Shoaib Khan

Tailored pyrrole-based imidazothiazole scaffolds: Synthetic elaboration, enzyme kinetic profiling and DFT-guided molecular docking toward Antidiabetic therapeutics

Zanib Fiaz, Shoaib Khan, Tayyiaba Iqbal, Wajid Rehman et autres

pk, cn, uz, sa (code pays fourni par la source)

Potent cholinesterase inhibitors for alzheimer’s disease: synthesis, biological evaluation and computational analysis of novel oxadiazole analogues

Aiman Bibi, Muhammad Shahid Nadeem, Bibi Nazia Murtaza, Saima Iftikhar et autres

pk, sa (code pays fourni par la source)

From concept to simulations: computational and experimental assessment of thiadiazole–thiazolidinone hybrid chalcones for anti-alzheimer potentials

Muhammad Bilal Khan, Shoaib Khan, Tayyiaba Iqbal, Sampath Chinnam et autres

pk, in, sa, uz (code pays fourni par la source)

Synthesis, SAR, and computational evaluation of novel thiazolidinone-based antidiabetic hybrids: insights from enzyme kinetics and DFT studies

Abdul Hafeez, Shoaib Khan, Tayyiaba Iqbal, Eman Alzahrani et autres

pk, sa (code pays fourni par la source)

Synthesis‐Oriented Molecular Frameworks of Novel Pyrimidine–Thiadiazole Derivatives: Kinetic Behavior, Binding Mechanism, and Pharmacological Investigations Targeting Alzheimer's Disease

Shoaib Khan, Tayyiaba Iqbal, Bibi Zunaira, Bibi Nazia Murtaza et autres

Abstract The present study focuses on synthesis of pyrimidine derived thiadiazole based Schiff base derivatives (1–10), as effective inhibitors against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) for treatment of Alzheimer's disease. Among these analogs, strong inhibition was shown by analog 8 with IC …

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Synthesis, in vitro and kinetic study of thiazolidinone derivatives: insight from a network medicinal approach for thymidine phosphorylase and alpha glucosidase

Shoaib Khan, Tayyiaba Iqbal, Sampath Chinnam, Eman Alzahrani et autres

AIMS: This study aimed to design, synthesize, and evaluate a novel series of pyridine-linked thiazolidinone analogues (1-15) as dual inhibitors of thymidine phosphorylase and α-glucosidase, with potential therapeutic applications in diabetes mellitus and cancer-related angiogenesis. MATERIALS & METHODS: The compounds were synthesized …

pk, in, sa, bd, kr (code pays fourni par la source)

Novel oxazole derivatives as anti-diabetic agents along with in silico modeling: a critical analysis of recent trends and finding

Shoaib Khan, Tayyiaba Iqbal, Wajid Rehman, Mujaddad Ur Rehman et autres

pk, sa (code pays fourni par la source)

Thiazole–Thiadiazole Compounds for Enzymatic Modulation and Therapeutic Targeting in Diabetes Mellitus

Shoaib Khan, Tayyiaba Iqbal, Sobhi M. Gomha, Magdi E. A. Zaki et autres

ABSTRACT One of the most significant problems facing the scientific community in the 21st century is diabetes mellitus. There is an urgent need to create new powerful compounds that can fight this terrible disease because the number of instances of diabetes and …

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Designing oxazole-linked sulfonamides with optimal structural features for enhanced antidiabetic efficacy: A quantitative approach

Shoaib Khan, Tayyiaba Iqbal, Rafaqat Hussain, Hamdy Kashtoh et autres

A series of novel 14 oxazole based sulfonamide derivatives were synthesized via a multistep process which involves the linkage of substituted oxazole moiety and sulfonamide group. The structures of these compounds were elucidated using HREI-MS, 13 CNMR and 1 HNMR techniques. The …

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Computationally Driven Exploration of Novel bis‐Thiadiazole Sulfonamides as Alzheimer's Enzyme Inhibitors: A DFT and Kinetic Perspective

Farman Ullah, Shoaib Khan, Tayyiaba Iqbal, Hamdy Kashtoh et autres

ABSTRACT In this research work, bis‐thiadiazole based sulfonamide hybrid analogues (1–15) were synthesized by a novel synthetic approach. Structural confirmation was accomplished through 1HNMR, 13CNMR, and HREI‐MS techniques. Further, these analogues were examined for their biological activities against AChE and BuChE (Alzheimer …

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Synthesis of chitosan-polyethylene glycol-based superabsorbent for enhanced water retention in agriculture

Mohsan Nawaz, Mesha Saeed, Muhammad Zahoor, Saira Bibi et autres

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Computationally guided design and synthesis of pyrimidine–oxazole hybrids as novel antidiabetic agents: kinetic and molecular interaction studies

Shoaib Khan, Tayyiaba Iqbal, Faez Falah Alshehri, Zafer Saad Al Shehri et autres

pk, sa, kr (code pays fourni par la source)