Ya Zhou

Photodynamic inactivation using natural pigments: Dual-ROS mechanisms, delivery strategies, and applications in food preservation

Lei Zhao, Ya Zhou, Dingding Duan, Rui Liu et autres

Growing demand for additive-free preservation has intensified safety concerns for fresh-cut and minimally processed foods. This review synthesizes current evidence on natural pigments as light-activated antimicrobial agents in food systems via photodynamic inactivation (PDI). Under food-grade visible light, these pigments generate reactive …

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Natural phenolics as multitarget antimicrobials for food preservation: mechanisms of action

Lei Zhao, Ya Zhou, Qingshan Shen, Jingxuan Ke et autres

Natural phenolics are emerging as promising clean-label antimicrobials, yet evidence for their multitarget mechanisms remains scattered. This review synthesizes 158 studies (2013–2025) on Escherichia coli , Staphylococcus aureus , and related pathogens. Three converging antibacterial targets are identified: ROS generation (72 % …

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Relationship of the neutrophil-to-high-density lipoprotein cholesterol ratio with sarcopenia: A cross-sectional study

Tao Zhang, Ya Zhou, Longfei Luo, Deng-jun Ji et autres

Objective Sarcopenia poses a significant global public health burden, underscoring the urgency of identifying reliable risk markers for early detection and intervention. This study aimed to elucidate the association between the neutrophil-to-high-density lipoprotein cholesterol ratio and sarcopenia as well as explore how …

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Parabacteroides as a promising target for disease intervention: current stage and pending issues

Jing Liu, Hui Qiu, Jiamin Zhao, Nan Shao et autres

Parabacteroides, a promising candidate for the next generation of probiotics, plays a significant role in various diseases. In this review, we provide a comprehensive examination of the biological properties of Parabacteroides, summarize its effects on host health and potential associations with diseases, …

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Lactate dehydrogenase A: a potential new target for tumor drug resistance intervention

Mingyue Wang, Quanling Zhou, Tingping Cao, Fujun Li et autres

Tumor drug resistance is a crucial scientific and technological issue that urgently needs to be addressed in cancer treatment. In recent years, research on Lactate dehydrogenase A (LDHA) in the field of tumor drug resistance has progressively deepened, with breakthrough advancements achieved. …

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MicroRNA-7 as a multifaceted regulator of tumor glycolytic metabolism: Mechanistic insights and therapeutic perspectives

Yiling Zhu, Jiayi Zhang, Xu Zhao, Mengmeng Guo et autres

Aberrant glycolysis is a hallmark of tumor and a key oncogenic driver. However, the complex regulatory networks and dynamic signaling interactions governing glycolysis within the tumor microenvironment (TME) remain incompletely understood, posing significant challenges for developing targeted metabolic therapies. MicroRNA-7 (miR-7), a …

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Dual-specific phosphatases-8: a new target for clinical disease intervention

Tingping Cao, Quanling Zhou, Fujun Li, Mingyue Wang et autres

Dual-specific phosphatase-8 (DUSP8), identified as the first gene in a genome-wide association study (GWAS), is implicated in cellular oxidative stress, proliferation, apoptosis, and drug resistance through its negative regulation of the dephosphorylation activities of JNK, ERK, and p38 within the MAPK pathway. …

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Dominant RDH12-retinitis pigmentosa impairs photoreceptor development and implicates cone involvement in retinal organoids

Cécile Méjécase, Ya Zhou, Nicholas Owen, Pablo Soro-Barrio et autres

Introduction Retinal dehydrogenase 12 (RDH12) is a photoreceptor NADPH-dependent retinal reductase enzyme, converting all-trans-retinal to all-trans-retinol. Heterozygous variants in RDH12 cause a rare autosomal dominant (AD) retinitis pigmentosa. Methods As no disease models exist, we generated human induced pluripotent stem cell-derived retinal …

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34P: Polymeric micelles paclitaxel (pm-Pac), carboplatin combined with sintilimab in the first-line treatment of advanced non-squamous non-small cell lung cancer(nsq-NSCLC): Phase II study

Ya Zhou, Min Shi, Baozhong Shen, Linda Wang et autres

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Mesalazine-Induced Acute Pancreatitis in Inflammatory Bowel Disease Patients: A Systematic Review

Juan Pan, Zu‐Yi Li, Chao Ye, Xiaojuan Zhang et autres

Objective: Mesalazine is a widely used medication for treating mild to moderate inflammatory bowel disease (IBD). First identified as a potential cause of acute pancreatitis (AP) in 1989, the link between mesalazine and AP has primarily been established through case reports and …

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Dominant RDH12 -retinitis pigmentosa impairs photoreceptor development and cone function in retinal organoids

Cécile Méjécase, Ya Zhou, Nicholas Owen, Pablo Soro-Barrio et autres

Abstract Retinal dehydrogenase 12 (RDH12) is a photoreceptor NADPH-dependent retinal reductase enzyme, converting all- trans -retinal to all- trans -retinol. Heterozygous variants in RDH12 cause a rare autosomal dominant (AD) retinitis pigmentosa. As no disease models exist, we generated human induced pluripotent …

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Enhance cancer immunotherapy against melanoma of c-di-GMP loaded by cationic liposome with CMCD as a controlled release agent

Ya Zhou, Bo Huang, Yuanqian Chen, Xue Xiao et autres

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