Ping Xie

Microglial TSPAN4‐Dependent Migrasomes Promote Pathological Retinal Neovascularization via Immune‐Vascular Crosstalk

Jingyi Xu, Jingfan Wang, Pengfei Ge, Qinyuan Gu et autres

Diabetic retinopathy (DR) is a leading cause of vision loss among working-age adults worldwide, yet the microglial mechanisms driving pathological retinal neovascularization (RNV) remain incompletely understood. By integrating single-cell transcriptomic profiling of human fibrovascular membranes with murine disease models, we identified a …

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Ectoine Inhibits IL-1β-Induced Inflammation by Suppressing the NF-κB Pathway in Chondrocytes and Alleviates Osteoarthritis in a Rat Model

Peng Li, Ping Xie, Lishuai Miao, Mingdong Li et autres

Background: Osteoarthritis (OA) is a degenerative joint disease characterized by inflammation and cartilage destruction, partly mediated by interleukin (IL)-1β-induced nucle factor (NF)-κB activation. Ectoine (Ec) is a natural osmoprotectant with anti-inflammatory properties; however, its effects on NF-κB signaling in OA remain unclear. …

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Sustained A2AR expression and loss paradoxically promote CD8 + T cell exhaustion

吕松 Lü Song, Arjun Kharel, Ping Xie, Jie Fan et autres

Although A2AR is a key immunoregulatory receptor that suppresses CD8 + T cell activation in response to elevated extracellular adenosine in inflamed or hypoxic microenvironments, its role in CD8 + T cell differentiation and cell-fate decisions during chronic viral infection and cancer …

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Abstract 617: OSTM1 is a ubiquitin E3 ligase that suppresses B-cell malignancy by activating the cAMP/PKA pathway.

Muhammad Usama Tariq, Namratha Sheshadri, Julia Shen, Jaeyong Jung et autres

Abstract Osteoclastogenesis-associated transmembrane protein 1 (OSTM1) is a membrane-integral glycosylated protein that regulates lysosomal homeostasis and osteoclast maturation. Its loss-of-function mutations cause autosomal recessive osteopetrosis (ARO). In addition, OSTM1 was described as a putative ubiquitin E3 ligase yet with ill-defined substrates and …

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Fever with Eosinophilia and Bone Marrow Granulomas in an Elderly Female: A Rare Case Report and Literature Review

Ping Xie, Yuting Zhang, Jinli Jiang, Caiping Chen et autres

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OSTM1 is a ubiquitin E3 ligase that suppresses B-cell malignancy by activating the cAMP/PKA/CREB pathway

Muhammad Usama Tariq, Namratha Sheshadri, Jianliang Shen, Jaeyong Jung et autres

Abstract Osteoclastogenesis-associated transmembrane protein 1 (OSTM1) is a membrane-integral glycosylated protein known for regulating lysosomal homeostasis, with loss-of-function mutations causing autosomal recessive osteopetrosis. Through a whole-genome CRISPR/Cas9 screen, we identified OSTM1 as a critical tumor suppressor in B-cell malignancies. In humans, OSTM1 …

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One‐Year Outcome of Vitreous Cortex Remnants Removal Using a Nitinol Flex Loop for Recurrent Retinal Detachment Patients

Zhan Xie, Yifan Lin, Haiyue Xie, Mulong Du et autres

Purpose To evaluate the 1‐year outcome of vitreous cortex remnants (VCRs) removal using a nitinol flex loop during pars plana vitrectomy (PPV) in the treatment of recurrent retinal detachment (rRD). Patients and Methods A total of 95 eyes from 95 patients with …

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An Integrated Multi-Omics Analysis Identifies Oxeiptosis-Related Biomarkers in Diabetic Retinopathy

Jiaoyu Deng, Pengfei Ge, Ying Gao, Hongying Li et autres

Background: Diabetic retinopathy (DR), a leading cause of blindness, lacks early biomarkers and mechanism-targeted therapies. While oxidative stress drives DR pathogenesis, the role of oxeiptosis—a reactive oxygen species-induced, caspase-independent cell death pathway—remains largely unexplored. Methods: We integrated transcriptomic profiling (GSE221521: 69 DR …

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Brain-Controlled Robotic Arm System Based on Dynamic Real-Scene Steady-State Visual Evoked Potentials

Ping Xie, Qingyang Wei, Jiale Zhen, Xiening Shao et autres

Abstract Brain-controlled robotic arm systems represent a crucial pathway to enhancing the autonomy of individuals with severe motor disabilities. However, traditional systems are constrained by abstract artificial stimulation interfaces and unidirectional control modes, suffering from issues such as low ecological validity, high …

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Dual Pro‐Angiogenic and Pro‐Fibrotic MARCO + Microglial Phenotype in Diabetic Retinopathy

Qinyuan Gu, Xiying Mao, Jingyi Xu, Pengfei Ge et autres

ABSTRACT Proliferative diabetic retinopathy (PDR) is a complication of diabetic microangiopathy that can cause severe visual impairment. Due to retinal neovascularization and fibrovascular membrane (FVM) formation, inhibition of vascularization and fibrosis plays a key role in PDR. In our study, single‐cell sequencing …

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Minimizing radiation dose in coronary CT angiography using dual single-cardiac phase acquisition with a whole-heart motion correction technology: a prospective randomized study on image quality

Xin Fang, Shuang Li, Ping Xie, Huanrui Hu et autres

Background: Coronary computed tomography angiography (CCTA) plays an increasingly important role in coronary artery disease (CAD) evaluation, but radiation dose remains a clinical concern. Conventional multi-cardiac phase (CMP) scanning covers wide R-R intervals to ensure optimal image quality, leading to higher radiation …

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The Role of Exosomes in the Lens

Ting Pan, Tianhao Xiao, Jingfan Wang, Weida Xu et autres

Exosomes are small membrane-bound vesicles which have emerged as crucial mediators in various biological and pathological processes, as well as potential therapeutic delivers. In recent years, the role of exosomes in the lens, a specialized tissue essential for vision, has been stressed. …

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