Jing Pei

Correction to “Discovery of Dual BCL-xL/BCL-w Degraders by Exploiting the Bis(sulfonyl)benzene Ring of ABT-263 as a Linkage Vector”

Saikat Kumar Poddar, Yang Yang, Pratik Pal, Zeng Jin et autres

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Mechanism of TRIM32 regulation of synaptic protein expression in the development of epilepsy in a rat model

Ming Chen, Jing Pei

Accumulating evidence indicates that tripartite motif-containing protein 32 (TRIM32) has important functions in brain physiology and disease. This study investigated the role of TRIM32 in the development of epilepsy and its impact on synaptic remodeling. A rat model of epilepsy was established …

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Discovery of Dual BCL-xL/BCL-w Degraders by Exploiting the Bis(sulfonyl)benzene Ring of ABT-263 as a Linkage Vector

Saikat Kumar Poddar, Yang Yang, Pratik Pal, Jing Pei et autres

Abstract Targeting antiapoptotic proteins BCL-xL, BCL-2, and BCL-w has been extensively investigated for cancer treatment. However, robust inhibition of BCL-xL by conventional inhibitors, such as ABT-263, causes thrombocytopenia, a notable drawback that limits the clinical utility of this strategy. To overcome this …

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E3 ubiquitin ligase Pellino1 suppresses acinar cell necroptosis and alleviates severe acute pancreatitis by promoting ubiquitin‐dependent receptor‐interacting protein kinase 3 (RIP3) degradation

Jiatong Chen, Zhiwei Huang, Jing Pei, Hao Shi et autres

BACKGROUND AND PURPOSE: Severe acute pancreatitis (SAP) is a critical abdominal condition with high mortality rates. The activation of necroptosis in acinar cells is an critical mechanism for SAP. Pellino1 (PELI1), as an E3 ubiquitin ligase, is involved in pathogenic mechanisms in …

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Biodegradation of polyurethane plastic monomer 4,4′-methylenedianiline by Rhodococcus sp. YXP8

Junbin Ji, Jing Pei, Fanghui Ding, Jie Zhou et autres

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Machine learning and single-cell analysis uncover distinctive characteristics of CD300LG within the TNBC immune microenvironment: experimental validation

Baoxi Zhu, Hong Wan, Zichen Ling, Han Jiang et autres

Investigating the essential function of CD300LG within the tumor microenvironment in triple-negative breast cancer (TNBC). Transcriptomic and single-cell data from TNBC were systematically collected and integrated. Four machine learning algorithms were employed to identify distinct target genes in TNBC patients. Specifically, CIBERSORT …

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Single-cell and transcriptome analyses revealed CTHRC1 a potential therapeutic target mediating invasion and tumor microenvironment in TNBC: experimental validation

Hong Wan, Zichen Ling, Yuwei Xie, Han Jiang et autres

Background: Investigating the pivotal role of CTHRC1 in the tumor microenvironment of triple-negative breast cancer (TNBC). Method: The RNA transcriptomic data obtained from the Cancer Genome Atlas and single-cell sequencing data from TNBC in Gene Expression Omnibus (GEO) were acquired and subjected …

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Isolation and characterization of polyester polyurethane-degrading bacterium Bacillus sp. YXP1

Junbin Ji, Jing Pei, Fanghui Ding, Caiting Zeng et autres

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Effects of miR-204-5p and Target Gene EphB2 on Cognitive Impairment Induced by Aluminum Exposure in Rats

Wei Liu, Jie Gao, Niping Hao, Jing Li et autres

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The Role of Histone H2B Acetylation Modification in Aluminum-Induced Cognitive Dysfunction

Jie Gao, Wei Liu, Jing Pei, Jing Li et autres

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The Role of Acetylation and Methylation of Rat Hippocampal Histone H3 in the Mechanism of Aluminum-Induced Neurotoxicity

Jie Gao, Wei Liu, Jiaqi Liu, Niping Hao et autres

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Piperlongumine conjugates induce targeted protein degradation

Jing Pei, Yufeng Xiao, Xingui Liu, Wanyi Hu et autres

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