Xiaolei Huang

Efficacy of fentanyl combined with bupivacaine and morphine for spinal anesthesia during cesarean section: A double-blind randomized controlled trial

Gehui Li, Fanfang Zeng, Xiaofei Qi, Xuhong Tan et autres

Objective Adequate anesthesia is necessary during cesarean section. We aimed to study the efficacy and safety of different doses of fentanyl combined with 10 mg bupivacaine and 0.1 mg morphine for spinal anesthesia during elective cesarean section. Method This double-blind randomized controlled …

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Neuronal TLR4 overexpression in the medial prefrontal cortex is associated with neuroinflammation and depression-like behaviors in ovariectomized rats

Xiaolei Huang, Fang-Min Wang, Yiying Zhou, Miaojun Lai et autres

cn (code pays fourni par la source)

Effect of butorphanol nasal spray administration on patient cooperativity during labor epidural placement: a single-center randomized controlled trial

Jing Sun, Fan Wu, Mingguang Wu, Guanxiong Wu et autres

BACKGROUND: Epidural block stands as the prevailing, secure, and efficient approach to labor analgesia. Inadequate maternal cooperation not only hampers anesthesia effectiveness but also may lead to severe consequences, including nerve damage due to positional changes. METHODS: A randomized controlled clinical trial …

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Protein Kinase C Epsilon Overexpression Protects the Heart Against Doxorubicin-Induced Cardiotoxicity Via Activating SIRT1

Danyong Liu, Chunyan Wang, Xiaolei Huang, Yajie Wen et autres

Doxorubicin (DOX)-induced cardiotoxicity (DIC) is known to be associated with reduction of cardiac protein kinase C epsilon (PKC-ε). PKC-ε promotes cell survival and protects hearts against various stresses. However, it is unclear whether or not the reduction in cardiac PKC-ε expression plays …

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Ibudilast‐Mediated Suppression of Neuronal TLR4 in the Prefrontal Cortex Mitigates Methamphetamine‐Induced Neuroinflammation and Addictive Behaviours

Fang-Min Wang, Huizhen Liu, Yuting Ke, Xiaolei Huang et autres

Methamphetamine (METH) use leads to addiction, neurotoxicity, and neuroinflammation. Ibudilast, a toll-like receptor 4 (TLR4) inhibitor, has been shown to reduce METH-induced neuroinflammation and self-administration, but its specific role in neuronal TLR4 signalling and associated behavioural outcomes remains poorly understood. This study …

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Effect of dural puncture epidural technique combined with programmed intermittent epidural bolus on labor analgesia: A randomized, double-blind, parallel-group, controlled clinical trial

Rouxuan Zhou, Daili Chen, Yuantao Li, Xiaolei Huang et autres

BACKGROUND: Labor analgesia can be achieved by different approaches. The efficacy and safety of combined dural puncture epidural (DPE) with program intermittent epidural bolus (PIEB) are not well characterized. This study aimed to compare the efficacy and safety of DPE combined with …

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Targeting Histone Readers: Non-bromodomain Readers

Xiaolei Huang, Yichang Chen, Qin Xiao, Xinci Shang et autres

Histone mark readers have diverse biological functions and dysregulation of these proteins is associated with various diseases. Targeting these readers through therapeutic interventions has become an exciting area of focus in drug discovery. Several modalities have been employed to develop inhibitors against …

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Longitudinal observation of tRNA ‐derived fragments profiles in gestational diabetes mellitus and its diagnostic value

Yifang Hu, Yan Liu, Jun Shen, Lihua Yin et autres

BACKGROUND: Gestational Diabetes Mellitus (GDM) poses significant risks to maternal and fetal health. Current diagnostic methods based on glucose tolerance tests have limitations for early detection. tRNA-derived small RNAs (tsRNAs) have emerged as potential molecular regulators in various diseases, including metabolic disorders. …

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Genetic Causal Relationship Between Alanine Aminotransferase Levels and Risk of Gestational Diabetes Mellitus: Mendelian Randomization Analysis Based on Two Samples

Lihua Yin, Yifang Hu, Xiaoxia Hu, Xiaolei Huang et autres

Abstract Gestational diabetes mellitus (GDM) is a frequent complication of pregnancy. The specific mechanisms underlying GDM have not yet been fully elucidated. Contemporary research indicates a potential association between liver enzyme irregularities and an increased risk of metabolic disorders, including diabetes. The …

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Comparison of the efficacy and safety of sodium valproate versus levetiracetam in the treatment of severe traumatic brain injury

Xiaolei Huang, Wenjia Lin, Jiayin Wang, Chubin Liu et autres

OBJECTIVE: To observe the efficacy and safety of sodium valproate (VPA) compared to levetiracetam (LEV) in the treatment of severe traumatic brain injury (sTBI). METHODS: In this blind, prospective study, eighty-four sTBI patients who had craniotomy from August 2021 to August 2023 …

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Phorbol Derivatives of Croton Oil

Xiaolei Huang, Xusheng Huang, Qirun Li, Liu‐Meng Yang et autres

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Chemical inhibitors targeting histone methylation readers

Xiaolei Huang, Yichang Chen, Qin Xiao, Xinci Shang et autres

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