Chenxi Zhao

Crt-miR166a, a Citrus-Derived MicroRNA, Modulates the Gut Microbiota-Metabolites under High-Fat Diet

Minmin Zhan, Chenxi Zhao, Bin Chen, Yanhui Han et autres

High-fat diet (HFD) induces dysregulation of gut microbiota-derived metabolites, including short-chain fatty acids, bile acids, and indole derivatives. Although microRNAs (miRNAs) are known to regulate gut microbiota composition, the effects of plant miRNAs on microbiota-derived metabolite outcomes remain poorly understood. This study …

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The Impact of Apple Pectin on Gut Microbiota and Bile Acid Homeostasis in mice treated with an alternating Low-Fat/High-Fat Diet

Chenxi Zhao, Minmin Zhan, Hengjun Du, Kai Zhu et autres

Dietary components play a critical role in modulating gut microbiota composition. Pectin has a positive regulatory effect on the disorder of gut microbiota-metabolites caused by a high-fat diet. A cyclic low-fat/high-fat diet (CLHFD), the alternating cycle between short-term low-fat and high-fat diets …

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Citrus-Derived Exosome-like Nanoparticles Attenuate High-Fat Diet-Aggravated Colitis by Gut Microbiota-Metabolites Modulation

Minmin Zhan, Chenxi Zhao, Yanhui Han, Bin Chen et autres

High-fat diet (HFD) is a recognized risk factor that exacerbates intestinal inflammation and complicates colitis pathology, posing challenges for treatment. This study evaluated citrus-derived exosome-like nanoparticles (CELNs) as a dietary intervention. Results demonstrated that CELNs effectively ameliorated HFD-aggravated colitis, improving the disease …

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Transcriptomic and Metabolomic Responses to Growth Differences in Litopenaeus vannamei Infected with Enterocytozoon hepatopenaei

Shanshan Li, Yong Wu, Jiaqi Jin, Bo Wu et autres

Litopenaeus vannamei, a widely cultivated aquatic species worldwide, has its growth status intrinsically tied to the economic profitability of the aquaculture industry. However, infection by the microspondian parasite Enterocytozoon hepatopenaei (EHP) has emerged as a pivotal threat to the healthy growth of …

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Impact of Citrus Pectin on Gut Microbiota Metabolism Dysbiosis Induced by Transient Alternating High-Fat Diet

Chenxi Zhao, Minmin Zhan, Hengjun Du, Kai Zhu et autres

Pectin, as an important component of dietary fiber, plays a crucial regulatory role in maintaining the homeostasis of gut microbiota. The transient alternate high-fat diet (TAHD) is a dietary pattern that alternates between 3 days of a low-fat diet (LFD) and 3 …

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ADNP-15: An Open-Source Histopathological Dataset for Neuritic Plaque Segmentation in Human Brain Whole Slide Images with Frequency Domain Image Enhancement for Stain Normalization

Chenxi Zhao, Jianqiang Li, Qing Zhao, Jing Bai et autres

Alzheimer's Disease (AD) is a neurodegenerative disorder characterized by amyloid-beta plaques and tau neurofibrillary tangles, which serve as key histopathological features. The identification and segmentation of these lesions are crucial for understanding AD progression but remain challenging due to the lack of …

GPX4 activator enhances neuroprotection and functional recovery in spinal cord injury

Xinjie Liu, Yilin Pang, Baoyou Fan, Jiawei Zhang et autres

Background Spinal cord injury (SCI) exerts severe physical, social, and economic effects on individuals and the healthcare system. While much progress has been made in understanding the pathophysiology of SCI, the regulation of the ferroptosis master regulator, GPX4 (Glutathione Peroxidase 4), remains …

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Modelling lined rock caverns subject to hydrogen embrittlement and cyclic pressurisation in fractured rock masses

Chenxi Zhao, Haiyang Yu, Zixin Zhang, Qinghua Lei

The technology of lined rock cavern (LRC) with great geographical flexibility is a promising, cost-effective solution to underground hydrogen storage. However, the air-tight steel tanks used in this technology are susceptible to material degradation due to hydrogen embrittlement (HE), potentially leading to …

Recombinase Polymerase Amplification and Target-Triggered CRISPR/Cas12a Assay for Sensitive and Selective Hepatitis B Virus DNA Analysis Based on Lanthanide Tagging and Inductively Coupled Plasma Mass Spectrometric Detection

Chenxi Zhao, Lijie Du, Jing Hu, Xiandeng Hou

Herein, we report a target-triggered CRISPR/Cas12a assay by coupling lanthanide tagging and inductively coupled plasma mass spectrometry (ICP-MS) for highly sensitive elemental detection. Hepatitis B virus (HBV) DNA was chosen as a model analyte, and recombinase polymerase amplification (RPA) was used for …

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YHP: Y-chromosome Haplogroup Predictor for predicting male lineages based on Y-STRs

Mengyuan Song, Chenxi Zhao, Feng Song, Yiping Hou

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The rise of baobab trees in Madagascar

Jun‐Nan Wan, Shengwei Wang, Andrew R. Leitch, Ilia J. Leitch et autres

Abstract The baobab trees (genus Adansonia ) have attracted tremendous attention because of their striking shape and distinctive relationships with fauna 1 . These spectacular trees have also influenced human culture, inspiring innumerable arts, folklore and traditions. Here we sequenced genomes of …

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Gonadal transcriptome sequencing reveals sexual dimorphism in expression profiling of sex-related genes in Asian arowana (Scleropages formosus)

Chenxi Zhao, Chao Bian, Xidong Mu, Xinhui Zhang et autres

Asia arowana (Scleropages formosus) is an ornamental fish with high economic value, while its sex determination mechanism is still poorly understood. By far, no morphological evidence or molecular marker has been developed for effective distinguishment of genders, which poses a critical challenge …

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