Suhe Dong

Mannose Ameliorates Radiation-Induced Intestinal Injury in Mice via Preventing Mitochondrial Dysfunction

Yanqing Liu, Renjun Peng, Yiying Zhang, Jing Dai et autres

Aims: Radiation-induced intestinal injury (RIII) severely compromises the quality of life in patients undergoing abdominal/pelvic radiotherapy and may necessitate treatment discontinuation. To date, there is no approved agent for the prevention or treatment of RIII. This study aims to clarify the protective …

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Phosphorylated PTEN participates in chromatin remodeling during the DNA damage response

zhongmin Chen, Wei Li, Xinmin DING, Fengsheng LI et autres

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DMSO Protects Against Radiation-Induced Ovarian Injury by Preserving Mitochondrial Function and Alleviating DNA Damage

Jie Zhou, Renjun Peng, Zhongmin Chen, Yiying Zhang et autres

Background and Purpose Radiation-induced ovarian injury (RIOI) compromises the clinical utility of pelvic radiotherapy and reduces fertility in young female patients. Dimethyl sulfoxide (DMSO) exhibits antioxidant property. Hearin, we aimed to explore the protective effect and underlying mechanism of DMSO on RIOI. …

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ACE2 Activation in Intestinal Epithelial Cells Prevents Radiation-Induced Intestinal Injury

Xin Song, Renjun Peng, Zhongmin Chen, Jing Dai et autres

Aims: Radiation-induced intestinal injury (RIII) significantly impairs the quality of life in patients with abdominal/pelvic cancer undergoing radiotherapy, often necessitating treatment cessation. The ACE2/Ang-(1–7)/MasR axis, a protective pathway within the renin-angiotensin system, represents a potential anti-inflammatory target. This study explored the role …

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N-CWS promotes the repair of radiation-induced skin injury by enhancing angiogenesis

Sinian Wang, Manze Zhang, Xuewei Guo, Zhongmin Chen et autres

PURPOSE: Radiation-induced skin injury is a common complication that seriously affects the follow-up treatment and life quality of tumor patients. Nocardia rubra cell-wall skeleton (N-CWS) has been reported to have pro-angiogenesis effects, and its role on RISI remains unclear. The aim of …

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Piezo1 regulates autophagy in HT22 hippocampal neurons through the Ca2+/Calpain and Calcineurin/TFEB signaling pathways

Yan Lü, Hao Zhang, Suhe Dong, Z. Zhang et autres

OBJECTIVE: To investigate the functional and molecular mechanisms by which Piezo1regulates HT-22 hippocampal neuronal autophagy, and to explore whether Piezo1 regulates hippocampal neuronal autophagy via the Ca2+/Calpain, CaMKKβ, or Calcineurin pathways. METHODS: The impacts of Piezo1 inhibition, activation and gene knockdown on …

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Bongkrekic Acid and Its Novel Isomers: Separation, Identification, and Determination in Food Matrices

Suhe Dong, D. Liu, Runfeng Lin, Ying‐Jie Zhu et autres

The toxicity associated with bongkrekic acid (BKA) is severe due to its chemical structure, which also facilitates high mortality rates; however, its isomer, isobongkrekic acid (iBKA), with only minor structural variance, demonstrates marked differences in toxicity. This discrepancy in structural properties and …

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Rapid UHPLC-MS/MS Detection of Prohibited Drugs in Cosmetics Using Pass-Through SPE

Jie Mao, Jing Peng, Ying‐Jie Zhu, Xin Jiang et autres

Prolonged exposure to drugs prohibited in cosmetics may cause irritation and allergic reactions in humans. In this study, a method using ultrahigh performance liquid chromatography-tandem mass spectrometry was established for the simultaneous determination of 64 prohibited drugs spanning 11 categories, including 39 …

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Quantitative Analysis of Pyrrolizidine Alkaloids in Food Matrices and Plant-Derived Samples Using UHPLC—MS/MS

Runfeng Lin, Jing Peng, Ying‐Jie Zhu, Suhe Dong et autres

Pyrrolizidine alkaloids (PAs) are a class of nitrogen-containing basic organic compounds that are frequently detected in foods and herbal medicines. Owing to their potential hepatotoxic, genotoxic, and carcinogenic properties, PAs have become a significant focus for monitoring global food safety. In this …

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N-formylmethionine-leucyl-phenylalanine protects against irradiation-induced damage to hematopoiesis and intestines

Zhihua Li, Yatong Wu, Sinian Wang, Fengsheng Li et autres

BACKGROUND: Ionizing radiation (IR), including radiotherapy, can exert lasting harm on living organisms. While liposaccharide (LPS) offers resistance to radiation damage, it also induces toxic responses. Thankfully, an LPS analogue called N-formylmethionine-leucyl-phenylalanine (fMLP) holds the potential to mitigate this toxicity, offering hope …

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Combination of biotransformation and metabolomics reveals tolfenpyrad-induced hepatocytotoxicity

Xin Jiang, Yingjie Zhu, Suhe Dong, Runfeng Lin et autres

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Highly sensitive and accurate measurement of underivatized phosphoenolpyruvate in plasma and serum via EDTA-facilitated hydrophilic interaction liquid chromatography–tandem mass spectrometry

Danning Shen, Ying‐Jie Zhu, Jie Mao, Runfeng Lin et autres

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