Yitian Chen

Artemisinin Activates AMPK to Rescue Neuronal Cells and 3xTg Mice from Aβ1-42 Neurotoxicity

Yitian Chen, Wenjun Xiong, Lijun Ge, Wenhua Zheng

INTRODUCTION: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by a multifactorial etiology, including amyloid β1-42 (Aβ1-42) accumulation, oxidative stress, tau hyperphosphorylation, and neuroinflammation. Among these pathological processes, redox imbalance and inflammation are key drivers of neuronal injury and are closely …

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Fasting-Mimicking Diets Reprogram Cancer-Associated Fibroblasts to Reverse the Immunosuppressive Tumor Microenvironment in Breast Cancer

Junsheng Zhang, Ning Li, Rongrong Li, Yitian Chen et autres

Abstract Fasting-mimicking diets (FMD) have been reported to increase the antitumor efficacy in preclinical studies in various cancers. FMD can affect the tumor microenvironment (TME), and elucidating the mechanisms and cells mediating the effects of FMD may uncover combination treatment strategies. Here, …

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Integrative transcriptomic and metabolomic analysis reveals the mechanism of GABA and melatonin co-treatment enhancing flavonoid and alkaloid biosynthesis in Dendrobium officinale protocorm-like bodies

Mingfeng Liu, Yu Shao, Yitian Chen, Xiuying Xia et autres

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Long-term survival after multimodality treatment of metastatic mixed adenoneuroendocrine carcinoma of colon: A case report

Jun Pan, Rongsheng Zhang, Ying Chen, Xiaohui Cao et autres

BACKGROUND: Mixed adenoneuroendocrine carcinoma (MANEC) is a rare malignancy that can be effectively treated with surgery in its early stages. However, there is currently no established treatment protocol for metastatic cases. CASE SUMMARY: We present a case of a patient diagnosed with …

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Systolic Blood Pressure Time in Target Range and Acute Kidney Injury in Patients With Hypertension

Weihua Chen, Cheng Xi Yang, Yitian Chen, Zi-Jin Li et autres

BACKGROUND: Acute kidney injury (AKI) is a serious complication of hypertension management. However, the association between systolic blood pressure (SBP) time in target range (TTR) and the risk of AKI remains unclear. METHODS: This is a post hoc analysis of the SPRINT …

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Prognostic factors affecting survival in patients with duodenal adenocarcinoma and isolated liver metastases: a retrospective study

Jun Pan, Jie Li, Ying Chen, Yitian Chen et autres

BACKGROUND: The study aimed to identify the prognostic factors affecting survival among patients with duodenal adenocarcinoma (DAC) and isolated hepatic metastases (HM). METHODS: We conducted a retrospective analysis of clinical data from 51 patients treated for DAC and HM from January 2012 …

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Influence of antibacterial peptides in drinking water on growth and intestinal health of European meat pigeon

Yuanhao Han, Yayan Liang, Yongquan Luo, Yuanrong Cai et autres

This study evaluated insect-derived antimicrobial peptides (AMPs) as sustainable alternatives to antibiotics in European meat pigeon production. Using a randomized design, 360 breeding pairs with squabs were allocated to four groups (n = 90/group; 1:1 sex ratio). Controls received untreated water, while …

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Multi-omic-based classification for identifying optimal neoadjuvant treatment strategies for high-risk early-stage breast cancer

Fei Ji, Xianzhe Chen, Ciqiu Yang, Liulu Zhang et autres

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Erratum - Effect of CDX2 on proliferation, invasion, migration, and apoptosis of duodenal cancer cells

Jun Pan, Yi Chen Zhao, Yu Zhang, Yuhe Zhou et autres

This corrects the article published in the European Journal of Histochemistry 2025;69:4203.

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Metabolomics study on fermented soybean meal by Rhizopus oligosporus RT-3 and its improvement on the growth status of malnourished mice

Teng Fei Sun, Zhaojun Wang, Yiqiang Dai, Kang Zhai et autres

Abstract In this study, Rhizopus oligosporus RT-3 was utilized to ferment soybean meal to obtain a tempe-like food with low fat and high bioactivity. To investigate the impact of fermentation on soybean meal’s nutritional value, we detected the protein-related indices and conducted …

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Effect of CDX2 on proliferation, invasion, migration, and apoptosis of duodenal cancer cells

Jun Pan, Yi Chen Zhao, Yu Zhang, Yuhe Zhou et autres

This study investigates the expression and biological role of caudal homologous transcription factor 2 (CDX2) in duodenal carcinoma. Paraffin-embedded samples from 40 duodenal carcinoma cases were analyzed using immunohistochemistry on a tissue microarray to assess CDX2 expression and its prognostic significance. CDX2 …

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Differences in HER2-0 and HER2-low Breast Cancer: Androgen Receptor and Programmed Death Ligand 1 as Predictive Factors

Ciqiu Yang, Yitian Chen, Na Huang, Yilin Chen et autres

Purpose: Human epidermal growth factor receptor 2 (HER2)-low breast cancer has the potential to emerge as a distinct subtype.Several studies have compared the differences between HER2-low and HER2-0 breast cancers, but no consensus has been reached.Additionally, a biomarker to predict pathological complete …

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