David R. Price

Association between thrombocytopenia and development of acute respiratory distress syndrome

Elpida Charalampaki, Konstantinos Gkirgkiris, David R. Price, Eleni Papoutsi et autres

BACKGROUND: Given that platelets support the integrity of the alveolar-capillary membrane, it is conceivable that thrombocytopenia may be associated with development of acute respiratory distress syndrome (ARDS). Yet, clinical studies confirming such an association are limited. We endeavoured to examine whether thrombocytopenia …

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Early Mortality in Clinical Trials of Acute Respiratory Distress Syndrome

Vassilis G. Giannakoulis, Edward James Schenck, Eleni Papoutsi, David R. Price et autres

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A Razor's Edge: Vascular Responses to Acute Inflammatory Lung Injury/Acute Respiratory Distress Syndrome

David R. Price, Joe G. N. Garcia

Historically considered a metabolically inert cellular layer separating the blood from the underlying tissue, the endothelium is now recognized as a highly dynamic, metabolically active tissue that is critical to organ homeostasis. Under homeostatic conditions, lung endothelial cells (ECs) in healthy subjects …

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Epigenetic memory of coronavirus infection in innate immune cells and their progenitors

Jin‐Gyu Cheong, Arjun Ravishankar, Siddhartha Sharma, Christopher N. Parkhurst et autres

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Auto-immunoproteomics analysis of COVID-19 ICU patients revealed increased levels of autoantibodies related to the male reproductive system

Frank Schmidt, Houari Abdesselem, Karsten Suhre, Nishant N. Vaikath et autres

Background: Coronavirus disease (COVID-19) manifests many clinical symptoms, including an exacerbated immune response and cytokine storm. Autoantibodies in COVID-19 may have severe prodromal effects that are poorly understood. The interaction between these autoantibodies and self-antigens can result in systemic inflammation and organ …

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Mitochondria in health, disease, and aging

John S. Harrington, Stefan W. Ryter, Maria E. Plataki, David R. Price et autres

Mitochondria are well known as organelles responsible for the maintenance of cellular bioenergetics through the production of ATP. Although oxidative phosphorylation may be their most important function, mitochondria are also integral for the synthesis of metabolic precursors, calcium regulation, the production of …

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Authors' Reply

David R. Price, Elisa Benedetti, Jan Krumsiek

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Angiopoietin 2 Is Associated with Vascular Necroptosis Induction in Coronavirus Disease 2019 Acute Respiratory Distress Syndrome

David R. Price, Elisa Benedetti, Luis G. Gómez-Escobar, Sergio L. Alvarez-Mulett et autres

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Auto-Immunoproteomics Analysis of COVID-19 ICU Patients Revealed Increased Levels of Autoantibodies Related to Male Reproductive System

Frank Schmidt, Houari Abdesselem, Karsten Suhre, Muhammad Umar Sohail et autres

Abstract The role of autoantibodies in coronavirus disease (COVID-19) complications is not yet fully understood. The current investigation screened two independent cohorts of 97 COVID-19 patients (Discovery (Disc) cohort from Qatar (n = 49) and Replication (Rep) cohort from New York (n …

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Identifying organ dysfunction trajectory-based subphenotypes in critically ill patients with COVID-19

Chang Su, Zhenxing Xu, Parag Goyal, Monika M. Safford et autres

COVID-19-associated respiratory failure offers the unprecedented opportunity to evaluate the differential host response to a uniform pathogenic insult. Understanding whether there are distinct subphenotypes of severe COVID-19 may offer insight into its pathophysiology. Sequential Organ Failure Assessment (SOFA) score is an objective …

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The maladaptive vascular response in COVID-19 acute respiratory distress syndrome and recovery

David R. Price, Elisa Benedetti, Luis G. Gómez-Escobar, Sergio L. Alvarez-Mulett et autres

ABSTRACT Vascular injury is a menacing element of acute respiratory distress syndrome (ARDS) pathogenesis. To better understand the role of vascular injury in COVID-19 ARDS, we used lung autopsy immunohistochemistry and blood proteomics from COVID-19 subjects at distinct timepoints in disease pathogenesis, …

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Attributable mortality of acute respiratory distress syndrome: a systematic review, meta-analysis and survival analysis using targeted minimum loss-based estimation

Lisa K. Torres, Clara Oromendia, Ivan Matos Diaz, John S. Harrington et autres

BACKGROUND: Although acute respiratory distress syndrome (ARDS) is associated with high mortality, its direct causal link with death is unclear. Clarifying this link is important to justify costly research on prevention of ARDS. OBJECTIVE: To estimate the attributable mortality, if any, of …

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