Jun Fan

Trefoil factor 2 interacts with A4GNT to regulate inflammation to protect against pneumonia during influenza virus infection

Weihui Fu, Jun Fan, Peng Sun, Songhua Yuan et autres

Trefoil factor 2 (TFF2) has been shown to reduce inflammation and promote mucosal repair in models of gastric and colonic injury. However, the role of TFF2 in acute respiratory tract infection remains elusive. Here, we demonstrate that TFF2 protects mice against pneumonia …

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The nucleoside analog 4′-fluorouridine suppresses the replication of multiple enteroviruses by targeting 3D polymerase

Yongkang Chen, Xiaohong Li, Fengyang Han, Beihong Ji et autres

ABSTRACT Human enteroviruses are the major pathogens causing hand-foot-and-mouth disease in infants and young children throughout the world, and infection with enterovirus is also associated with severe complications, such as aseptic meningitis and myocarditis. However, there are no antiviral drugs available to …

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Construction of an infectious clone for enterovirus A89 and mutagenesis analysis of viral infection and cell binding

Jingjing Yan, Min Wang, Xiaohong Li, Jun Fan et autres

ABSTRACT Enterovirus A89 (EV-A89) is an unconventional strain belonging to the Enterovirus A species. Limited research has been conducted on EV-A89, leaving its biological and pathogenic properties unclear. Developing reverse genetic tools for EV-A89 would help to unravel its infection mechanisms and …

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The development and characterization of a stable Coxsackievirus A16 infectious clone with Nanoluc reporter gene

Rui Yu, Min Wang, Lizhen Liu, Jingjing Yan et autres

Coxsackievirus A16 (CA16) belongs to the Human Enterovirus A species, which is a common pathogen causing hand, foot, and mouth disease in children. Currently, specific vaccines and drugs against CA16 are unavailable, and there is an unmet need to further understand the …

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A cysteine protease inhibitor GC376 displays potent antiviral activity against coxsackievirus infection

Yongkang Chen, Xiaohong Li, Min Wang, Yuan Li et autres

Infection with coxsackievirus A10 (CV-A10) can cause hand-foot-mouth disease and is also associated with severe complications, including viral pneumonia, aseptic and viral meningitis. Coxsackievirus infection may also play a role in the pathogenesis of acute myocardial infarction and in the increased risk …

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Nonmuscle myosin IIA promotes the internalization of influenza A virus and regulates viral polymerase activity through interacting with nucleoprotein in human pulmonary cells

Jian Chen, Jian Liu, Zhilu Chen, Daobin Feng et autres

Influenza A virus (IAV), responsible for seasonal epidemics and recurring pandemics, represents a global threat to public health. Given the risk of a potential IAV pandemic, it is increasingly important to better understand virus-host interactions and develop new anti-viral strategies. Here, we …

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Nonmuscle myosin heavy chain IIA facilitates SARS-CoV-2 infection in human pulmonary cells

Jian Chen, Jun Fan, Zhilu Chen, Miaomiao Zhang et autres

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), binds to host receptor angiotensin-converting enzyme 2 (ACE2) through its spike (S) glycoprotein, which mediates membrane fusion and viral entry. However, the expression of ACE2 is extremely …

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Preparation and verification of a monoclonal antibody against a conserved linear epitope in enterovirus A protein 2C

Lizhen Liu, Min Wang, Rui Yu, Wanqing Li et autres

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Human IFN-κ Inhibited Respiratory RNA Virus Replication Dependent on Cell-to-Cell Interaction in the Early Phase

Weihui Fu, Peng Sun, Jun Fan, Longfei Ding et autres

Abstract Background: Interferon kappa (IFN-κ) is a type I interferon (IFN-I) that inhibits virus replication by evoking interferon-stimulated genes (ISGs). However, as an evolutionarily ancient interferon, IFN-κ may function differently from the later emerged interferon-α and β. Methods: Conventional molecular biology methods …

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Correlation Between Early Plasma Interleukin 37 Responses With Low Inflammatory Cytokine Levels and Benign Clinical Outcomes in Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Ang Li, Yun Ling, Zhigang Song, Xiaobo Cheng et autres

BACKGROUND: The immune protective mechanisms during severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection remain to be deciphered for the development of an effective intervention approach. METHODS: We examined early responses of interleukin 37 (IL-37), a powerful anti-inflammatory cytokine, in 254 SARS-CoV-2-infected patients …

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Rules governing genetic exchanges among viral types from different Enterovirus A clusters

Min Wang, Liuyao Zhu, Jun Fan, Jingjing Yan et autres

The species Enterovirus A (EV-A) consists of two conventional clusters and one unconventional cluster. At present, sequence analysis shows no evidence of recombination between conventional and unconventional EV-A types. However, the factors underlying this genetic barrier are unclear. Here, we systematically dissected …

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Inflammatory response in craniopharyngiomas and its clinical significance

Yi Liu, Jun Pan, Jun Fan, Chaohu Wang et autres

Objective To investigate the clinical significance of inflammatory reaction in craniopharyngiomas. Methods Antibody microarray was employed for detection of inflammatory cytokines expression in craniopharyngiomas and other common tumors in sellar region (including the pituitary adenoma, meningioma, pilocytic astrocytoma). The methods of qPCR …

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