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Profil bibliographique

Ahmet Yıldız

Informations fournies par OpenAlex. Research Africa ne déduit ni nationalité, ni poste, ni coordonnées personnelles.

212Publications signalées
10959Citations signalées
2Affiliations récentes

Les institutions déclarées

Les domaines associés

Microtubule and mitosis dynamicsMicro and Nano RoboticsProtist diversity and phylogenyCellular transport and secretionGenetic and Kidney Cyst Diseases

Les publications récentes

Accès ouvert 2025 preprint OpenAlex

Structural Basis of Human Kinetochore-Microtubule Coupling by the Ndc80 and Ska Complexes

Ju Zhou, Yuanchang Zhao, Ahmet Yıldız, Eva Nogales

The outer kinetochore (KT) physically links chromosomes to dynamic microtubule (MT) plus ends, coupling to both polymerizing and depolymerizing tips to support chromosome movements while maintaining robust attachment. In human cells, the Ska complex is thought to function analogously to the yeast …

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2 citations bioRxiv (Cold Spring Harbor Laboratory)
Accès ouvert 2025 preprint OpenAlex

Structure and mechanism of microtubule stabilization and motor regulation by MAP9

Burak Çetin, Aryan Taheri, Mert Gölcük, Brigette Y. Monroy et autres

Microtubule-associated proteins (MAPs) regulate the organization of microtubules and control intracellular transport, but their individual contributions to microtubule dynamics and motor regulation remain poorly understood. Here, we identify MAP9 as a critical factor that stabilizes microtubules and facilitates neuronal morphogenesis. MAP9 knockdown …

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5 citations bioRxiv (Cold Spring Harbor Laboratory)
Accès ouvert 2025 preprint OpenAlex

Enhanced Processivity and Collective Force Production of Kinesin-1 at Low Radial Forces

Andrew Hensley, Ahmet Yıldız

Kinesin-1 is a robust motor that carries intracellular cargos towards the plus ends of microtubules. However, optical trapping studies reported that kinesin-1 is a slippery motor that quickly detaches from the microtubule, and multiple kinesins are incapable of teaming up to generate …

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1 citation bioRxiv (Cold Spring Harbor Laboratory)
Accès ouvert 2025 article OpenAlex

NuMA mechanically reinforces the spindle independently of its partner dynein

Nathan H. Cho, Merve Aslan, Aryan Taheri, Ahmet Yıldız et autres

During cell division, both motor and non-motor proteins organize microtubules to build the spindle and maintain it against opposing forces. Nuclear mitotic apparatus (NuMA), a long microtubule-binding protein, is essential to spindle structure and function. NuMA recruits the motor dynein to actively …

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7 citations Current Biology
Accès ouvert 2025 preprint OpenAlex

From Attraction to Repulsion: Omicron-Driven Rewiring of Nanobody Interfaces on the SARS-CoV-2 RBD

Mert Gölcük, Fareeda E. Abu-Juam, Derman Basturk, Clara Xazal Buran et autres

ABSTRACT Mutations in the SARS-CoV-2 spike receptor-binding domain (RBD) of the Omicron variant enable broad escape from neutralizing antibodies (Abs) and nanobodies (Nbs), yet the atomistic basis of epitope-dependent loss of Nb binding remains unclear. We performed all-atom molecular dynamics (MD) simulations …

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0 citations bioRxiv (Cold Spring Harbor Laboratory)
Accès ouvert 2025 article OpenAlex

Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex

Minghao Chen, Thanh Ngoc Nguyen, Xuefeng Ren, Grace Khuu et autres

The Unc-51-like kinase protein kinase complex (ULK1C) is the most upstream and central player in the initiation of macroautophagy in mammals. Here, we determined the cryo-electron microscopy structure of the human ULK1C core at amino-acid-level resolution. We also determined a moderate-resolution structure …

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23 citations Nature Structural & Molecular Biology

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