Accès ouvert
2026
article
OpenAlex
Ruchit Jain, Zouina Sarfraz, Mukesh Kumar Roy, Sabrina Maria Mas et autres
Abstract Background Surgical resection is a standard treatment for large and/or symptomatic newly diagnosed brain metastases (BM). GammaTile brachytherapy delivers immediate intracavitary radiation at surgery and may reduce delay in postoperative treatment. Despite increased usage and adoption, prospective data remain limited. Methods …
us, cz
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Accès ouvert
2026
review
OpenAlex
Ruchit Jain, Namita Ruhela, Khalid Ahmad Qidwai, Fatma Nihan Akkoc Mustafayev et autres
Abstract Background Management of recurrent brain metastases (BM) remains a major clinical challenge, with limited effective salvage options and an increased risk of toxicity with re-irradiation. Intracranial brachytherapy has re-emerged as a focal treatment strategy, enabling localized dose escalation while minimizing exposure …
us
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Accès ouvert
2026
article
OpenAlex
Khalid Ahmad Qidwai, Zouina Sarfraz, Namita Ruhela, Ruchit Jain et autres
Abstract Background Brain metastases are a major cause of morbidity and mortality in EGFR-mutated non-small cell lung cancer (NSCLC). Osimertinib demonstrates central nervous system (CNS) activity, but estimates of intracranial efficacy remain heterogeneous, particularly across treatment lines. Methods PubMed, Cochrane Library, and …
us
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Accès ouvert
2026
review
OpenAlex
Ruchit Jain, Khalid Ahmad Qidwai, Zouina Sarfraz, Fatma Nikan Akkoc Mustafayev et autres
Abstract Background Melanoma brain metastases (MBM) have a well-recognized propensity for hemorrhage, raising concerns regarding the safety of stereotactic radiosurgery (SRS). However, the incidence and prognostic implications of post-SRS hemorrhage remain poorly defined. We performed a systematic review and meta-analysis to quantify …
us
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Accès ouvert
2026
review
OpenAlex
Ruchit Jain, Fatma Nihan Akkoc Mustafayev, Namita Ruhela, Zouina Sarfraz et autres
Abstract Background Radiation necrosis (RN) is a clinically significant toxicity following stereotactic radiosurgery (SRS) for brain metastases, with increasing relevance in the era of multimodal therapy. Although multiple prediction models have been proposed, their performance has not been systematically studied. We performed …
us
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Accès ouvert
2026
article
OpenAlex
Ruchit Jain, Namita Ruhela, Khalid Ahmad Qidwai, Fatma Nihan Akkoc Mustafayev et autres
Abstract Introduction Whole-brain radiation therapy (WBRT) is frequently selected for elderly patients with brain metastases (BM) due to concerns regarding frailty and comorbidity. Stereotactic radiosurgery (SRS) provides effective local control with reduced neurocognitive toxicity. Elderly patients are underrepresented in prospective trials, limiting …
us
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Accès ouvert
2026
review
OpenAlex
Ruchit Jain, Khalid Ahmad Qidwai, Zouina Sarfraz, Namita Ruhela et autres
Abstract Background Optimal management of large brain metastases (BM) remains controversial. While surgery followed by stereotactic radiosurgery (SRS) is commonly used for accessible lesions, SRS alone is increasingly utilized, particularly in patients who are not surgical candidates. We performed a meta-analysis to …
us
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2026
article
OpenAlex
Namita Ruhela, Khalid Ahmad Qidwai, Ruchit Jain, Zouina Sarfraz et autres
e20765 Background: Brain metastases are a major cause of morbidity and mortality in EGFR-mutated non-small cell lung cancer (NSCLC). Osimertinib demonstrates central nervous system (CNS) activity, but intracranial efficacy estimates remain heterogeneous, particularly by treatment line. Methods: Pubmed, Cochrane Library and Scopus …
us
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Accès ouvert
2026
conference-abstract
OpenAlex
Fatma Nihan Akkoc Mustafayev, Zouina Sarfraz, Khalid Ahmad Qidwai, Ruchit Jain et autres
e14031 Background: Brain metastases (BM) are a frequent and clinically significant complication of metastatic breast cancer (BC), often associated with substantial morbidity and poor prognosis. While brain MRI is routinely performed in symptomatic patients, the clinical value of routine MRI screening in …
us
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2026
article
OpenAlex
Fatma Nihan Akkoc Mustafayev, Zouina Sarfraz, Xiaoou Pan, Kevin Vazquez et autres
e14047 Background: Central nervous system (CNS) tumors present unique therapeutic challenges due to limited drug penetration across the blood-brain barrier and the potential for neurologic toxicity. Historically CNS tumors have been underrepresented in early-phase clinical trials (CTs), limiting the data related to …
us
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2026
article
OpenAlex
Ruchit Jain, Namita Ruhela, Khalid Ahmad Qidwai, Fatma Nihan Akkoc Mustafayev et autres
e14017 Background: The role of stereotactic radiosurgery (SRS) is well established in the setting of one to four brain metastases (BM), offering effective control with reduced neurocognitive toxicity compared with whole-brain radiotherapy (WBRT). However, for patients with five or more BM, the …
us
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2026
conference-abstract
OpenAlex
Ruchit Jain, Khalid Ahmad Qidwai, Fatma Nihan Akkoc Mustafayev, Namita Ruhela et autres
e14016 Background: Postoperative stereotactic radiosurgery (SRS) is utilized following resection of brain metastases (BM), however use is limited by target delineation uncertainty and an increased risk of leptomeningeal disease (LMD). Preoperative SRS allows for precise targeting and is being increasingly utilized in …
us
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