impact of Premorbid and Post-injury Depression

C Schwimmer, Shannon M. McNally, Thokchom Nandira Devi, Dung Vu Hanh Pham et autres

Objective: Is premorbid depression or post-injury depression related to differential volume loss in mild Traumatic Brain Injury (TBI)? Several studies suggest a neurotoxic effect of depression on left hemisphere hippocampal volume. Post-TBI depression also has been associated with reduced hippocampal volume. Method: …

Genetic and DAT imaging studies of familial parkinsonism in a Taiwanese cohort

Chunyan Lu, Ya-Hsin Chou, Yi-Hsin Weng, R. S. Chen

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人類乳癌細胞株中多氯聯苯對雌性激素(17β-estradiol)所誘發細胞毒性、核酸損害與基因表現失衡之影響

周雅炘, Ya-Hsin Chou

本研究主旨在於探討多氯聯苯(PCB126與PCB153)對雌性激素(17β-estrodiol，E2)於人類乳癌細胞株ERα(+)/MCF-7與ERα(-)/MDA-MB-231，誘發基因表現失衡、氧化壓力、核酸氧化損害、及細胞毒性之影響。研究結果顯示，E2、PCB126、PCB153於MCF-7和MDA-MB-231細胞中所誘發之細胞毒性皆具有時間及濃度效應，且在此兩株人類乳癌細胞中，PCB153所誘發之細胞毒性明顯大於PCB126。研究結果顯示，在不引起細胞毒性濃度下，E2於MDA-MB-231細胞中會誘發細胞內ROS增加，且E2濃度愈高，ROS濃度增加愈明顯，若預處理PCB126則不會影響由E2所誘發之ROS生成，但細胞若預處理PCB153，則會抑制由E2所誘發之ROS生成，而α-naphthoflavone (a CYP1A1/1B1 inhibitor)能有效地抑制E2於MDA-MB-231細胞中所造成之ROS生成；此外，在MCF-7細胞中，E2不能誘發細胞內ROS的生成，細胞若預處理PCB126，亦不能促進E2誘發細胞內ROS量增加，但細胞若預處理PCB153後，則能促進E2誘發細胞內ROS量增加。更進一步研究指出，E2於正常生理濃度(1-10 nM)即可誘發MDA-MB-231細胞DNA strand breaks之形成，進而活化PARP-1 [poly(ADP-ribose) polymerase-1]，誘發細胞內NAD+及NAD(P)H濃度下降，細胞若預處理PCB126後，對於E2所誘發之PARP-1之活化並無影響，但細胞若預處理PCB153，則會抑制由E2所誘發之PARP-1之活化。E2 (0.1 nM-10 nM)於MCF-7細胞中並無法誘發NAD(P)H下降，而MCF-7細胞預處理PCB153後，能促進E2誘發細胞內NAD(P)H濃度下降。由半定量之RT-PCR結果顯示，E2可誘發MDA-MB-231細胞中CYP1A1、CYP1B1、hOGG1和XRCC1之基因表現量，預處理PCB153可抑制由E2所誘發CYP1A1、CYP1B1、hOGG及XRCC1 mRNA之基因表現量；而單獨的PCB153與E2可誘發MCF-7細胞中CYP1A1和CYP1B1之基因表現，預處理PCB153可促進由E2所誘發CYP1A1之基因表現量，單獨之PCB153可抑制MCF-7細胞中hOGG1及XRCC1之基因表現量。由RT-PCR結果顯示，PCB153之暴露會影響E2代謝與核酸修補相關基因之表現。綜合以上結果顯示，共平面和非共平面多氯聯苯同屬物對於雌性激素於人類乳癌細胞株所誘發不同程度的ROS形成、DNA損害、和細胞毒性皆能產生干擾效應，且雌性激素受體存在與否能影響PCB同屬物調控E2誘發DNA損害作用和細胞毒性。