Liyi Huang

Neuroinflammation in Spinal Cord Injury: Cellular and Molecular Mechanisms

Xia Sun, Liyi Huang, Lu Wang, Li Li et autres

Traumatic spinal cord injury (SCI) elicits a coordinated cascade of innate and adaptive immune responses that evolve from the acute to the chronic phase and strongly influence regeneration and functional outcomes. This review synthesizes phase-specific pathobiology and the roles of microglia and …

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Breaking the hypoxia barrier: Advances and challenges of hyperbaric oxygen therapy in cancer treatment

Liang Zhou, Yong Xia, Chengsen Jia, Liyi Huang

Tumor hypoxia represents a fundamental barrier to effective cancer therapy, driving resistance to chemotherapy, radiotherapy, and immunotherapy while fostering invasion and metastasis. Hyperbaric oxygen therapy (HBOT), by substantially increasing dissolved oxygen in plasma, offers a unique approach to reoxygenate tumors and remodel …

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Mechanistic and Biomarker Roles of Cell Adhesion Molecules in Spinal Cord Injury: Evidence from Clinical and Molecular Analyses

Hongxia Pan, Mingfu Ding, Fei Xie, Xin Sun et autres

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Harnessing spinal circuit reorganization for targeted functional recovery after spinal cord injury

Xin Sun, Lijuan Li, Liyi Huang, Yuxuan Li et autres

Spinal cord injury (SCI) disrupts the communication between the brain and spinal cord, resulting in the loss of motor function below the injury site. However, spontaneous structural and functional plasticity occurs in neural circuits after SCI, with unaffected synaptic inputs forming new …

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The Association Between Neutrophil‐to‐Lymphocyte Ratio, Atherogenic Index of Plasma, and Cardiovascular Disease Incidence

Hongxin Cheng, Wen Zhong, Hanbin Li, Lu Wang et autres

Background: With the incidence of cardiovascular disease (CVD) escalating annually, the significance of investigating the correlation between inflammatory markers and lipid‐related indices, notably the neutrophil‐to‐lymphocyte ratio (NLR) and atherogenic index of plasma (AIP), is increasingly paramount. This study aimed to elucidate the …

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Cell transplantation therapies for spinal cord injury focusing on bone marrow mesenchymal stem cells: Advances and challenges

Liyi Huang, Xin Sun, Hongxia Pan, Lu Wang et autres

Spinal cord injury (SCI) is a devastating condition with complex pathological mechanisms that lead to sensory, motor, and autonomic dysfunction below the site of injury. To date, no effective therapy is available for the treatment of SCI. Recently, bone marrow-derived mesenchymal stem …

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CD44 promotes angiogenesis in myocardial infarction through regulating plasma exosome uptake and further enhancing FGFR2 signaling transduction

Qing Zhang, Li Chen, Liyi Huang, Hongxin Cheng et autres

BACKGROUND: Since angiogenesis occurs as the pathological process following myocardial infarction to alleviate ischemia, therapeutic angiogenesis has been proposed to be a cardioprotective strategy. CD44 has been implicated in endothelial cell functions and its role has been well established in angiogenesis for …

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Effectiveness of robotic-assisted gait training on cardiopulmonary fitness and exercise capacity for incomplete spinal cord injury: A systematic review and meta-analysis of randomized controlled trials

Ran Li, Mingfu Ding, Jiao Wang, Hongxia Pan et autres

Objective To determine the effects of robotic-assisted gait training on cardiopulmonary fitness and exercise capacity for people with incomplete spinal cord injury. Methods PubMed, Embase, Web of Science, PEDro, CENTRAL and CINAHL were searched from inception until September 4, 2022. Randomized controlled …

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Bone marrow mesenchymal stem cells and exercise restore motor function following spinal cord injury by activating PI3K/AKT/mTOR pathway

Wei Quan, Xin Sun, Liyi Huang, Pan Hong-xia et autres

Although many therapeutic interventions have shown promise in treating spinal cord injury, focusing on a single aspect of repair cannot achieve successful and functional regeneration in patients following spinal cord injury . In this study, we applied a combinatorial approach for treating …

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Enhanced effect of combining bone marrow mesenchymal stem cells (BMMSCs) and pulsed electromagnetic fields (PEMF) to promote recovery after spinal cord injury in mice

Liyi Huang, Xin Sun, Lu Wang, Gaiqing Pei et autres

Spinal cord injury (SCI) is a destructive traumatic disease of the central nervous system without satisfying therapy efficiency. Bone marrow mesenchymal stem cells (BMMSCs) therapy promotes the neurotrophic factors' secretion and axonal regeneration, thereby promoting recovery of SCI. Pulsed electromagnetic fields (PEMF) …

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Reference values and the Z-score values of tricuspid annular plane systolic excursion in Chinese children

Danlei Chen, Jinghui Guo, Bo Liu, Chunhua Zheng et autres

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Effects of Curcumin-mediated photodynamic therapy on autophagy and epithelial-mesenchymal transition of lung cancer cells

Lan Shao, Ying Zhu, Bo Liao, Wang Gailan et autres

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