Yanyan Han

A rapid fluorescence-based viability screening protocol for large, mechanically prepared patient-derived organoids

Xin Zhang, Mingjie Rong, Wenbo Qian, Jiping Liu et autres

Patient-derived organoids (PDOs) established via mechanical processing retain critical cellular components from the native microenvironment, including stromal elements. However, the macro-scale architecture of these organoids poses significant challenges for conventional viability assessment, often necessitating destructive processing or specialized imaging equipment. We developed …

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Cell-type-specific regulators landscape and regulatory mechanisms underlying pyroptosis in uterine corpus endometrial carcinoma

Hongrui Guo, Jinpeng Li, Fucheng Wang, Jiaolin Yang et autres

Background: Endometrial cancer (UCEC) has a significant detrimental effect on patient quality of life.Although pyroptosis-related genes have been reported to contribute to tumor pathogenesis, the specific mechanism of pyroptosis in patients with UCEC remains elusive. Methods:We provide an overview of the landscape …

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Abstract 26: An HLA-class II restricted HPV18 E7 specific TCR cloned from a long-term surviving cervical cancer patient

Jianting Long, Xihe Chen, Shudan Ou, Minjun Ma et autres

Abstract T cell receptor (TCR)-engineered T cell therapy is a promising approach for the treatment of solid malignancy, with multiple clinical trials reporting impressive responses using affinity-matured TCRs. However, artificially mutated TCRs can increase the risk of off-target toxicities due to unexpected …

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Abstract 27: A single amino acid mutated AFP specific T cell receptor uniting synergistic functionalities of CD4 and CD8 T Cells with no cross-activity

Chen‐Song Huang, Shali Ou, Jun Li, Junjun Chu et autres

Abstract Background: Genetically engineered T cells with T cell receptor (TCR-T) cell therapy have shown great potential for cancer treatment by targeting tumor-associated antigens. Despite its success in treating various tumor types, such as synovial sarcoma, head and neck tumors, and cervical …

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Delineation of the “Oropharyngeal Mucosa” and Limiting its Dose in Head and Neck Cancer Patients Spares the Oropharynx Without Compromising Target Coverage

Xueqi Wang, Yanyan Han, Zhi Zheng, Wenzhong Xu et autres

Objectives Radiation-induced oropharyngeal injury is a dose-limiting toxicity in head and neck cancer patients. Delineation of the “oropharyngeal mucosa” and limiting its dose to spare the oropharynx was investigated. Methods In this retrospective study, computed tomography imaging from eight patients with previously …

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A case of unilateral sclerosing stromal tumor of the ovary in a postmenopausal female

Chao Gao, Yanyan Han, Xiangqin Fan, Haiwei Dong et autres

Synopsis Although SSTs predominantly affect young women, postmenopausal women with pelvic masses should not be overlooked. A comprehensive approach is necessary for diagnosis of this tumor.

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Evaluating the impact of metformin targets on the risk of heart failure: a Mendelian randomization study

Pan He, Ziqiang Guo, Yanyan Han, Anping Deng et autres

Abstract Background With conflicting findings in observational studies, the efficacy of metformin in improving heart failure outcomes remains inconclusive. This study employs a two-sample Mendelian randomization design, using AMP-activated protein kinase (AMPK) and growth differentiation factor 15 (GDF-15) as pharmacological targets of …

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Effect of arbuscular mycorrhizal fungi and phosphorus on drought-induced oxidative stress and 14-3-3 proteins gene expression of Populus cathayana

Yanyan Han, Wenrui Zhang, Tingying Xu, Ming Tang

The application of arbuscular mycorrhizal fungi (AM fungi) and phosphorus (P) can improve plant growth under drought stress by upregulating the antioxidant system and osmotic accumulation. The 14-3-3 protein can respond to different abiotic stresses such as low P and drought. The …

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Arbuscular Mycorrhizal Fungi Enhanced Drought Resistance of Populus cathayana by Regulating the 14-3-3 Family Protein Genes

Yanyan Han, Xiao Lou, Wenrui Zhang, Tingying Xu et autres

14-3-3s under drought stress remain poorly resolved and the mechanisms of action of these genes in mycorrhizae-induced drought stress are still unknown. Thus, studying the drought-resistance mechanism of the AMF symbiotic plant 14-3-3 gene is of special significance to improving the drought …

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Abstract 5569: Discovery of tumor-specific T cell receptors (TCRs) by reverse genetic engineering platform

Yanyan Han, Xiaoling Liang, Shudan Ou, Xihe Chen et autres

Abstract TCR-T therapy is an ideal cell therapeutic strategy against solid tumors. However, the traditional method of TCR cloning has two major problems. First, we could only develop TCRs against previously discovered tumor antigen epitopes. Second, the affinity maturation of TCR sometimes …

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SAT0209 PREVALENCE AND RELATED FACTORS OF SLEEP DISTURBANCE IN PATIENTS WITH PRIMARY SJÖGREN'S SYNDROME

Yanyan Han, Li Long, X. Chen, Guoyao Tang et autres

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Knockdown of long noncoding RNA TP73‐AS1 suppresses the malignant progression of breast cancer cells in vitro through targeting miRNA‐125a‐3p/metadherin axis

Yuxiong Liu, Guangqing Wei, Qian Ma, Yanyan Han

BACKGROUND: TP73 antisense RNA 1 (TP73-AS1) is a long noncoding RNA which has been shown to be involved in the progression of multiple malignant tumors. Previous studies have demonstrated the oncogenic role of TP73-AS1 in breast cancer. However, its molecular mechanism remains …

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