João Miguel De Frias

Editorial: Case reports in veterinary neurology and neurosurgery, volume II

Koen M. Santifort, João Miguel De Frias, Simone Spinillo, Bruno A. Lopes et autres

In their publication titled 'Case Report: Feline spinous process giant-cell osteosarcoma', Vercoutere et al. reported two cases of vertebral giant cell osteosarcoma in cats with progressive myelopathy with clinical findings, diagnostic imaging, surgery, follow-up and histopathology. This differential diagnosis is important to …

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Phenotypic features of paroxysmal dyskinesia in Dachshund dogs: 62 cases (2017-2025)

Bethany Boyd, Giulia Corsini, Dakir N. Polidoro, Sofie F. M. Bhatti et autres

BACKGROUND: Paroxysmal dyskinesia (PxD) has not been characterized in Dachshunds. HYPOTHESIS/OBJECTIVES: Describe the phenotype, treatment, and outcome of PxD in Dachshunds. ANIMALS: Sixty-two Dachshunds with presumptive PxD. METHODS: Observational, retrospective, multicenter study of dogs diagnosed with PxD between 2017 and 2025, with …

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Spinal arachnoid diverticula and constrictive myelopathy in dogs: different conditions or a spectrum of spinal meningeal disease in veterinary and human medicine?

João Miguel De Frias, Sadaquate Khan, Cecilia Rohdin, Sofie F. M. Bhatti et autres

Different conditions affecting the spinal meningeal layers have been reported in human and veterinary medicine. In veterinary medicine, two separate conditions have been reported. Spinal arachnoid diverticula (SAD) have been well documented for decades, while constrictive myelopathy (CM) in pugs was identified …

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A novel hereditary encephalopathy in four related Labrador Retrievers associated with a missense variant in the ALDH5A1 gene

Ellen Schofield, Thomas Patrick Butler, Rita Gonçalves, Louise Pettitt et autres

BACKGROUND: Hereditary neurodegenerative diseases occur in dogs, and a molecular diagnosis can be of value for treatment and prevention. HYPOTHESIS/OBJECTIVES: To describe the clinical presentation of a novel encephalopathy in 4 related Labrador Retrievers. To identify a candidate causal variant for the …

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An update on spinal arachnoid diverticula in dogs and cats

João Miguel De Frias, Sofie F. M. Bhatti, Steven De Decker

Spinal arachnoid diverticula (SAD) are an uncommon neurological condition in dogs and rare in cats. SAD is characterized by a focal subarachnoid dilation that causes compression on the spinal cord. The clinical presentation in dogs and cats is similar, with non-painful, generally …

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Computed tomographic features of pituitary apoplexy in a cat

Will Howard Swan, M. Taylor, Ivona Orgonikova, João Miguel De Frias

An 11-year-old, female neutered domestic long hair cat was presented, following a peracute onset of agitation, ataxia, and vocalisation progressing over three days to obtundation. Neurological examination showed severe obtundation, ambulatory tetraparesis, and compulsive circling to the left. Postural reactions were decreased …

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Author response for "Amyloid-Beta Pathology Increases Synaptic Engulfment by Glia in Feline Cognitive Dysfunction Syndrome: A Naturally Occurring Model of Alzheimer's Disease"

Robert I. McGeachan, Lucy Ewbank, Lorena Sordo, Alexandra J. Malbon et autres

Author response for "Amyloid-Beta Pathology Increases Synaptic Engulfment by Glia in Feline Cognitive Dysfunction Syndrome: A Naturally Occurring Model of Alzheimer's Disease"

Robert I. McGeachan, Lucy Ewbank, Lorena Sordo, Alexandra J. Malbon et autres

Amyloid-beta pathology increases synaptic engulfment by glia in feline cognitive dysfunction syndrome: A naturally occurring model of Alzheimer’s disease

Robert I. McGeachan, Lucy Ewbank, Lorena Sordo, Alexandra J. Malbon et autres

Abstract Feline cognitive dysfunction syndrome (CDS) is an age-related neurodegenerative disorder, comparable to dementia in people, characterised by behavioural changes such as increased vocalisation, altered social interactions, sleep-wake cycle, disorientation and house-soiling. Although the underlying mechanisms remain poorly understood, pathologies similar to …

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Spinal arachnoid diverticula in cats: Clinical presentation, diagnostic imaging findings, treatment, and outcome

João Miguel De Frias, Sofie F. M. Bhatti, George Nye, Rita Gonçalves et autres

BACKGROUND: Spinal arachnoid diverticulum (SAD) is considered a rare disease in cats. Previous reports mainly classified SAD in cats as acquired. HYPOTHESIS/OBJECTIVES: The aim of this study was to describe the signalment, clinical presentation, diagnostic imaging findings, and outcome in a group …

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Description and clinical relevance of the variable conformation of canine spinal arachnoid diverticula

João Miguel De Frias, Steven De Decker, Alberta De Stefani, Francisco Llabrés‐Díaz

The conformation of spinal arachnoid diverticula (SAD) and their clinical implications are poorly characterized in dogs. This retrospective cross-sectional study describes different SAD conformations in dogs and aims to identify if there is an association between SAD conformation and clinical features, localization, …

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Ethical problems arising from the use of placebo in clinical trials with drugs for migraine. Their analysis by the moral deliberation method

João Miguel De Frias, Julio Pascual, Juan José Lahuerta, Daniel de la Iglesia Gracía et autres

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