An‐Jing Ren

miR ‐221 Mediates the Regulation of Phospholamban Expression and Cardiac Contractility by ZBTB20

Qiu-Xiao Ren, Ya‐Jin Liu, PING H. WANG, Xiaowei Song et autres

AIMS: Phospholamban (PLN) is a key regulator of sarco-endoplasmic reticulum calcium ATPase (SERCA) activity and myocardial contractility, but its expression control remains incompletely understood. This study seeks to clarify the molecular mechanism of PLN regulation and its functional relevance in cardiac physiology. …

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MicroRNA-221: A Context-Dependent Mediator in Human Diseases—Highlights from Molecular Mechanisms to Clinical Translation

Qiu-Xiao Ren, Qian Zhao, Na Wu, Wenfang Du et autres

MicroRNA-221 (miR-221), a conserved small non-coding RNA, acts as a pivotal modulator of biological processes across multiple organ systems, the dysregulation of which is closely linked to the pathogenesis of various human diseases. This review systematically summarizes its multifaceted roles in cancer, …

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MicroRNA-221: A Context-Dependent Mediator in Human Diseases—From Molecular Mechanisms to Clinical Translation

Qiu-Xiao Ren, Qian Zhao, Na Wu, Wenfang Du et autres

MicroRNA-221 (miR-221), a conserved small non-coding RNA, acts as a pivotal modulator of biological processes across multiple organ systems, the dysregulation of which is closely linked to the pathogenesis of various human diseases. This review systematically summarizes its multifaceted roles in cancer, …

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Tailoring V-Mo dual active sites nanozymes-induced oxidative damage of bacteria for anti-infection therapy

Yuhan Sun, Yizhou Yang, Fan Yu Wu, An‐Jing Ren et autres

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ZBTB20 Regulates SERCA2a Activity and Myocardial Contractility Through Phospholamban

An‐Jing Ren, Chunchun Wei, Yajin Liu, Mengna Liu et autres

BACKGROUND: Intracellular Ca 2+ cycling determines myocardial contraction and relaxation in response to physiological demands. SERCA2a (sarcoplasmic/endoplasmic reticulum Ca 2+ -ATPase 2a) is responsible for the sequestration of cytosolic Ca 2+ into intracellular stores during cardiac relaxation, and its activity is reversibly …

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The Role of Prohibitin-2 in Diseases

Fang Liu, You Zhang, Zhiyong Guo, An‐Jing Ren

Prohibitin-2 (PHB2) is a conserved protein in mitochondria that regulates various biological processes, including cell cycle, proliferation, apoptosis, transcription, signal transduction, and mitochondrial ridge morphogenesis. Recently, there has been growing interest in the biological function of PHB2. This article primarily discusses the …

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Eukaryotic Ribosomal Protein S5 of the 40S Subunit: Structure and Function

Lijuan Qiu, Chao Wen, Shan Zhong, An‐Jing Ren

The ribosomal protein RPS5 is one of the prime proteins to combine with RNA and belongs to the conserved ribosomal protein family. It plays a substantial role in the process of translation and also has some non-ribosome functions. Despite the enormous studies …

ChREBP-regulated lipogenesis is not required for the thermogenesis of brown adipose tissue

Chunchun Wei, PING H. WANG, Qi Dong, Xianhua Ma et autres

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The zinc finger and BTB domain containing protein ZBTB20 regulates plasma triglyceride metabolism by repressing lipoprotein lipase gene transcription in hepatocytes

Hao Li, Gan Liu, Xiaoqing Wan, Luting Zhou et autres

BACKGROUND AND AIMS: Lipoprotein lipase (LPL) is responsible for the lipolytic processing of triglyceride-rich lipoproteins, the deficiency of which causes severe hypertriglyceridemia. Liver LPL expression is high in suckling rodents but relatively low at adulthood. However, the regulatory mechanism and functional significance …

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ZBTB20 in Nociceptive Neurons of the Trigeminal Ganglia Regulates Pruritus

Xin Jia, Menghan Dai, An‐Jing Ren, Tingting Wang et autres

Recent studies have shown that ZBTB20, a zinc-finger protein containing transcription factor, is highly expressed in small-diameter primary sensory neurons in mice, and modulates pain through regulating TRP channels. However, whether ZBTB20 regulates itch sensation has not been demonstrated. In this study, …

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Zbtb20 deficiency causes cardiac contractile dysfunction in mice

An‐Jing Ren, Chao Chen, Sha Zhang, Mengna Liu et autres

The zinc-finger protein ZBTB20 regulates development and metabolism in multiple systems, and is essential for postnatal survival in mice. However, its potential role in the cardiovascular system remains undefined. Here, we demonstrate that ZBTB20 is critically involved in the regulation of cardiac …

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ZBTB20 regulates EGFR expression and hepatocyte proliferation in mouse liver regeneration

Hai Zhang, Jianhui Shi, Hui Jiang, Kejia Wang et autres

Liver has a unique regenerative capacity, however, its regulatory mechanism is not fully defined. We have established the zinc-finger protein ZBTB20 as a key transcriptional repressor for alpha-fetoprotein (AFP) gene in liver. As a marker of hepatic differentiation, AFP expression is closely …

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