Yongkui Yu

Development of a predictive model for pathological complete response following neoadjuvant immunotherapy and chemotherapy in locally advanced resectable esophageal squamous cell carcinoma

Yilei Zhang, Hounai Xie, Deguo Zhang, Yujuan Liu et autres

BACKGROUND: Neoadjuvant immunotherapy and chemotherapy (nICT) has demonstrated substantial therapeutic efficacy in patients with locally advanced esophageal squamous cell carcinoma (LA-ESCC). This study aimed to develop a model to predict the pathological complete response (pCR) following neoadjuvant therapy for esophageal squamous cell …

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Quantitative Membrane Paramagnetic Relaxation Enhancement (mPRE) Measurements on Lipid-Anchored Proteins: Insight into Orientational Dynamics

Junyong Wu, Yongkui Yu, L. Wang, Leiyi Ji et autres

The function of many lipid-anchored eukaryotic proteins critically depends on their specific orientations relative to the membranes, which can block key active centers or binding interfaces. A precise mapping of these orientational landscapes is therefore vital for elucidating/understanding protein function, yet it …

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Prognostic impact of different lymph node staging systems in patients with esophageal squamous cell carcinoma

Peinan Chen, Tongtong Ren, Ning Wu, Qi Liu et autres

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Knowledge, attitudes, and practices of esophageal cancer patients regarding pulmonary rehabilitation training

Wei Wang, Wenqun Xing, Peinan Chen, Haibo Sun et autres

Introduction This study aimed to assess the knowledge, attitudes, and practices (KAP) of esophageal cancer patients concerning pulmonary rehabilitation training. Methods A cross-sectional study was conducted at the Henan Cancer Hospital from July 1, 2024, to August 31, 2024. Data were collected …

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Distinct survival, optimal combination strategy of immunotherapy, and immunophenotype in uncommon and 20ins EGFR-mut lung adenocarcinoma: a multi-center study

Yiting Sun, Lei Xu, Chaoqiang Deng, Xinyang Du et autres

The efficiency and optimal combination strategies of immune checkpoint inhibitors (ICI) in lung adenocarcinoma (LUAD) patients with epidermal growth factor receptor (EGFR) other mutations apart from 19del/L858R (classical), which account for up to 20% EGFR mutations, remains unclear. In this retrospective multi-center …

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Hsa_circ_0018909 promotes non-small cell lung cancer by directly regulating hsa-miR-513b-5p

Qi Liu, Yongkui Yu, Haomiao Li, Wei Wang et autres

Background: Circular RNAs (circRNAs) regulate gene expression by functioning as competing endogenous RNAs (ceRNAs) and are increasingly recognized for their involvement in cancer progression. Hsa_circ_0018909 is upregulated in non-small cell lung cancer (NSCLC); however, its functional role and underlying mechanisms remain poorly …

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Development and validation of the systemic nutrition/inflammation index for improving perioperative management of non-small cell lung cancer

Peiyu Wang, Shaodong Wang, Qi Huang, Xiankai Chen et autres

BACKGROUND: Systemic nutrition and inflammation status is recognized for its influence on cancer survival, yet its role in perioperative outcomes remains poorly defined. This study aimed to refine the assessment of systemic nutrition and inflammation status in non-small cell lung cancer (NSCLC) …

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The Application of iPSCs in Tumour Immunotherapy

Peinan Chen, Jian Hua Gao, Jianing Feng, Yongkui Yu et autres

BACKGROUND: Tumour immunotherapy holds great promise as a treatment for cancer, which ranks as the second highest cause of mortality worldwide. This therapeutic approach can be broadly categorized into two main types: active immunotherapy and passive or adoptive immunotherapy. Active immunotherapy, such …

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Why Pre-Second-Surgery Pulmonary Function Alone is Insufficient: The Development and External Validation of Machine-Learning Models Based on Single- Versus Dual-Time-Point Perioperative Data to Predict Intractable Hypoxemia During One-Lung Ventilation in Repeat Pulmonary Resection

Huixian Li, Xu Liu, Wei Tang, Xiaodong Yang et autres

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Multimodality Therapy and Survival Outcomes in Resectable Primary Small Cell Carcinoma of the Esophagus: A Multicenter Retrospective Study

Lei Xu, Yu‐Shang Yang, Bin Li, Siyun Lin et autres

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Perioperative toripalimab plus neoadjuvant chemotherapy might improve outcomes in resectable esophageal cancer: an interim analysis of a phase III randomized clinical trial

Yan Zheng, Guanghui Liang, Dongfeng Yuan, Xianben Liu et autres

BACKGROUND: In the era of immunotherapy, neoadjuvant immunochemotherapy (NAIC) for the treatment of locally advanced esophageal squamous cell carcinoma (ESCC) is used clinically but lacks of high-level clinical evidence. This study aimed to compare the safety and long-term efficacy of NAIC followed …

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Neoadjuvant chemotherapy combined with immunotherapy versus neoadjuvant chemoradiotherapy in patients with locally advanced esophageal squamous cell carcinoma

Yongkui Yu, Fanyu Meng, Xiufeng Wei, Xiankai Chen et autres

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