Antonio Domenico Procopio

Implementing Multimodal Liquid Biopsy in Glioblastoma: A Prospective Feasibility Study of a Standardized Clinical Workflow

Mario Chiapponi, Fabiola Cappella, Laura Andreacchio, Ruggero Antonini¹ et autres

Background: Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults, characterized by poor prognosis and limited treatment options. Liquid biopsy offers a minimally invasive approach for molecular profiling and disease monitoring, potentially overcoming tissue sampling and neuroimaging limitations. …

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Differential Impact of Olive Leaf Extract and Its Secoiridoid Components, Oleuropein Aglycone and Oleacin, on Adipogenic Differentiation and Proliferation of Bone Marrow Mesenchymal Stem Cells

Chiara Giordani, Angelica Giuliani, Silvia Di Valerio, Tatiana Spadoni et autres

Background/Objectives: Bone marrow adipose tissue (BMAT) serves multiple physiological roles but accumulates with age, compromising skeletal health. This expansion is largely driven by an adipogenic drift of bone marrow mesenchymal stromal cells (BMSCs), shifting attention toward stromal cell fate regulation as a …

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Additional file 1 of Association of an inflammaging score based on IL-6, IL-10 and CXCL9, and frailty with long-term mortality in hospitalized older adults

Matilde Sbriscia, Sonia Fantone, Mirko Di Rosa, Francesca Marchegiani et autres

Supplementary Material 1.

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Additional file 1 of Association of an inflammaging score based on IL-6, IL-10 and CXCL9, and frailty with long-term mortality in hospitalized older adults

Matilde Sbriscia, Sonia Fantone, Mirko Di Rosa, Francesca Marchegiani et autres

Supplementary Material 1.

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Association of an inflammaging score based on IL-6, IL-10 and CXCL9, and frailty with long-term mortality in hospitalized older adults

Matilde Sbriscia, Sonia Fantone, Mirko Di Rosa, Francesca Marchegiani et autres

Abstract Background Aging is accompanied by chronic low-grade inflammation ("inflammaging"), which contributes to increased morbidity and mortality in older adults. This study evaluated the prognostic value of circulating inflammatory biomarkers, i.e. interleukin-6 (IL-6), interleukin-10 (IL-10), and CXCL9, and their integration with frailty …

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Association of an inflammaging score based on IL-6, IL-10 and CXCL9, and frailty with long-term mortality in hospitalized older adults

Matilde Sbriscia, Sonia Fantone, Mirko Di Rosa, Francesca Marchegiani et autres

Abstract Background Aging is accompanied by chronic low-grade inflammation ("inflammaging"), which contributes to increased morbidity and mortality in older adults. This study evaluated the prognostic value of circulating inflammatory biomarkers, i.e. interleukin-6 (IL-6), interleukin-10 (IL-10), and CXCL9, and their integration with frailty …

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DNA Methylation-derived biological age and long-term mortality risk in subjects with type 2 diabetes

Jacopo Sabbatinelli, Angelica Giuliani, Katarzyna Malgorzata Kwiatkowska, Giulia Matacchione et autres

BACKGROUND: Individuals with type 2 diabetes (T2D) face an increased mortality risk, not fully captured by canonical risk factors. Biological age estimation through DNA methylation (DNAm), i.e. the epigenetic clocks, is emerging as a possible tool to improve risk stratification for multiple …

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Decreased serum levels of inflammaging marker miR-146a are associated with clinical response to tocilizumab in COVID-19 patients

Jacopo Sabbatinelli, Angelica Giuliani, Giulia Matacchione, Silvia Latini et autres

ABSTRACT Background Current COVID-19 pandemic poses an unprecedented threat to global health and healthcare systems. At least in western countries, the most amount of the death toll is accounted by old people affected by age-related diseases. In this regard, we proposed that …

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DIAGNOSI DELLE INFEZIONI DA CLAMIDIE

Alessandra Felici, Antonio Domenico Procopio, Roberto Rambaldi, Valerio Tozzi

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