Jing Ni

Gigantol induces ferroptosis in gastric cancer via methyltransferase-like 3/YTH domain-containing family protein 2-mediated β-catenin degradation

Chen Wang, Didi Zhao, Haoqi Jiang, Ningning Zhang et autres

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Abstract 5530: Preclinical validation of the antitumor activity and safety of M0324, a novel MUC-1 conditional CD40 agonist, and its combination with immune checkpoint inhibitors (ICIs), for selective immune activation

Weixiao Sha, Jing Ni, Anika Bergmann, Nathalie Duncan et autres

Abstract Background: MUC-1, a glycoprotein commonly overexpressed in various cancers, plays a pivotal role in tumor progression and immune evasion. M0324 is a novel MUC-1-conditional CD40 agonist designed to activate antigen-presenting cells in the presence of MUC-1-overexpressing tumor cells. Targeted CD40 activation …

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Berberine triggers apoptosis through the PI3K/Akt pathways and Nrf2 by inducing ROS in papillary thyroid cancer

Jing Li, Ziyi Zhu, Jing Ni, Lizi Ye et autres

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Abstract ND12: M0324, a novel MUC-1 conditional CD40 agonist for selective immune activation in MUC-1 overexpressing tumors

Weixiao Sha, Yilang Tang, Jing Ni, Anika Bergmann et autres

Abstract Background: Anti-CD40 agonistic antibodies have been explored in clinical trials over the last few decades; however, to date none have been approved. Systemic activation of CD40 by anti-CD40 antibodies can lead to adverse effects such as liver toxicity, infusion-related reactions, thrombocytopenia, …

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Adipose-derived mesenchymal stem cells (ADMSCs) protect against hyperglycemia and hyperlipidemia-induced heart failure by inhibiting autophagy-related apoptosis

Xu Xu, Lingyun Tao, Jie Zhou, Jing Ni

Abstract Background Mesenchymal stem cells (MSCs), a type of seed cell, are expected to improve impaired diabetic cardiac function. Inflammation and autophagy play an important role in the development of metabolic disorder-induced heart failure. The aim of this work was to assess …

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Adipose Tissue Derived Mesenchymal Stem Cells (ADMSCs) Protect Against Hyperglycemia and Hyperlipidemia Induced Heart Failure by Inhibiting Autophagy Related Apoptosis

Xu Xu, Sujing Qiang, Lingyun Tao, Jie Zhou et autres

Abstract Background Mesenchymal stem cells (MSCs), kinds of seed cells, are expected to improve impaired diabetic cardiac function. Inflammation and autophagy play the important role in the development of metabolic disorder induced heart failure. The aim of this work was to assess …

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Stimulation of astrocytic sigma-1 receptor is sufficient to ameliorate inflammation- induced depression

Lin Guo, Tianyu Gao, Ce Gao, Xiaoxia Jia et autres

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Abstract 13285: Short-term Low-saturated Fat Diet Compared to High-saturated Fat Diet Improves Monocyte Phenotypes in Subjects With Hypertriglyceridemia

Zeqin Lian, Xiaoyuan Dai Perrard, Antu Antony, Xu Lu et autres

Introduction: Clinical trials suggest that low-saturated fat diet (LSFD) may reduce the risk of atherosclerotic cardiovascular disease (ASCVD) in subjects with hypertriglyceridemia (HTG). Monocytes play crucial roles in atherogenesis. Hypothesis: LSFD vs high-saturated fat diet (HSFD) improves monocyte phenotypes, thereby reducing ASCVD …

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Salidroside protects against cardiomyocyte apoptosis and ventricular remodeling by AKT/HO-1 signaling pathways in a diabetic cardiomyopathy mouse model

Jing Ni, Yuanmin Li, Yawei Xu, Rong Guo

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Mitochondrial transplantation attenuates lipopolysaccharide- induced depression-like behaviors

Yun Wang, Jing Ni, Ce Gao, Liming Xie et autres

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Exosomes Derived from TIMP2-Modified Human Umbilical Cord Mesenchymal Stem Cells Enhance the Repair Effect in Rat Model with Myocardial Infarction Possibly by the Akt/Sfrp2 Pathway

Jing Ni, Xijun Liu, Yiheng Yin, Peiyu Zhang et autres

Exosomes derived from human umbilical cord mesenchymal stem cells (hucMSCs) are a promising new therapeutic option for myocardial infarction (MI). The tissue matrix metalloproteinase inhibitor 2, also known as TIMP2, is a member of the tissue inhibitor family of metalloproteinases. Since TIMP2-mediated …

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Inhibition of activated astrocyte ameliorates lipopolysaccharide- induced depressive-like behaviors

Yun Wang, Jing Ni, Lingyan Zhai, Ce Gao et autres

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