Zhuolin Zhou

Patient-derived decidual organoids reveal rhG-CSF-associated protective responses involving JAK2/STAT3 signaling in recurrent spontaneous abortion

Changqiang Wei, Xuemei Tan, Y J Wei, 程金莲 et autres

BACKGROUND: Recurrent spontaneous abortion (RSA) is a complex reproductive disorder frequently lacks effective therapeutic interventions. Recombinant human granulocyte colony-stimulating factor (rhG-CSF) has shown promise in improving pregnancy outcomes in RSA, but its underlying mechanisms remain unclear. Organoid technology offers new opportunities for …

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Disrupting KAT8 Liquid–Liquid Phase Separation with Hybrid Vesicle–Liposome Platform for Enhanced PD‐L1 Blockade Treatment

Xinrong Hu, Hua Zhu, Qian‐Fang Meng, Xiaoqin He et autres

Programmed cell death protein 1/its ligand 1 (PD-1/PD-L1) blockade has revolutionized cancer immunotherapy, yet its efficacy is limited by incomplete checkpoint inhibition and persistent PD-L1 transcription. In this work, lysine acetyltransferase 8 (KAT8) is identified as a nucleator of liquid-liquid phase separation …

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Extracellular matrix stiffness in hepatocellular carcinoma: mechanisms and targeted therapeutic strategies

Zhuolin Zhou, Ximing Xu

Given the abundant stroma of the liver and that cirrhosis or hepatic fibrosis is the premalignant condition of most hepatocellular carcinomas (HCC), underscores the critical interaction between extracellular matrix (ECM) stiffness and the tumor microenvironment (TME) in the initiation, progression, and immunotherapy …

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Research on a Predictive Model for Microalbuminuria in Type 2 Diabetes Based on Machine Learning and SHAP Analysis

Zixuan Liu, Zhuolin Zhou, Yu Sun, Xiaotian Du et autres

Background: Type 2 diabetes mellitus (T2DM) is associated with kidney damage, with microalbuminuria (MAU) serving as an early marker indicating the risk of progression to severe renal and cardiovascular complications, and there is an urgent need for effective prediction tools to identify …

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Matrix stiffening-driven hepatocellular carcinoma progression through OASL-mediated cGAS-STING repression and subsequent macrophage activation

Zhuolin Zhou, Jiayu Chen, Ning Lü, Jingyu Wu et autres

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Identification and validation of cell senescence genes in recurrent spontaneous abortion via multiple bioinformatics algorithms

Yiyun Wei, Zhuolin Zhou, Changqiang Wei, Shanshan Lin et autres

Recurrent spontaneous abortion (RSA) represents a significant challenge in reproductive obstetrics, affecting approximately 5% of couples globally. Despite various treatments, the effectiveness of these interventions remains highly contentious. Emerging evidence suggests that cellular senescence plays a critical role in the pathogenesis of …

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An interpretable machine learning model for predicting metabolic dysfunction‐associated steatotic liver disease in patients with type 2 diabetes

Zhuolin Zhou, Nan Gao, Xiaomin Ma, Zhijuan Ge et autres

AIM: Patients with type 2 diabetes mellitus (T2DM) exhibit an elevated prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) and are at greater risk of liver-related adverse events. Existing non-invasive tools show limited diagnostic performance in this population. This study aims to …

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Author response for "An interpretable machine learning model for predicting metabolic dysfunction‐associated steatotic liver disease in patients with type 2 diabetes"

Zhuolin Zhou, Nan Gao, Jiaojiao Liu, Xiaomin Ma et autres

Nanodelivery of Y-27632 by RGD-modified liposome enhances radioimmunotherapy of hepatocellular carcinoma via tumor microenvironment matrix stiffness reprogramming

Yang Shen, Zihui Zheng, Xinyao Hu, Zhuolin Zhou et autres

RGD@LP-Y enhances RT sensitivity by remodeling ECM stiffness, modulating the hypoxia and immunosuppressive conditions within TME, and enhancing the ICD. The study provides a safe combinatorial approach for HCC therapy.

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m6A-modified circCCAR1 promotes malignant proliferation by enhancing KIF5B expression in hepatocellular carcinoma

Jiayu Chen, Zhuolin Zhou, Yang Shen, Xinyao Hu et autres

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A review of immune checkpoint inhibitor-associated myocarditis: Epidemiology, pathogenesis, and biomarkers

Le Xu, Yukai Chen, Lin Xiong, Yang Shen et autres

Immune checkpoint inhibitor (ICI) have demonstrated efficacy in treating various cancers by modulating the immune system, but this can lead to immune-related adverse events (irAEs), including myocarditis. ICI-associated myocarditis is a rare but highly lethal irAE with a short mean time to …

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Study on medication adherence in patients with gestational diabetes mellitus complicated by postpartum glucose metabolism disorders based on the risk perception attitude framework

Bing Zhou, Zhuolin Zhou, Yu Sun, Ting He et autres

Objective: This study aims to assess the compliance with anti-hypoglycemic drugs among postpartum patients with gestational diabetes mellitus (GDM) through a questionnaire survey, and to examine the factors that may influence this adherence. The goal is to enhance pharmacists' medication practices and …

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