Gaiping Zhang

Multi-scenario deployable analysis platform for the detection of illicit pharmaceutical adulteration in dietary supplements

Yuxin Wang, Wanzi Yao, Yifeng Zhang, Gaiping Zhang

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Integrating functional ingredients in food into ageing research: implications for lifespan and healthspan

Wanzi Yao, Yuxin Wang, Zhengjie Kong, Kaifeng Guan et autres

Abstract As the global population ages at an unprecedented rate, identifying effective strategies to extend lifespan and mitigate age-related diseases has become imperative. Current research in nutrition for healthy ageing has increasingly focused on functional ingredients in food known to enhance longevity. …

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Palmitoylation enhances the stability of porcine epidemic diarrhea virus spike protein by antagonizing its degradation via chaperone-mediated autophagy to facilitate viral proliferation

Qisheng Qian, Shuangshuang Zhao, Lei Yang, Guangxu Xing et autres

Porcine epidemic diarrhea (PED) is a highly pathogenic and infectious intestinal disease caused by the PED virus (PEDV) and has inflicted substantial economic losses on the global swine industry. Therefore, it is imperative to explore appropriate targets to restrain PEDV infection. PEDV …

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Comparison of Different Methods of Constructing a Celiac Disease Model in BALB/c Mice

Kexin Hu, Hongtao Ren, Chong Yuan, Zhigang Liu et autres

Efficient and stable animal models of celiac disease (CD) are crucial for CD research, dietary supplementation research, and new drug development. This study aimed to establish CD models by administering gliadin to parental and first-generation mice on a gluten-free diet using two …

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MHC-I pathway disruption by viruses: insights into immune evasion and vaccine design for animals

Yanan Wu, Zhuoya Sun, Lu Xia, Panpan Tian et autres

Among various pathogens, viruses pose significant threats to the livestock and poultry industry, resulting in substantial annual costs due to production losses and vaccination. The MHC-I presentation pathway is a crucial surveillance mechanism for preventing viral infections. Consequently, many viruses have evolved …

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Subcellular proteomics reveals the crosstalk between nucleocytoplasmic trafficking and the innate immune response to Senecavirus A infection

Mingyang Li, Xiaoshuang Deng, Menghan Zhou, Wen-Rui He et autres

Mounting evidence suggests that a number of host nuclear-resident proteins are indispensable for the replication of picornaviruses, a typical class of cytoplasmic RNA viruses. Host nucleocytoplasmic transport is often hijacked by viruses to promote their replication in the cytoplasm of infected cells, …

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Development of monoclonal antibodies for ASFV K205R protein and precise mapping of linear antigenic epitopes

Lei Zhou, Jinxing Song, Zhuoya Sun, Mengxiang Wang et autres

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Machine Learning-Driven Methods for Nanobody Affinity Prediction

Hua Feng, Xuefeng Sun, Ning Li, Qian Xu et autres

Because of their high affinity, specificity, and environmental stability, nanobodies (Nbs) have continuously received attention from the field of biological research. However, it is tough work to obtain high-affinity Nbs using experimental methods. In the current study, 12 machine learning algorithms were …

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Oral administration of antimicrobial peptide MPX ameliorates orchitis and inflammatory damage in other organs

Chunling Zhu, Yilin Bai, Rui Song Yang, Boyang Zhang et autres

Bacterial orchitis has a very high percentage of reproductive diseases in males. Therefore, specific medicines are urgently needed to prevent and treat orchitis. Antimicrobial peptides (AMPs) are widely recognized as one of the most promising substitutes for antibiotics. However, it is unknown …

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Preparation and epitope analysis of monoclonal antibodies against African swine fever virus DP96R protein

Chao Li, Xuanying Si, Xiaoge Wang, Zhiwei Yan et autres

BACKGROUND: Many proteins of African swine fever virus (ASFV, such as p72, p54, p30, CD2v, K205R) have been successfully expressed and characterized. However, there are few reports on the DP96R protein of ASFV, which is the virulence protein of ASFV and plays …

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A novel conserved B-cell epitope in pB602L of African swine fever virus

Jinxing Song, Mengxiang Wang, Lei Zhou, Panpan Tian et autres

Abstract African swine fever virus (ASFV) is a complex DNA virus and the only member of the Asfarviridae family. It causes high mortality and severe economic losses in pigs. The ASFV pB602L protein plays a key role in virus assembly and functions …

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Establishment and characterization of a novel indirect ELISA method based on ASFV antigenic epitope-associated recombinant protein

Jiaxin Jin, Yilin Bai, Yuanyuan Zhang, Wenlong Lu et autres

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