Xiao Zhang

DGOU classification guided cement diffusion strategy in unilateral kyphoplasty for osteoporotic vertebral compression fractures

Donghui Cao, Xusheng Li, Wenbo Gu, Yu Yang et autres

The optimal cement diffusion pattern in unilateral percutaneous kyphoplasty (PKP) for osteoporotic vertebral compression fractures (OVCFs) remains debated. This multicenter retrospective study investigated whether crossing the vertebral midline with bone cement is necessary under the DGOU classification. A total of 440 patients …

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Cryogenic volume electron microscopy of whole plant protoplasts

Xiao Zhang, Zihan Lin, Jake Kaminsky, Liguo Wang et autres

Abstract Volume electron microscopy (vEM) provides nanometer-scale, three-dimensional imaging of cells, but applying it to plant systems remains challenging. Cell walls, large vacuoles, and tissue thickness complicate sample preparation and cryogenic imaging. Here we report a cryogenic vEM (cryo-vEM) workflow for unstained …

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NRF2 Pathway Activation as a Molecular Toxicology Mechanism in Oxidative Stress and Lipid Metabolic Disorders

Muhammad Arif Asghar, Lie Yuan, Yazhen Zhang, Shixin Tang et autres

Lipid metabolic disorders, driven by oxidative stress, lipid peroxidation, and chronic inflammation, are key contributors to toxicological damage underlying Nonalcoholic fatty liver disease (NAFLD), atherosclerosis, and metabolic syndrome. The nuclear factor erythroid 2-related factor 2 (NRF2) pathway, a master regulator of antioxidant …

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Functional characterization of a plant terpene synthase in the Conogethes punctiferalis: A novel role in the developmental regulation

Xuan Song, Jun‐Feng Kou, Chaoqun Yi, Xiao Zhang et autres

• Plant-derived terpene synthase regulates YPM development, validating CpuTPS structure-function. • β-Bisabolene bidirectionally inhibits a metabolic pathway, causing stage-specific blockade. • Transcriptome-Microbiome integration reveals host-microbe dynamic crosstalk mechanism. • Molecular and microbial responses differ between 3 rd and 5 th instars, demonstrating …

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Prevalence and characteristics of metabolic dysfunction-associated steatohepatitis among pediatric patients in the MarketScan Databases

Gail F. Fernandes, Tongtong Wang, Samuel S. Engel, Xinyue Liu et autres

Introduction There are few epidemiologic studies of the prevalence of metabolic dysfunction-associated steatohepatitis (MASH) among pediatric populations.ObjectiveTo estimate the cross-sectional prevalence of MASH in the pediatric (<18 years) populations of MerativeTM MarketScan® Commercial Database (Commercial) and MerativeTM MarketScan® Multi-State Medicaid Database (Medicaid). …

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Prevalence and characteristics of metabolic dysfunction-associated steatohepatitis among pediatric patients in the MarketScan Databases

Kennedy M. Peter‐Marske, Xiao Zhang, Tongtong Wang, Xinyue Liu et autres

INTRODUCTION: There are few epidemiologic studies of the prevalence of metabolic dysfunction-associated steatohepatitis (MASH) among pediatric populations. OBJECTIVE: To estimate the cross-sectional prevalence of MASH in the pediatric (<18 years) populations of MerativeTM MarketScan® Commercial Database (Commercial) and MerativeTM MarketScan® Multi-State Medicaid …

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A pathological role of O-GlcNAcylation-driven TR11B production and function in lung adenocarcinoma

Shiyu Qiu, Lifang Ma, Keke Yu, Xin Xu et autres

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SwinCell: a 3D transformer and flow-based framework for improved cell segmentation

Xiao Zhang, Zihan Lin, Liguo Wang, Yong S. Chu et autres

Segmentation of three-dimensional (3D) cellular images is fundamental for studying and understanding cell structure and function. However, 3D cellular segmentation is challenging, particularly for dense cells and tissues. This challenge arises mainly from the complex contextual information within 3D images, anisotropic properties, …

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Manipulation of glycine–serine and flavanone metabolism to maintain plasma membrane stability and improve drought tolerance of millet

Mengjiao Wang, Bianyin Wang, Yajie Liu, Xiao Zhang et autres

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[Comparison of biomechanical effects and tissue reparability of photodynamic and laser in the adjuvant treatment of peri-implantitis].

Xiao Zhang, Hui Yang

PURPOSE: To compare the biomechanical effects and tissue reparability of photodynamic and laser in the adjuvant treatment of peri-implantitis. METHODS: A total of 112 patients with peri-implantitis who were diagnosed and treated from March 2023 to April 2024 were randomly divided into …

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ZBED6 deficiency enhances porcine carcass traits and meat quality via ISLR-mediated Wnt signaling activation

Huan Liu, Jiahe Huang, Junying Xiao, Ruixin Zhang et autres

• ZBED6 deficiency improves growth performance and meat quality of pigs. • ZBED6 deficiency increases the content of n-3PUFA, EAA and FAA in LD muscle. • ISLR is a ZBED6-IGF2-independent and evolutionarily conserved direct target of ZBED6. • ZBED6 deficiency promotes skeletal …

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Preclinical Characterization of Efficacy and Pharmacodynamic Properties of Finotonlimab, a Humanized Anti-PD-1 Monoclonal Antibody

Yunqi Yao, Xiaoning Yang, Jing Li, Erhong Guo et autres

Background/Objectives: Finotonlimab (SCTI10A) is a humanized anti-PD-1 antibody tested in Phase III trials for several solid tumor types. Methods: This study characterized the in vitro and in vivo efficacy, Fc-mediated effector function, and non-clinical PK/PD properties of finotonlimab. Results: The results demonstrated …

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