Jiaxin Wu

ROS‐Responsive Eye Drop for Controlled Release of 20‐Deoxyingenol Improves Diabetic Corneal Healing by Activating Macrophage Autophagy and Metabolic Reprogramming

Jiaxin Wu, Wanying Chen, Haijiang Qiu, Weihan Zheng et autres

Impaired corneal wound healing in diabetes remains a major clinical challenge, driven by defective autophagy, metabolic dysregulation, and sustained inflammation within a high-reactive oxygen species (ROS) microenvironment. Here, we engineered a ROS-responsive ocular delivery system based on N1-(4-boronobenzyl)-N3-(4-boronophenyl)-N1, N1, N3, N3-tetramethylpropane-1,3-diaminium (TSPBA)/poly(vinyl …

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CSF1R signaling contributes to macrophage-associated CCL11 production and eosinophil recruitment in murine allergic conjunctivitis

Jingheng Du, Jiaxin Wu, Xiukui Tan, Jingbin Xie et autres

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Hypoxia Alters Corneal Circadian Rhythms and Disrupts Epithelial, Neural, and Immune Balance

Jiangman Liu, Jiaxin Wu, Dingli Lu, Zhijie Li

Purpose: The cornea operates under robust circadian control and is essential for ocular-surface homeostasis. Hypoxic stress-prevalent in many eye disorders and systemic conditions-can disturb these rhythms and compromise epithelial, neural, and immune balance. Here, we examine how environmental hypoxia (EH) and chemical …

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NF-κB/IL-6 axis drives impaired corneal wound healing in aqueous-deficient dry eye

Cuipei Lin, Jiaxin Wu, Yuxin Jing, Jingyi Xie et autres

Dry eye disease (DED) commonly leads to compromised corneal epithelial integrity and chronic ocular surface inflammation; however, the precise molecular mechanisms underlying impaired corneal healing remain incompletely understood. In this study, we established an aqueous-deficient DED mouse model via extraorbital lacrimal gland …

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Corneal Sensory Nerve Injury Disrupts Lacrimal Gland Function by Altering Circadian Rhythms in Mice

Senmao Li, Jingyi Xie, Ruyu Yan, Jiangman Liu et autres

Purpose: To investigate the impact of corneal sensory nerve injury on lacrimal gland function, focusing on mechanisms involving the superior salivatory nucleus (SSN), circadian rhythm disruption, immune microenvironment alterations, and the potential for neural regeneration. Methods: A murine model of corneal sensory …

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Restorative Effects of Short-Chain Fatty Acids on Corneal Homeostasis Disrupted by Antibiotic-Induced Gut Dysbiosis

Sijing Liu, Jiangman Liu, Ruyu Yan, Senmao Li et autres

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Activation of the SST-SSTR5 signaling pathway enhances corneal wound healing in diabetic mice

Xinwei Chen, Yan Li, Liyuan Lu, Jiaxin Wu et autres

Corneal wound healing in diabetic patients is usually delayed and accompanied by excessive inflammation. However, the underlying cellular and molecular mechanisms remain poorly understood. Here, we found that somatostatin (SST), an immunosuppressive peptide produced by corneal nerve fibers, was significantly reduced in …

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