Xianglu Rong

Panax notoginseng saponins ameliorates glucolipid metabolism disorders and hepatic injury in T2DM mice via gut microbiota modulation

Tianxin Zhu, Jie Tao, Biyuan Yang, Zhenjie Wu et autres

Background Despite low oral bioavailability, Panax notoginseng saponins (PNS) exert anti-diabetic effects, possibly through gut microbiota-mediated indirect mechanisms. Aim This study investigated whether PNS regulate glucolipid metabolism in T2DM by modulating gut microbiota and activating the FXR/SHP pathway via its metabolite PPT. …

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Atractylodes macrocephala Koidz. polysaccharides alleviate liver fibrosis in association with suppression of cGAS-STING signaling and mitochondrial apoptosis

Jiali Wu, X. Hu, Jing Liu, Hongye Peng et autres

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Atractylodes Macrocephala Polysaccharides Ameliorate Diabetic Hepatorenal Injury and Remodel Gut Microbiota in Mice

J. Y. Wu, Xuenan Liu, Yangpeng Li, Jing Liu et autres

ABSTRACT Atractylodes macrocephala polysaccharides (AMPs) are known to exert metabolic regulatory and immunomodulatory activities, yet their protective effects across multiple organs in diabetes and the mechanisms involving gut‐organ crosstalk have not been fully elucidated. In this study, we investigated the multi‐organ benefits …

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Corrigendum “The Chinese herbal medicine Fufang Zhenzhu Tiaozhi ameliorates diabetic cardiomyopathy by regulating cardiac abnormal lipid metabolism and mitochondrial dynamics in diabetic mice” [Biomed. Pharmacother. 164 (2023) 114919]

Meiling Yan, Suping Liu, Wenru Zeng, Qiaoling Guo et autres

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813-P: Machine Learning–Based Prediction Models for Initial Insulin Pump Dosing in Type 2 Diabetes Patients

Xiaoyi Wang, Xianglu Rong

Introduction and Objective: Accurate initial insulin dosing is essential for optimal glycemic control in type 2 diabetes patients with insulin pumps. Traditional weight-based estimations lack precision due to the heterogeneity of type 2 diabetes, underscoring the need for advanced predictive approaches. This …

The impact of YTHDF2-mediated NCOA4 methylation on myocardial ferroptosis

Xiaoqi Shao, Mengxian Sun, Ruonan Wang, Mingyang Leng et autres

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Basic biology and roles of CEBPD in cardiovascular disease

T Li, Shaoling Lin, Ying Zhu, Dewei Ye et autres

CCAAT/enhancer-binding protein delta (CEBPD), as an evolutionarily conserved protein in mammals, belongs to the CEBP transcription factor family, which modulates many biological processes. The diversity of CEBPD functions partly depends on the cell type and cellular context. Aberrant CEBPD expression and activity …

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Effect of high glucose on the gene expression profiling in cardiac fibroblasts from rats at different ages

Quqian Mo, Angyu Zhan, Shaoling Lin, Jiaojiao Feng et autres

Background Cardiac fibroblasts (CFs) play a vital role in the physiological and pathological processes of the heart. Previous studies have demonstrated that high glucose stimulation induces the transformation of CFs into myofibroblasts, contributing to cardiac fibrogenesis. However, in vivo experiments have predominantly …

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Preventive Administration of Quercetin Promotes Survival and Reduces Adverse Ventricular Remodeling after myocardial infarction through facilitating M2-like macrophage polarization

Lexun Wang, Shaolin Lin, Quxing Wei, Tongjun Li et autres

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Lactylation Modification in Cardiometabolic Disorders: Function and Mechanism

Xu Li, Pingdong Cai, Xinyuan Tang, Yingzi Wu et autres

Cardiovascular disease (CVD) is recognized as the primary cause of mortality and morbidity on a global scale, and developing a clear treatment is an important tool for improving it. Cardiometabolic disorder (CMD) is a syndrome resulting from the combination of cardiovascular, endocrine, …

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Th17 cells: A new target in kidney disease research

Tao Zhang, Hongyan Huo, Ying‐Hui Zhang, Jie Tao et autres

T helper cells, secrete pro-inflammatory cytokines such as IL-17A, IL-17F, IL-21, IL-22, and GM-CSF, which play crucial roles in immune defence and protection against fungal and extracellular pathogen invasion. However, dysfunction of Th17 cell immunity mediates inflammatory responses and exacerbates tissue damage. …

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The blockade of the TGF ‐β pathway alleviates abnormal glucose and lipid metabolism of lipodystrophy not obesity

W. Xu, S. Lai, Jia Zhao, Xue‐Ying Fang et autres

TGF-β is thought to be involved in the physiological functions of early organ development and pathological changes in substantial organ fibrosis, while studies around adipose tissue function and systemic disorders of glucolipid metabolism are still scarce. In this investigation, two animal models, …

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