Yifan Lu

Integrative Omics Analysis Reveals a CD206 + Macrophage/Dendritic Cell–CD155–TIGIT + Regulatory T Cell Axis as a Protective Immune Checkpoint Pathway in Atherosclerosis Progression

Ying Shao, Fatma Saaoud, Mohammed Ben Issa, Keman Xu et autres

ABSTRACT RNA sequencing (RNA‐seq) analysis revealed transcriptional features indicative of sustained immunosuppression within regulatory T cells (Tregs) isolated from atherosclerotic tissues, highlighting the critical contribution of immune checkpoint (ICP) receptor–ligand interactions to atherosclerosis progression. To comprehensively characterize the roles of ICP signaling …

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Microelectric Field Engineering in Carboxyl-Rich Polymeric Photocatalysts for Enhanced Exciton Dissociation and pH-Responsive Environmental Photocatalysis

Yu Zhao, Xinghao Zhang, He Zhang, Qingkun Liu et autres

Abstract Polymeric photocatalysts demonstrate significant potential for environmental remediation and energy conversion due to their tailorable structures and multifunctional integration. However, their practical applications are severely limited by intrinsic bottlenecks, especially the sluggish exciton dissociation and rigorous synthetic conditions. Herein, a strategy …

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Editorial: Therapeutic targeting of cell death in cardiovascular diseases: from mechanisms to clinical applications

Haiyan Xiang, Mohammed Ben Issa, Keman Xu, Shih-Yu Hung et autres

Recent advances in cell death research and therapeutics have significantly expanded beyond the traditional apoptosis-centered paradigm 1,2 . In last 50 years, we have experienced evolution of many cell death research focuses such as development-induced cell death, tumorigenesis-related cell death 3 , …

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Reduced R-loop abundance at proinflammatory loci: a shared epigenetic mechanism in inflammatory and metabolic diseases

William Y. Yang, Fatma Saaoud, Keman Xu, Mohammed Ben Issa et autres

Introduction: R-loops, RNA-DNA hybrid structures with a displaced single-stranded DNA loop, are key regulators of transcriptional control, chromatin architecture, and genome stability and have emerging roles in inflammatory signaling. However, the relationship between R-loop abundance and strongly modulated inflammatory effector genes in …

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Editorial: Clinical trials in cardiovascular medicine: 2025—addressing residual cardiovascular risks through precision-guided approaches

Euscia Y. Wang, Keman Xu, Ying Shao, Yifan Lu et autres

Cardiovascular disease is the leading cause of morbidity and mortality worldwide 1 and its prevalence increases with population aging. Coronary heart disease (CHD) has ranked first in disease burden despite substantial advances in pharmacotherapy, interventional cardiology, and preventive medicine. Major risk factors …

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Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications

Keman Xu, Shih-Yu Hung, Fatma Saaoud, Ying Shao et autres

Immunity has traditionally been viewed through the lens of extracellular pathogen recognition and intercellular immune communication. However, emerging evidence reveals that immune regulation extends deeply into the intracellular space, where organelles function and metabolism as active immune signaling platforms. In this review, …

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Strangulated Small Bowel Obstruction Caused by a Migrated Ring-Shaped Intrauterine Device: Two Case Reports and a Literature Review

Yifan Lu, Jiaxu Zhu, Zi Wang, Xiangtian Shi et autres

BACKGROUND Small bowel obstruction (SBO) is a common surgical emergency, most frequently caused by postoperative adhesions or hernias. SBO resulting from migration of an intrauterine device (IUD) is exceedingly rare but can be life‑threatening. CASE REPORT We present 2 cases of postmenopausal …

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ADT-OH promotes mitophagy and suppresses the cytosolic mtDNA-cGAS-STING inflammatory cascade in microglia

Xiao‐Ou Hou, Miao Wang, Rong Deng, Yifan Lu et autres

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AI tour guides: the role of conversation style and destination type

Huili Yan, Tian Tian, Yifan Lu, Hao Xiong

Purpose On the basis of congruity theory and language expectancy theory, this study aims to investigate the effect of artificial intelligence (AI) tour guides’ conversation style and destination type congruity on consumers’ continuance usage intention. Design/methodology/approach Three scenario-based experiments were conducted with …

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Mulberrin Alleviates Renal Ischemia–Reperfusion by Inhibiting Ferroptosis and Oxidative Stress Through Sirt3 Activation

Qiangmin Qiu, Zhan Chen, Wen‐Bin Yang, Yujie Zhou et autres

Background: Renal ischemia–reperfusion (I/R) injury represents a principal etiologic factor in acute kidney injury (AKI), in which ferroptosis plays a critical role. Mulberrin (Mul), a prenylated flavonoid with antioxidative properties, has an as-yet undefined role in renal I/R injury. Methods: We established …

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Watching eyes effect: the impact of eye cues on tourists’ uncivilized behavior

Huili Yan, Yifan Lu, Yuzhi Wei, Hao Xiong

Tourists’ uncivilized behavior has become a significant challenge to the sustainable development of tourism, necessitating effective management strategies. Drawing on the watching eyes effect theory, this study incorporates eye cues into the design of informational signage to explore the effectiveness of this …

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Synaptic Dysfunction in the Anterior Cingulate Cortex Underlies Pain‐Anxiety Comorbidity in a Mandibular Asymmetry Mouse Model

Zhaoyichun Zhang, Yanran Zhang, Jialin Si, Honghui Mao et autres

Structural craniofacial abnormalities, particularly mandibular asymmetry (MA), are increasingly recognized as key drivers of orofacial pain and emotional comorbidities, although the underlying neural mechanisms remain unclear. This study aims to develop a preclinical MA model to investigate the dynamic interplay between craniofacial …

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