Qihui Wu

Ca2+-Independent Exocytosis Favors Axonal Release through Enlarged Fusion Pores in Sensory Neurons

Rong Huang, Xingyu Du, Qihui Wu, Yuan Wang et autres

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Integrative epigenomic and transcriptomic profiling reveals organ-specific and coordinated cold stress responses in the brain and gill of Nile tilapia

X. L. Li, Siyao Zhan, Fan Xu, W. Li et autres

Cold stress is a major environmental challenge limiting the survival and productivity of tropical aquaculture species such as Nile tilapia (Oreochromis niloticus). The brain and gill represent two key organs that orchestrate systemic and environmental responses: the brain serves as the central …

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Aggregation and Propagation of α‐Synuclein in Parkinson's Disease: A Bibliometric Perspective

Xinyue Zhang, Yizhao Ma, Ge Gao, Qihui Wu

INTRODUCTION: Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the aggregation and propagation of alpha-synuclein (α-syn), processes that contribute to neuronal dysfunction and cell death. Although substantial progress has been made in understanding α-syn pathology, a comprehensive bibliometric evaluation of …

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Deficiency of SSTR2a promotes body growth by activating the GH/IGF axis in Nile tilapia Oreochromis niloticus

Lina Sun, Qihui Wu, Ran Cai, Shuangyi Yang et autres

Somatostatin (SST), named for its ability to inhibit pituitary growth hormone (GH) secretion, is involved in multiple physiological processes though somatostatin receptors (SSTRs). Both in vitro and in vivo studies have demonstrated that SSTR2 mediates GH inhibition by SST. However, whether a …

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Action Potential Firing Patterns Regulate Dopamine Release via Voltage‐Sensitive Dopamine D2 Autoreceptors in Mouse Striatum In Vivo

Xiaoxuan Sun, Lili Yin, Zhongjun Qiao, Muhammad Younus et autres

Abstract Dopamine (DA) in the striatum is vital for motor and cognitive behaviors. Midbrain dopaminergic neurons generate both tonic and phasic action potential (AP) firing patterns in behavior mice. Besides AP numbers, whether and how different AP firing patterns per se modulate …

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Genetically modified E. Coli secreting melanin (E.melanin) activates the astrocytic PSAP-GPR37L1 pathway and mitigates the pathogenesis of Parkinson’s disease

Weixian Kong, Yu Liu, Pu Ai, Yong Bi et autres

The characteristic neuropathology of Parkinson's disease (PD) involves the abnormal accumulation of phosphorylated α-synuclein (αSyn), as well as a significant decrease in neuromelanin (NM) levels within dopamine neurons (DaNs). Unlike αSyn aggregates, the relationship between NM levels and PD pathogenesis is not …

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DNA methylation plays a critical role in testicular maintenance, but not in sex determination of male tilapia Oreochromis niloticus

Feilong Wang, Tian Gao, Xiaolong Yang, Qihui Wu et autres

The significance of DNA methylation in fish sex determination and differentiation is increasingly being recognized. Exploring the role of DNA methylation in sex determination and differentiation is advantageous for the advancement of sex control techniques in aquaculture. In this study, the global …

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Corrigendum: Systems pharmacology approach to investigate the mechanism of Kai-Xin-San in Alzheimer’s disease

Yunxia Luo, Dongli Li, Yanfang Liao, Chuipu Cai et autres

[This corrects the article DOI: 10.3389/fphar.2020.00381.].

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Modulating endoplasmic reticulum stress in APP/PS1 mice by Gomisin B and Osthole in Bushen-Yizhi formula: Synergistic effects and therapeutic implications for Alzheimer's disease

Jinman Liu, Qihui Wu, Qiqing Wu, Guangcheng Zhong et autres

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Systems pharmacology dissection of pharmacological mechanisms of Xiaochaihu decoction against human coronavirus

Lvjie Xu, Chuipu Cai, Jiansong Fang, Qihui Wu et autres

BACKGROUND: Although coronavirus disease 2019 (COVID-19) pandemic is still rage worldwide, there are still very limited treatments for human coronaviruses (HCoVs) infections. Xiaochahu decoction (XCHD), which is one of the traditional Chinese medicine (TCM) prescriptions in Qingfeipaidu decoction (QFPDD), is widely used …

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Deciphering comprehensive features of tumor microenvironment controlled by chromatin regulators to predict prognosis and guide therapies in uterine corpus endometrial carcinoma

Qihui Wu, Ruotong Tian, Jiaxin Liu, Chunlin Ou et autres

Background: Dysregulation of chromatin regulators (CRs) can perturb the tumor immune microenvironment, but the underlying mechanism remains unclear. We focused on uterine corpus endometrial carcinoma (UCEC) and used gene expression data from TCGA-UCEC to investigate this mechanism. Methods: We used weighted gene …

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Regulating quantal size of neurotransmitter release through a GPCR voltage sensor

Quanfeng Zhang, Bing Liu, Yinglin Li, Lili Yin et autres

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