Teng Xue

In situ Discovery of Immune Repertoire Reveals Antitumor Immunity and Therapeutic Antibodies

Haorui Zhang, Peiyu Wang, Yahui Zhao, Lukai Yang et autres

ABSTRACT Spatial transcriptomics offers a glimpse into the immunology of tissues. However, limitations in spatial transcriptomics preclude the detection of highly diverse, low-abundance, and previously unknown sequences, including immune repertoires and microbiota. Here, we introduce Archimap, a spatial transcriptomic platform that simultaneously …

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Citrullination of AKT2 Catalyzed by PAD1 Facilitates the Maintenance of Stemness Characteristics of Ovarian Cancer Stem‐Like Cells in Ovarian Cancer

Teng Xue, Xiaoqiu Liu, Chao Song, Shujia Fei et autres

Abstract The presence of ovarian cancer stem‐like cells (OCSLCs) is a crucial driving force for malignant progression, metastasis, and tumor recurrence of ovarian cancer (OC). However, the mechanisms underlying activation and maintenance of OCSLC stemness remain unclear. Here, it is identified an …

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Perturbation of calreticulin potentiates CD8+ T cell–mediated antitumor immunity

Kaiyang Tang, Lijian Wu, Yuanzhi Hu, Teng Xue et autres

Effective immunotherapy relies on the presentation of tumor-derived neoantigens on the major histocompatibility complex class I (MHC-I) to activate CD8+ T cells. Deficiencies in this process are a key mechanism of immune evasion and resistance to checkpoint blockade. In this study, using …

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[Retracted] PADI4‑mediated epithelial‑mesenchymal transition in lung cancer cells

Meiyan Liu, Yang Qu, Teng Xue, Ying Xing et autres

Following the publication of this paper, it was drawn to the Editor’s attention by a concerned reader that certain of the western blot data shown in Fig. 5C on p. 5092 were strikingly similar to data that had already been published in …

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Integrating bioinformatics and machine learning to discover sumoylation associated signatures in sepsis

Teng Xue, Qi Wang, Jinling Ma, Dongmei Li

Small Ubiquitin-like MOdifier-mediated modification (SUMOylation) is associated with sepsis; however, its molecular mechanism remains unclear. Herein, hub genes and regulatory mechanisms in sepsis was investigated. The GSE65682 and GSE95233 datasets were extracted from public databases. Differential analysis and Weighted Gene Co-expression Network …

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Integrated computational analysis identifies therapeutic targets with dual action in cancer cells and T cells

Ce Luo, Rui Zhang, Rui Guo, Lijian Wu et autres

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Inhibiting MEK1 R189 citrullination enhances the chemosensitivity of docetaxel to multiple tumour cells

Teng Xue, Shujia Fei, Jian Gu, Nan Li et autres

Drug resistance is still a big challenge for cancer patients. We previously demonstrated that inhibiting peptidylarginine deiminase 2 (PADI2) enzyme activity with Cl-amine increases the efficacy of docetaxel (Doc) on tamoxifen-resistant breast cancer cells with PADI2 expression. However, it is not clear …

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Bclaf1 regulates c‐FLIP expression and protects cells from TNF‐induced apoptosis and tissue injury

Rui Zhang, Teng Xue, Anwen Shao, Yue Lang et autres

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The role of emodin on cisplatin resistance reversal of lung adenocarcinoma A549/DDP cell

Teng Xue, Shu Ya Wang, Yuan Qi Shi, Xiao Fan et autres

Exploring drugs that reverse drug resistance and increase the sensitivity of chemotherapy drugs could significantly improve treatment effect of cancer. Our study explored the reversal effect and possible molecular mechanisms of emodin on cisplatin resistance in A549/DDP cells. The IC50 and resistance …

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PADI2‐Catalyzed MEK1 Citrullination Activates ERK1/2 and Promotes IGF2BP1‐Mediated SOX2 mRNA Stability in Endometrial Cancer

Teng Xue, Xiaoqiu Liu, Mei Zhang, E Qiukai et autres

Abstract Peptidylarginine deiminase II (PADI2) converts positively charged arginine residues to neutrally charged citrulline, and this activity has been associated with the onset and progression of multiple cancers. However, a role for PADI2 in endometrial cancer (EC) has not been previously explored. …

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HSP70 regulates cell proliferation and apoptosis in actinomycin-D-treated lung cancer cells

Kai Zhang, Ruonan Zhai, Teng Xue, Xiaoyan Xu et autres

BACKGROUND: Heat-shock protein 70 (HSP70) is a member of the heat-shock protein family which is expressed in various types of cancer and associated with apoptosis in cancer cells. However, the role of HSP70 in the regulation of c-Jun N-terminal kinase (JNK) and …

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HLA-B-associated transcript 3 (Bat3) stabilizes and activates p53 in a HAUSP-dependent manner

Rui Zhang, Di Cui, Teng Xue, Yue Lang et autres

The p53 pathway is a highly complex signaling network including several key regulators. HAUSP is a critical component of the p53 pathway acting as a deubiquitinase for both p53 and its key repressor Mdm2. Here, we identified a novel HAUSP-interacting protein, HLA-B-associated …

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