Yuyi Wu

Enhancing retinal cells anti-attenuation under oxidative stress by NMN-loaded gelatin nanoparticles via efficiently intracellular delivery

Tien-Chun Yang, Pei-Hsin Chu, Huai‐An Chen, Yuyi Wu et autres

Oxidative stress plays a critical role in retinal degeneration, contributing to cellular apoptosis and senescence in retinal pigment epithelial (RPE) cells and retinal ganglion cells (RGCs). Nicotinamide mononucleotide (NMN), a key precursor of NAD + , has shown potential in protecting against …

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Association between mitochondrial DNA copy number and the risk of Parkinson’s disease: a meta-analysis and Mendelian randomization study

Duo Zhang, Yong Gan, Yuyi Wu, Wei Xiang

BACKGROUND: Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by both motor and non-motor symptoms, with mitochondrial dysfunction being a key pathological feature. Alterations in mitochondrial DNA copy number (mtDNA-CN) have been implicated in PD, but the relationship remains controversial. This …

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Interaction and Start-Up Dynamics Analysis of Metallic Dust in GIS Under DC Voltage

Danmeng Wang, Teng Zhang, Ying Feng, Yuyi Wu et autres

Gas-insulated switchgear (GIS) inevitably contains metal dust. The start-up and migration of metallic dust under an electric field are critical factors in initiating insulation failure. This paper develops a dust start-up dynamic model considering interaction forces, analyzes the dynamic mechanisms of dust …

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LGMMFusion: A LiDAR-guided multi-modal fusion framework for enhanced 3D object detection

Haixing Cheng, C. Liu, Wenzhe Gu, Yuyi Wu et autres

Multi-modal data fusion plays a critical role in enhancing the accuracy and robustness of perception systems for autonomous driving, especially for the detection of small objects. However, small object detection remains particularly challenging due to sparse LiDAR points and low-resolution image features, …

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The immunosuppressive microenvironment modulated by glioma-associated mesenchymal stem cells: Current status and potential strategies

Yuyi Wu, Wei Xiang, Peng Fu

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Study on energy evolution and crack propagation of filling mortar-rock at different loading rates

Chengyong Liu, Yuyi Wu, Tongde Zhao

Shotcrete, as a highly efficient reinforcement material widely used in geotechnical engineering, demonstrates irreplaceable advantages in projects such as tunnel excavation, mine roadway support, and slope protection. However, when shotcrete becomes tightly bonded with rock masses, the energy evolution and crack initiation …

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Deep brain stimulation for dystonia treatment in cerebral palsy: efficacy exploration

Haoyang Zheng, Duo Zhang, Xiang Wei, Yong Gan et autres

Dystonia, a challenging movement disorder, poses significant therapeutic challenges due to its resistance to treatment, resulting in both physical impairment and substantial mental distress, ultimately impacting overall quality of life. Cerebral palsy (CP) is a major non-genetic cause of secondary dystonia, characterized …

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Modelling of flaky particle motion under typical vibration excitation for gas insulated switchgear live operation

Jian Wang, Chengyi Qin, Teng Zhang, Keda Chen et autres

Abstract Within 30 min after live operation of gas‐insulated switchgear (GIS), more than 60% of discharge failures are caused by metallic particles. To address this issue, this study explored the vibration propagation mechanisms in GIS cavities and established an equivalent vibration transmission …

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Fusion of glioma-associated mesenchymal stem/stromal cells with glioma cells promotes macrophage recruitment and M2 polarization via m6A modification of CSF1

Zhen Liu, Sujie Gu, Zesheng Peng, Yihao Wang et autres

Abstract Malignant glioma is the most common primary malignant tumor of the brain in adults, with glioblastoma (GBM) being the most aggressive subtype. Mesenchymal stem/stromal cells (MSCs) have been shown to fuse with tumor cells in various cancers including glioma, thereby regulating …

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Platelet-derived extracellular vesicle drug delivery system loaded with kaempferol for treating corneal neovascularization

Guei‐Sheung Liu, Huai‐An Chen, Che-Yi Chang, Yin‐Ju Chen et autres

Platelet-derived extracellular vesicles (PEVs) have drawn attention due to their multifunctionality, ease of procurement, and abundant supply from clinical-grade platelet concentrates. PEVs can be readily endocytosed due to their lipid bilayer membrane and nanoscale structure, enhancing the bioavailability and efficacy of their …

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CFD Numerical Simulation of Slurry Flow Characteristics Under the Clogged Form of Coal Gangue Slurry Transportation Pipeline

Lei Zhu, Zhi Li, Yuyi Wu, Chengyong Liu et autres

Slurry filling technology has been increasingly adopted in coal mines in the northwest region. However, due to the complexity of slurry transport pipelines, blockages remain a frequent issue. These blockages can reduce operational efficiency, with different blockage types causing varying levels of …

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Identification of therapeutic targets and immune landscape in glioblastoma through crosstalk with glioma-associated mesenchymal stem cells

Haoyang Zheng, Haofei Wang, Duo Zhang, Yong Gan et autres

BACKGROUND: Glioma-associated mesenchymal stem cells (GA-MSCs) are one of the key factors limiting the effectiveness of glioblastoma (GBM) treatment and contributing to poor patient prognosis, making them a potential therapeutic target for GBM. In-depth research into the complex crosstalk between GA-MSCs and …

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