Hongmei Sun

CYCLING DOF FACTOR 2 functions as a positive regulator integrating gibberellin signaling and biosynthesis to drive bulb germination in Lilium

Xiaoman Zou, Hui Zhou, Shengli Song, Hongmei Sun

The dormancy release and initiation of germination in underground storage organs are critical for plant adaptation and agriculture. Gibberellin (GA) promotes germination, but how GA signaling achieves self-amplification at the early stage of germination to drive rapid germination remains unknown. In particular, …

cn, Nigéria (code pays fourni par la source)

HPγCD as a molecular chaperone empowers celastrol: Polymer-free nanofibers combat drug-resistant bacteria

Jiangtao Su, Jiahao Liang, 甘亚倩, Yi Guo et autres

cn (code pays fourni par la source)

MaCDSP32, a bifunctional regulator of redox homeostasis and stage-dependent abiotic stress tolerance in Arabidopsis

Hongmei Sun, Guangchuan Shi, Ye Tao, Na Cheng et autres

Chloroplast-localized thioredoxin-like protein CDSP32 is induced by drought stress, but its integrated roles in abiotic stress tolerance and plant development remain elusive. Here, we investigated the function of MaCDSP32 from Morus alba by heterologous overexpression (OE) in Arabidopsis thaliana, combined with analyses …

cn, np (code pays fourni par la source)

LpWRKY28 promotes embryonic callus formation in Lilium pumilum by activating LpABI5 transcription

Yue Sun, Chunxia Wang, Shengli Song, Hongmei Sun

Somatic embryogenesis (SE) is widely used in agricultural production and genetic improvement. Lilium spp. has great ornamental and economic value, and SE provides an important basis for the conservation of its germplasm and its efficient propagation and genetic improvement. However, plant SE …

cn (code pays fourni par la source)

Finotonlimab (PD-1 inhibitor) plus bevacizumab (bevacizumab biosimilar) as first-tier therapy for late-stage hepatocellular carcinoma: a randomized phase 2/3 trial

Chuanhua Zhao, Yanqiao Zhang, Gang Wang, Jinfang Zheng et autres

We aimed to assess the tolerability and efficacy of finotonlimab (an anti-programmed cell death protein-1 antibody) in combination with SCT510, a bevacizumab biosimilar, versus sorafenib in unresectable advanced HCC. This randomized phase 2 and 3 study (ClinicalTrials.gov, NCT04560894; Chinadrugtrials.org.cn, CTR20201976 and CTR20201974) …

cn (code pays fourni par la source)

An effective approach to cartilage regeneration using antler stem cell-conditioned medium

Jue Zhou, Baorui Xing, Qianqian Guo, Jianwei Zhao et autres

Articular cartilage has a low capacity for self-regeneration. Therefore, stem cell therapy has been proposed and is gaining momentum. Antler can self-repair and its cartilaginous tissue can grow at an unprecedented rate (Up to 2 cm/day) and antler regeneration is based on …

cn (code pays fourni par la source)

Plasma proteomics-based risk scores for psoriasis prediction: a novel approach to early diagnosis

Siyu Wei, Chen Sun, Yuping Zou, Haiyan Chen et autres

Introduction: Psoriasis is a chronic immune-mediated inflammatory skin disease with a significant global burden. Current risk assessment lacks integration of proteomic data with genetic and clinical factors. This study aimed to develop a plasma proteomics-based risk score (ProtRS) to improve psoriasis prediction. …

cn (code pays fourni par la source)

Antlers on does: An unexpected role of macrophages in deer biology

Datao Wang, Hengxing Ba, Xunsheng Li, Tomás Landete‐Castillejos et autres

Antlers, a male deer secondary sex characteristic, are unique mammalian appendages that fully regenerate annually, under androgen regulation. Stem cells located in the antlerogenic periosteum (AP), a tissue overlaying the frontal crest of both male and female deer, play a crucial role …

cn, es, it, tw (code pays fourni par la source)

Auxin signaling mediated embryogenic cell formation during the early stage of somatic embryogenesis in Malus domestica “Gala”

Yue Yang, Jun Wei, Yu Wang, Mingkun Chen et autres

Embryogenic cell formation is a prerequisite for somatic embryogenesis (SE) in plants. Auxin signaling is indispensable for the initiation of embryogenic cell formation. However, the mechanism of auxin signaling that regulates this process in apple remains unclear. In this study, the MdAUX/IAA7.1 …

cn (code pays fourni par la source)

Sucrose synthase genes LoSuSy and LoSuSy4 promote floral bud differentiation in lilies by degrading sucrose

Tianqi Pan, Xinyue Fan, Min Li, Hong Yuan et autres

cn (code pays fourni par la source)

Efficacy and safety of KN026 and docetaxel for HER2‐positive breast cancer: a phase II clinical trial

Jianli Ma, Jingxuan Wang, Ting Xu, Quchang Ouyang et autres

BACKGROUND: The standard first-line treatment for human epidermal growth factor receptor 2 (HER2)-positive recurrent/metastatic breast cancer currently includes pertuzumab plus trastuzumab and docetaxel. This study aimed to evaluate the effectiveness of KN026, an anti-HER2 bispecific antibody, plus docetaxel in first-line treatment of …

cn, jp (code pays fourni par la source)

Effects of Crispr/ Cas9-Mediated Igfbp3 Gene Knockout on Proliferation and Apoptosis of Antler Stem Cells

Jiali Wei, Biao Xu, Pinghui Zhang, Huitao Liu et autres