Yingying Luo

Clinical and radiological characteristics of adult-onset X-linked adrenoleukodystrophy: a Chinese cohort study and review of the literature

Xiao Han, Hui Huang, Ying Qing Chen, Yingying Luo et autres

BACKGROUND: Adrenoleukodystrophy (ALD) is a rare X-linked genetic metabolic disorder characterized by the accumulation of very long chain fatty acids (VLCFA) within the adrenal glands, as well as the central and peripheral nervous systems. Adult-onset ALD is particularly uncommon and easily misdiagnosed. …

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Mutations in the spliceosomal gene SNW1 cause neurodevelopment disorders with microcephaly

Lei Ji, Yan Jin, Nicole A. Losurdo, Hua Wang et autres

The spliceosome is a critical cellular machinery responsible for pre-mRNA splicing that is essential for the proper expression of genes. Mutations in its core components are increasingly linked to neurodevelopmental disorders, such as primary microcephaly. Here, we investigated the role of SNW …

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Long non-coding RNA AK007111 mediates mast cells apoptosis via targeting of protein MOAP1

Xiao Ma, Yingying Luo, Jiejing Xu, Feng Liu et autres

BACKGROUND: Long non-coding RNAs (lncRNAs) are emerging regulators of pathophysiological processes in a variety of diseases including asthma. In this study, we reported the identification of lncRNA-AK007111 as an essential modulator of mast cell apoptosis and investigated its potential mechanism. METHODS: RNA-seq …

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Cubebin alleviates chronic stress-induced depression-like behavior in mice by regulating the gut microbiome

Mengyun Wan, Wei Wang, Mingzhen He, Shilin Yang et autres

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Synthesis, characterization, crystal structures and biological activity of 4-chloro-2-(2-hydroxy-3-ethoxybenzylideneamino)phenol and complexes

Zhengwei Wu, Jiawen Bao, Hongyang Zhang, Wanlin Wei et autres

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Immune response plays a role in Mycoplasma pneumoniae pneumonia

Yifan Zhu, Yingying Luo, Ling Li, Xinyi Jiang et autres

Introduction: Mycoplasma pneumoniae (MP) is a major pathogen of community-acquired pneumonia in children. However, the specific pathogenesis of the progression of Mycoplasma pneumoniae pneumonia (MPP) is unclear. We aimed to reveal the landscape of microbiota and the host immune response in MPP. …

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Myasthenia gravis coexisting with HINT1-related motor axonal neuropathy without neuromyotonia: a case report

Jia Fang, Hui Huang, Qiang Lei, Yingying Luo et autres

BACKGROUND: HINT1 mutations cause an autosomal recessive axonal neuropathy with neuromyotonia. This is a first case report of coexistence of myasthenia gravis (MG) and HINT1-related motor axonal neuropathy without neuromyotonia. CASE PRESENTATION: A 32-year-old woman presented with recurrent ptosis for 8 years, …

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Syntheses, crystal structures, and antimicrobial activities of tetranuclear Ni4 and Ni2Zn2 complexes derived from tetradentate Schiff bases

Jie Zhao, Jing Ji, Shi‐Yi Wang, Yingying Luo et autres

Two new homo-tetranuclear nickel(II) complexes, [Ni4(L1)4(CH3OH)4] (1) and [Ni4(L2)4(CH3OH)4] (2), and two new hetero-tetranuclear nickel(II)-zinc(II) complexes, [Ni2Zn2I2(L1)2(μ1,1-N3)2]CH3OH (3) and [Ni2Zn2Cl2(L2)2(μ1,1-N3)2]H2O (4), where L1is the deprotonated form of 4-tert-butyl-2-(3-ethoxy-2-hydroxybenzylideneamino)phenol (HL1) and L2 is the deprotonated form of 4-tert-butyl-2-(2-hydroxy-3-methoxybenzylideneamino)phenol (HL2), have been synthesized. Structures …

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Clinical Presentations and Genetic Characteristics of Late-Onset MADD Due to ETFDH Mutations in Five Patients: A Case Series

Zhenchu Tang, Shan Gao, Miao He, Qihua Chen et autres

Background: Late-onset multiple acyl-CoA dehydrogenase deficiency (LO-MADD) describes a curable autosomal recessive genetic disease caused by ETFDH mutations that result in defects in ETF-ubiquinone oxidoreductase. Almost all patients are responsive to riboflavin. This study describes the clinical presentations and genetic characteristics of …

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Synthesis, crystal structure, and urease inhibition of an end-on azido-bridged dinuclear copper(II) complex with an oxidized tridentate Schiff base ligand

Jiaqi Wang, Yingying Luo, Yixuan Zhang, Yue Chen et autres

An end-on azido-bridged dinuclear copper(II) complex, [Cu2L2(μ1,1-N3)2], where L is the deprotonated form of N-(2-hydroxy-4-methoxybenzylidene)picolinamide (HL), has been prepared by the reaction of 5-methoxy-2-[(pyridin-2-ylmethylimino)methyl]phenol (HL′) with copper bromide and sodium azide in methanol. The structure of the complex was characterized by elemental …

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Syntheses, characterization and crystal structures of fluorine substituted Schiff base copper(II) and nickel(II) complexes with biological activity

Yingying Luo, Jiaqi Wang, Bitong Zhang, Yixing Guan et autres

Two copper(II) complexes, [Cu2(L1)2]·2H2O (1) and [Cu3(L1)2(NCS)2] (2), and two nickel(II) complexes, [NiL2(NCS)] (3) and [Ni(L2)2(NCS)]·CH3OH (4), were prepared from the fluorine substituted Schiff bases N,N'-bis(4-fluorosalicylidene)-1,2-diaminopropane (H2L1) and 4-fluoro-2-[(2-isopropylaminoethylimino)methyl]phenol (HL2), respectively. The compounds were characterized by physico-chemical methods. Structures of the complexes …

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Association between KIF1B rs17401966 genetic polymorphism and hepatocellular carcinoma susceptibility: an updated meta-analysis

Yingying Luo, Hongpeng Zhang, Ailong Huang, Jieli Hu

BACKGROUND: Several studies have focused on the association between KIF1B rs17401966 polymorphism and susceptibility to hepatitis B virus-related (HBV-related) hepatocellular carcinoma (HCC), but the conclusions have been inconsistent. We have conducted this updated meta-analysis to explore the association between KIF1B rs17401966 polymorphism …

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