Zhe Xu

Therapeutic Effect and Mechanism of Maizhuni-Nujia, a Classic Uyghur Prescription on Reserpine-Induced Depression in Mice

Gvlzapar Tohniyaz, Wei Chen, Zhe Xu, Yanchuan Gong et autres

Introduction: Major depressive disorder is a prevalent psychiatric condition affecting millions worldwide, yet current pharmacotherapies, primarily based on monoamine modulation, are limited by delayed onset, insufficient efficacy, and adverse effects. Maizhuni-Nujia (MZNNJ) is a classic multi-herb prescription from Uyghur traditional medicine, traditionally …

From concept to practice: intra-articular photobiomodulation for knee osteoarthritis

Hao Chen, Feifei Gao, Yu Luo, Rui Wang et autres

Knee osteoarthritis (KOA) is a prevalent degenerative joint disease worldwide. Current treatments primarily offer only symptomatic relief and lack disease-modifying efficacy. Photobiomodulation therapy (PBMT) has shown potential in modulating cellular metabolism and inflammation to alleviate KOA symptoms; however, its conventional transcutaneous delivery …

cn, us (code pays fourni par la source)

Cryoprotective Effects of Tuna Skin Antifreeze Peptides on the Quality of Salmon Flesh During Low-Temperature Fluctuations

Zhe Xu, Ziyu Zhang, Zijin Qin, Tengfei Li et autres

Repetitive temperature fluctuations during transportation and storage promote ice crystal formation in salmon flesh, leading to protein denaturation, lipid oxidation, and quality loss. Tuna skin, a major by-product of tuna processing, is a potential source of antifreeze peptides (AFPs) but remains underutilized. …

cn, us (code pays fourni par la source)

Retrospective study of photodynamic therapy for the GNA-Related Capillary Malformation spectrum of pediatric patients

Rui He, Xiaoyang Wang, Li Ma, Zhe Xu et autres

• The GNA-Related Capillary malformation spectrum (GNARCMs) presents a therapeutic challenge. The clinical manifestations of the pediatric GNARCMs patients were retrospectively analyzed, and evaluated the efficacy and safety of photodynamic therapy for treating the GNARCMs of pediatric patients. In conclusion, focusing on …

cn (code pays fourni par la source)

Dissolvable Microneedle Delivery of a Replication-Deficient Orthopoxvirus Vaccine: Formulation Screening and Immunogenicity Evaluation for Monkeypox Prevention

Bin Wang, Kehui Wang, Zhe Xu, Weihua Liu et autres

Background: The global spread of monkeypox virus (MPXV) highlights an urgent need for thermostable and easily administrable vaccines. Current orthopoxvirus vaccines are limited by cold-chain dependence and inconvenient injection-based delivery. Objectives: This study aimed to develop a dissolvable microneedle (DMN) vaccine against …

cn (code pays fourni par la source)

Mechanistic insights into the roles of astragalosides and Astragalus polysaccharides in gynecological and breast cancers (Review)

Ruixin Liu, Zhanyu Lin, Yan Li, Yuetong Ci et autres

Astragalus membranaceus, a Qi-tonifying herb widely used in traditional Chinese medicine, has emerged as a promising adjuvant for female-predominant malignancies, including breast, ovarian and cervical cancers.Its major bioactive constituents, Astragalus polysaccharides (APS) and astragalosides (AST), exert multitarget antitumor activities and are widely …

cn (code pays fourni par la source)

Coenzyme Q10 exerts anti-cancer effects in bladder cancer by inducing ROS-mediated apoptosis and autophagy

Yebo Wang, Aimin Zhang, Hang Che, Jingyu Gao et autres

cn (code pays fourni par la source)

The ATF5-GPER1 axis drives female protection in hepatocellular carcinoma through dual tumor-suppressive and immune-modulatory mechanisms

Zhe Xu, Hao Wang, Qiang He, Hongshuai Cui et autres

Hepatocellular carcinoma (HCC) exhibits marked sexual dimorphism, with females demonstrating superior survival, yet the underlying molecular mechanisms remain unclear. We integrated bulk transcriptomics (GSE39791, TCGA-LIHC, GSE14520) and single-cell RNA sequencing (five datasets, n = 58 patients, 238,982 cells) with machine learning (LASSO, …

cn (code pays fourni par la source)

A living therapeutic platform for localized in situ modulation of macrophage pyroptosis ameliorates GVHD while preserving GVL

Zhuo Wan, Zhe Xu, Xuanting Liang, Yueru Ji et autres

BACKGROUND: Graft-versus-host disease (GVHD) is a major cause of morbidity and mortality following allogeneic hematopoietic stem cell transplantation, with the gastrointestinal tract being a primary target organ. Dysregulated innate immune activation, particularly within intestinal macrophages, is increasingly recognized as a key contributor …

cn (code pays fourni par la source)

βA4-Crystallin Mutations Disrupt Structural Stability and Crystallin Interactions in Congenital Cataract Pathogenesis

Xiaoshan Lin, Shasha Deng, Wenqian Li, Venkata Pulla Rao Vendra et autres

Purpose: Mutations in the crystallin beta A4 (CRYBA4) gene, which encodes βA4-crystallin, are associated with congenital cataract; yet, the underlying pathogenic mechanisms remain elusive. We systematically investigated four cataract-associated βA4-crystallin mutants (βA4-Y67N, βA4-L69P, βA4-F94S, and βA4-G147V), each representing distinct structural contexts, to …

cn, us (code pays fourni par la source)

Bridging the vertical mismatch: elevation-dependent drivers and conservation strategies for mountain biodiversity

Tao Hu, Yi’na Hu, Jiayao Shu, Zhe Xu et autres

Tao Hu, Yi’na Hu, Jiayao Shu, Zihan Xu, Qiancheng Lv, Jianquan Dong, Yanxu Liu, Jian Peng; Bridging the vertical mismatch: Elevation-dependent drivers and

ro, cn (code pays fourni par la source)

Cold‐Induced Pyroelectric Stimulation Enhances Implant Osteointegration via TRPM8 Activation

Kai Li, Zhe Xu, Xi Liu, Y. C. Xu et autres

ABSTRACT Electrical signals serve as important modulators in bone regeneration, yet recreating this self‐sustaining bioelectrical microenvironment at the peri‐implant interface remains challenging. In this study, we engineered pyroelectric nanostructure coatings on titanium (Ti) implants to enhance implant osteointegration through temperature fluctuation‐driven electrical …

cn (code pays fourni par la source)